PGC-1α at the crossroads of type 2 diabetes

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.

[1]  M. Carlson,et al.  The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? , 1998, Annual review of biochemistry.

[2]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[3]  J. Holloszy.  Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. , 1967, The Journal of biological chemistry.

[4]  Douglas L. Rothman,et al.  Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance , 2003, Science.

[5]  R. Bassel-Duby,et al.  Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK , 2002, Science.

[6]  L. Goodyear,et al.  Invited review: intracellular signaling in contracting skeletal muscle. , 2002, Journal of applied physiology.

[7]  L. Guarente,et al.  How does calorie restriction work? , 2003, Genes & development.

[8]  Jing He,et al.  Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. , 2002, Diabetes.

[9]  Zhaohui Feng,et al.  Identification of a biochemical link between energy intake and energy expenditure. , 2002, The Journal of clinical investigation.

[10]  D. Hood.  Plasticity in Skeletal, Cardiac, and Smooth Muscle Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle , 2001 .

[11]  P. Puigserver,et al.  Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.

[12]  R. Eckel,et al.  Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. , 1998, Journal of applied physiology.

[13]  J. Neel.  Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? , 1962, American journal of human genetics.