Dipole Modeling of Epileptic Spikes Can Be Accurate or Misleading

Summary:  Purpose: We investigated the accuracy and potential for serious error when representing cortical generators of epileptic spikes with the common single‐dipole model. Spike generators were realistically simulated with cortical areas of different extents.

[1]  Päivi H. Laarne,et al.  Effect of EEG Electrode Density on Dipole Localization Accuracy Using Two Realistically Shaped Skull Resistivity Models , 2004, Brain Topography.

[2]  J. Gotman,et al.  A simulation study of the error in dipole source localization for EEG spikes with a realistic head model , 2003, Clinical Neurophysiology.

[3]  Jerry J Shih,et al.  Multidipole Analysis of Simulated Epileptic Spikes With Real Background Activity , 2003, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[4]  Ayako Ochi,et al.  Characteristics of dipoles in clustered individual spikes and averaged spikes , 2003, Brain and Development.

[5]  K. Ono,et al.  Is a Cortical Spike Discharge “Transferred” to the Contralateral Cortex via the Corpus Callosum?: An Intraoperative Observation of Electrocorticogram and Callosal Compound Action Potentials , 2002, Epilepsia.

[6]  Donald L Schomer,et al.  Experimental tests of EEG source localization accuracy in realistically shaped head models , 2001, Clinical Neurophysiology.

[7]  Don M. Tucker,et al.  Localizing Acute Stroke-related EEG Changes:: Assessing the Effects of Spatial Undersampling , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[8]  J. Gotman,et al.  The electroencephalogram through a software microscope: non-invasive localization and visualization of epileptic seizure activity from inside the brain , 2000, Clinical Neurophysiology.

[9]  W. Shankle,et al.  Approximating dipoles from human EEG activity: the effect of dipole source configuration on dipolarity using single dipole models , 1999, IEEE Transactions on Biomedical Engineering.

[10]  F. Mauguière,et al.  Topographical reliability of mesio-temporal sources of interictal spikes in temporal lobe epilepsy. , 1998, Electroencephalography and clinical neurophysiology.

[11]  F. H. Lopes da Silva,et al.  Biophysical aspects of EEG and magnetoencephalogram generation , 1998 .

[12]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology.

[13]  J. Ebersole.  Defining epileptogenic foci: past, present, future. , 1997, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[14]  Y. Okada,et al.  Genesis of MEG signals in a mammalian CNS structure. , 1997, Electroencephalography and clinical neurophysiology.

[15]  C. N. Guy,et al.  Intracerebral propagation of interictal activity in partial epilepsy: implications for source localisation. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[16]  F. Richer,et al.  Methodological considerations for the evaluation of spatio-temporal source models. , 1991, Electroencephalography and clinical neurophysiology.

[17]  Kazutomo Yunokuchi,et al.  Tests of EEG localization accuracy using implanted sources in the human brain , 1991, Annals of neurology.

[18]  M. Hämäläinen,et al.  Realistic conductivity geometry model of the human head for interpretation of neuromagnetic data , 1989, IEEE Transactions on Biomedical Engineering.

[19]  H. Spekreijse,et al.  Mathematical dipoles are adequate to describe realistic generators of human brain activity , 1988, IEEE Transactions on Biomedical Engineering.

[20]  M. Scherg,et al.  Two bilateral sources of the late AEP as identified by a spatio-temporal dipole model. , 1985, Electroencephalography and clinical neurophysiology.

[21]  J. Fermaglich.  Electric Fields of the Brain: The Neurophysics of EEG , 1982 .

[22]  W. Walter,et al.  COMPARISON OF SUBCORTICAL, CORTICAL AND SCALP ACTIVITY USING CHRONICALLY INDWELLING ELECTRODES IN MAN. , 1965, Electroencephalography and clinical neurophysiology.