RETRACTED: Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers

At the request of the Editors and Robert C.M. Stephens, the following article has been retracted. Robert C.M. Stephens, Catherine M.N. OMalley, Robert J. Frumento, Michael G. Mythen, and Elliott Bennett-Guerrero Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers. Journal of Endotoxin Research August 2005 11: 207–212, doi:10.1177/09680519050110040401 It has been brought to the attention of the Editor and the Publisher that a research misconduct investigation was carried out by Columbia University into allegations made against Mr Robert J. Frumento regarding the data reported in above article. The investigation concluded that Mr Frumento had fabricated data for white cell counts, platelet counts, and CRP. Please note that Journal of Endotoxin Research was the former title of Innate Immunity.

[1]  S. Opal The clinical relevance of endotoxin in human sepsis: a critical analysis , 2002, Journal of endotoxin research.

[2]  H. Harris,et al.  Endogenous lipoproteins impact the response to endotoxin in humans , 2002, Critical care medicine.

[3]  C. Bodian,et al.  Endotoxin-neutralizing capacity of serum from cardiac surgical patients. , 2001, Journal of cardiothoracic and vascular anesthesia.

[4]  T. Pollmächer,et al.  Effects of Sleep on Endotoxin-Induced Host Responses in Healthy Men , 2001, Psychosomatic medicine.

[5]  D. Reich,et al.  Decreased Endotoxin Immunity Is Associated with Greater Mortality and/or Prolonged Hospitalization after Surgery , 2001, Anesthesiology.

[6]  J. Parrillo,et al.  A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia , 2000, Critical Care Medicine.

[7]  H. D. Hochstein,et al.  Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. , 1999, The Journal of infectious diseases.

[8]  H. Eichler,et al.  Effects of Endotoxemia on Thrombopoiesis in Men , 1999, Thrombosis and Haemostasis.

[9]  W. White,et al.  Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. , 1997, JAMA.

[10]  T. van der Poll,et al.  Release of bactericidal/permeability-increasing protein in experimental endotoxemia and clinical sepsis. Role of tumor necrosis factor. , 1996, Journal of immunology.

[11]  M. Boermeester,et al.  Effect of hypertriglyceridemia on endotoxin responsiveness in humans , 1995, Infection and immunity.

[12]  S. Calvano,et al.  Influence of IL-1 receptor blockade on the human response to endotoxemia. , 1995, Journal of immunology.

[13]  A. Webb,et al.  The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction. , 1993, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[14]  D. Wilmore,et al.  Effects ofin vivo endotoxin infusions onin vitro cellular immune responses in humans , 1992, Journal of Clinical Immunology.

[15]  K. Tracey,et al.  Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Influence of elicited hormones and cytokines. , 1989, Annals of surgery.

[16]  G. Csako,et al.  Response of humans to gamma-irradiated reference Escherichia coli endotoxin. , 1989, Journal of clinical & laboratory immunology.

[17]  A. Cerami,et al.  Detection of circulating tumor necrosis factor after endotoxin administration. , 1988, The New England journal of medicine.

[18]  F. Audibert,et al.  Properties of reference Escherichia coli endotoxin and its phthalylated derivative in humans. , 1981, The Journal of infectious diseases.

[19]  E. Rackow,et al.  Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin: a prospective, double-blind, randomized, controlled trial. , 1995, Critical care medicine.