The search for physiological substrates of MAP and SAP kinases in mammalian cells.

Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.

[1]  J. Florini,et al.  The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways* , 1997, The Journal of Biological Chemistry.

[2]  E. Zackai,et al.  Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome , 1996, Nature.

[3]  A. Sharrocks,et al.  Integration of MAP kinase signal transduction pathways at the serum response element. , 1995, Science.

[4]  John C. Lee,et al.  Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase* , 1996, The Journal of Biological Chemistry.

[5]  J. Abe,et al.  Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase* , 1996, The Journal of Biological Chemistry.

[6]  R. Davis,et al.  MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway , 1996, Molecular and cellular biology.

[7]  J. Pouysségur,et al.  The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and −2 Are Induced by the p42/p44MAPK Cascade* , 1997, The Journal of Biological Chemistry.

[8]  Jerry L. Adams,et al.  A protein kinase involved in the regulation of inflammatory cytokine biosynthesis , 1994, Nature.

[9]  H. Thoenen.  Neurotrophins and Neuronal Plasticity , 1995, Science.

[10]  John C. Lee,et al.  Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. , 1997, Journal of immunology.

[11]  M. Catsicas,et al.  The phosphoprotein stathmin is essential for nerve growth factor- stimulated differentiation , 1996, The Journal of cell biology.

[12]  S. Meloche,et al.  Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells* , 1996, The Journal of Biological Chemistry.

[13]  John C. Lee,et al.  p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level. , 1997, Biochemical and biophysical research communications.

[14]  M. Gaestel,et al.  3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways , 1996, Molecular and cellular biology.

[15]  Wei Guo,et al.  Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)* , 1996, The Journal of Biological Chemistry.

[16]  Y. Granot,et al.  Stimulation of Mitogen-activated Protein Kinase and Na+/H+ Exchanger in Human Platelets , 1996, The Journal of Biological Chemistry.

[17]  J. Landry,et al.  Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. , 1997, Journal of cell science.

[18]  T. Hunter,et al.  Activation of the Sap-1a Transcription Factor by the c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.

[19]  Philip R. Cohen,et al.  PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*) , 1995, The Journal of Biological Chemistry.

[20]  A. Nordheim,et al.  Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. , 1996, Oncogene.

[21]  Philip R. Cohen,et al.  Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases , 1997, The EMBO journal.

[22]  J. Adams,et al.  Tumour necrosis factor-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils. , 1996, The Biochemical journal.

[23]  M. Su,et al.  Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors , 1997, Molecular and cellular biology.

[24]  J. Pouysségur,et al.  Cyclin D1 Expression Is Regulated Positively by the p42/p44MAPK and Negatively by the p38/HOGMAPK Pathway* , 1996, The Journal of Biological Chemistry.

[25]  Michel Morange,et al.  A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins , 1994, Cell.

[26]  Michael E. Greenberg,et al.  Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase , 1996, Science.

[27]  R. Treisman,et al.  The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c‐fos transcription in response to UV light. , 1996, The EMBO journal.

[28]  M. Goedert,et al.  SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases , 1996, FEBS letters.

[29]  Jiahuai Han,et al.  Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation , 1997, Nature.

[30]  Tony Hunter,et al.  MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates , 1997, The EMBO journal.

[31]  W. Fiers,et al.  The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor. , 1996, The EMBO journal.

[32]  J. David Sweatt,et al.  Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation* , 1996, The Journal of Biological Chemistry.

[33]  C. Clendenin,et al.  Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB , 1996, Nature.

[34]  M. May,et al.  Inhibition of MAP kinase kinase (MEK) blocks endothelial PGI2 release but has no effect on von Willebrand factor secretion or E‐selectin expression , 1996, FEBS letters.

[35]  A. Saltiel,et al.  Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*) , 1995, The Journal of Biological Chemistry.

[36]  T. Hunter,et al.  Convergence of MAP kinase pathways on the ternary complex factor Sap‐1a , 1997, The EMBO journal.

[37]  Jonathan A. Cooper,et al.  Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 , 1997, The EMBO journal.

[38]  M. Tansey,et al.  ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway , 1996, The Journal of cell biology.

[39]  John C. Lee,et al.  Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase (*) , 1996, The Journal of Biological Chemistry.

[40]  G. Johnson,et al.  Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase* , 1996, Journal of Biological Chemistry.

[41]  D. Leroith,et al.  Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways* , 1997, The Journal of Biological Chemistry.

[42]  M. Karin,et al.  Induction of c‐fos expression through JNK‐mediated TCF/Elk‐1 phosphorylation. , 1995, The EMBO journal.

[43]  C. Proud,et al.  Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway , 1996, FEBS letters.

[44]  Philip R. Cohen,et al.  The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. , 1993, The Biochemical journal.

[45]  P. Cohen,et al.  Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells. , 1997, European journal of biochemistry.

[46]  M. Gaestel,et al.  CREB is activated by UVC through a p38/HOG‐1‐dependent protein kinase , 1997, The EMBO journal.

[47]  P. Cohen,et al.  The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells. , 1995, The Biochemical journal.

[48]  Xiaozhong Wang,et al.  Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase , 1996, Science.

[49]  T. Ogihara,et al.  Elevated amyloid β protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells , 1997 .

[50]  John C. Lee,et al.  Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue (*) , 1996, The Journal of Biological Chemistry.

[51]  Bruce M. Spiegelman,et al.  Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ , 1996, Science.

[52]  M. Karin.  The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*) , 1995, The Journal of Biological Chemistry.

[53]  Jiahuai Han,et al.  The primary structure of p38 gamma: a new member of p38 group of MAP kinases. , 1996, Biochemical and biophysical research communications.

[54]  Philip R. Cohen,et al.  A comparison of the substrate specificity of MAPKAP kinase‐2 and MAPKAP kinase‐3 and their activation by cytokines and cellular stress , 1996, FEBS letters.

[55]  P. Cuatrecasas,et al.  Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin (*) , 1995, The Journal of Biological Chemistry.

[56]  Philip R. Cohen,et al.  SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1 , 1995, FEBS letters.

[57]  S. Watson,et al.  Phosphorylation and activation of cytosolic phospholipase A2 by 38-kDa mitogen-activated protein kinase in collagen-stimulated human platelets. , 1997, European journal of biochemistry.

[58]  B. Neel,et al.  Phosphorylation of Protein-tyrosine Phosphatase PTP-1B on Identical Sites Suggests Activation of a Common Signaling Pathway during Mitosis and Stress Response in Mammalian Cells* , 1997, The Journal of Biological Chemistry.

[59]  M. Greenberg,et al.  Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB , 1994, Cell.

[60]  Gaochao Zhou,et al.  Components of a New Human Protein Kinase Signal Transduction Pathway (*) , 1995, The Journal of Biological Chemistry.

[61]  J. Hsuan,et al.  Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27 , 1994, Cell.

[62]  Philip R. Cohen,et al.  Activation of stress‐activated protein kinase‐3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38) , 1997, The EMBO journal.

[63]  T. Mak,et al.  Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 , 1997, Nature.