A New Hb Variant: Hb F Sardinia γ75 (e 19) Isoieucine→Threonine Found in a Family with Hb G Philadelphia, β-Chain Deficiency and a Lepore-Like Haemoglobin Indistinguishable from Hb A2

A 59-year-old man with β -thalassaemia major is unusually well. He has no γ -chains in his haemoglobin but is heterozygous for the genes responsible for αA and for αG Philadelphi