Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis

The indistinctive effects of antiangiogenesis agents in gastric cancer (GC) can be attributed to multifaceted gene dysregulation associated with angiogenesis. Angiopoietin‐like (ANGPTL) proteins are secreted proteins regulating angiogenesis. They are also involved in inflammation and metabolism. Emerging evidences have revealed their various roles in carcinogenesis and metastasis development. However, the mRNA expression profiles, prognostic values, and biological functions of ANGPTL proteins in GC are still elucidated.

[1]  G. Tortora,et al.  Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer , 2018, International journal of molecular sciences.

[2]  Jing Wang,et al.  LinkedOmics: analyzing multi-omics data within and across 32 cancer types , 2017, Nucleic Acids Res..

[3]  Yinghui Zhu,et al.  ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. , 2017, Cancer research.

[4]  Pengcheng Zhu,et al.  ANGPTL4 T266M variant is associated with reduced cancer invasiveness. , 2017, Biochimica et biophysica acta. Molecular cell research.

[5]  H. Kitagawa,et al.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines , 2017, Scientific Reports.

[6]  D. Melisi,et al.  EMT and Treatment Resistance in Pancreatic Cancer , 2017, Cancers.

[7]  Yu-sheng Chen,et al.  ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior , 2016, World journal of gastroenterology.

[8]  Minoru Kanehisa,et al.  KEGG: new perspectives on genomes, pathways, diseases and drugs , 2016, Nucleic Acids Res..

[9]  A. Lánczky,et al.  miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients , 2016, Breast Cancer Research and Treatment.

[10]  Ying Cheng,et al.  Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[11]  C. Yen,et al.  Angiopoietin‐like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma , 2016, Hepatology.

[12]  K. Yanagihara,et al.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. , 2016, Oncology letters.

[13]  Gwendolyn M. Jang,et al.  Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. , 2015, Cell host & microbe.

[14]  Y. Toiyama,et al.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients. , 2015, Carcinogenesis.

[15]  C. Fan,et al.  Gene expression in “young adult type” breast cancer: a retrospective analysis , 2015, Oncotarget.

[16]  Yasuhiro Inoue,et al.  Serum Angiopoietin-like Protein 2 Improves Preoperative Detection of Lymph Node Metastasis in Colorectal Cancer. , 2015, Anticancer research.

[17]  T. Takei,et al.  Angiopoietin-like protein 2 is a potential biomarker for gastric cancer. , 2015, Molecular medicine reports.

[18]  Y. Oike,et al.  ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling , 2015, Scientific Reports.

[19]  Jinjun Li,et al.  ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma , 2015, Journal of gastroenterology and hepatology.

[20]  K. Uzawa,et al.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer , 2015, Cancer medicine.

[21]  Juancarlos Chan,et al.  Gene Ontology Consortium: going forward , 2014, Nucleic Acids Res..

[22]  Mutsushi Yamasaki,et al.  Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells , 2014, Oncology reports.

[23]  M. Fassan,et al.  An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis , 2014, Oncotarget.

[24]  Naotoshi Sugimoto,et al.  Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. , 2014, The Lancet. Oncology.

[25]  S. Fan,et al.  Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma , 2014, Molecular Cancer.

[26]  G. Gao,et al.  A motif in LILRB2 critical for Angptl2 binding and activation. , 2014, Blood.

[27]  G. Grandi,et al.  Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer , 2014, Angiogenesis.

[28]  Rick L. Evans,et al.  Classifying Patients for Breast Cancer by Detection of Autoantibodies against a Panel of Conformation-Carrying Antigens , 2014, Cancer Prevention Research.

[29]  G. Santulli.  Angiopoietin-Like Proteins: A Comprehensive Look , 2014, Front. Endocrinol..

[30]  Shabaz Mohammed,et al.  Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response , 2013, Science Signaling.

[31]  Benjamin E. Gross,et al.  Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.

[32]  Y. Jeng,et al.  Amendment history : Corrigendum ( January 2017 ) Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility , 2018 .

[33]  E. Tokunaga,et al.  Molecular Hierarchy of Heparin-Binding EGF-like Growth Factor–Regulated Angiogenesis in Triple-Negative Breast Cancer , 2013, Molecular Cancer Research.

[34]  M. Scharfe,et al.  Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion , 2012, Oncogene.

[35]  H. Sasaki,et al.  Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer. , 2012, Oncology letters.

[36]  W. Arap,et al.  A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6 , 2012, EMBO molecular medicine.

[37]  Pengcheng Zhu,et al.  Emerging Roles of Angiopoietin-like 4 in Human Cancer , 2012, Molecular Cancer Research.

[38]  Benjamin E. Gross,et al.  The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.

[39]  Xiao-tong Hu,et al.  Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. , 2012, Oncology reports.

[40]  M. Nakano,et al.  Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. , 2012, Cancer research.

[41]  Jun Xia,et al.  Upregulated INHBA expression is associated with poor survival in gastric cancer , 2012, Medical Oncology.

[42]  Ming Yao,et al.  Hypoxia‐inducible factor 1 alpha–activated angiopoietin‐like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule‐1/integrin β1 signaling in human hepatocellular carcinoma , 2011, Hepatology.

[43]  Haibo Yu,et al.  Effects of ANGPTL3 antisense oligodeoxynucleotides transfection on the cell growths and invasion of human hepatocellular carcinoma cells. , 2011, Hepato-gastroenterology.

[44]  D. Melisi,et al.  Anti-VEGF Treatment–Resistant Pancreatic Cancers Secrete Proinflammatory Factors That Contribute to Malignant Progression by Inducing an EMT Cell Phenotype , 2011, Clinical Cancer Research.

[45]  Jae Yong Cho,et al.  Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer , 2011, Clinical Cancer Research.

[46]  J. L. Ding,et al.  Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. , 2011, Cancer cell.

[47]  Wen-Chi Chou,et al.  An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer , 2010, Nucleic acids research.

[48]  Alessandro Giuliani,et al.  Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. , 2009, European journal of cancer.

[49]  M. Jeffers,et al.  Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. , 2005, Biochemical and biophysical research communications.

[50]  D. Botstein,et al.  Variation in gene expression patterns in human gastric cancers. , 2003, Molecular biology of the cell.

[51]  K. Alitalo,et al.  Tie receptors: new modulators of angiogenic and lymphangiogenic responses , 2001, Nature Reviews Molecular Cell Biology.

[52]  M. Tabata,et al.  The role of angiopoietin-like proteins in angiogenesis and metabolism. , 2008, Trends in cardiovascular medicine.

[53]  T. Barrette,et al.  ONCOMINE: a cancer microarray database and integrated data-mining platform. , 2004, Neoplasia.