Role of the INK4a Locus in Tumor Suppression and Cell Mortality
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[1] G. Peters,et al. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence , 1996, Molecular and cellular biology.
[2] P. Pollock,et al. Compilation of somatic mutations of the CDKN2 gene in human cancers: Non‐random distribution of base substitutions , 1996, Genes, chromosomes & cancer.
[3] N. Hayward,et al. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma , 1996, Nature Genetics.
[4] D. Louis,et al. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. , 1996, Cancer research.
[5] C. D. Edwards,et al. Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines. , 1995, Cancer research.
[6] F. Zindy,et al. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest , 1995, Cell.
[7] B. Peters,et al. Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds. , 1995, Oncogene.
[8] C. Cole,et al. The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. , 1995, Oncogene.
[9] J. Olson,et al. Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. , 1995, Cancer research.
[10] G. Hannon,et al. Deletion of the p16 and p15 genes in human bladder tumors. , 1995, Journal of the National Cancer Institute.
[11] J. Herman,et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. , 1995, Cancer research.
[12] R. Beart,et al. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. , 1995, Cancer research.
[13] P. Goodfellow,et al. Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. , 1995, The New England journal of medicine.
[14] A M Goldstein,et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. , 1995, The New England journal of medicine.
[15] N. Hayward,et al. Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds. , 1995, Human molecular genetics.
[16] Kathleen R. Cho,et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours , 1995, Nature Genetics.
[17] C. Busch,et al. High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder. , 1995, Journal of the National Cancer Institute.
[18] M. Loda,et al. CDC25 phosphatases as potential human oncogenes. , 1995, Science.
[19] L. Cannon-Albright,et al. Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. , 1995, Oncogene.
[20] M. Serrano,et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma , 1995, Science.
[21] M. Williamson,et al. p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer. , 1995, Human molecular genetics.
[22] G. Hannon,et al. Cloning and characterization of murine p16INK4a and p15INK4b genes. , 1995, Oncogene.
[23] H. Koeffler,et al. Role of the cyclin-dependent kinase inhibitors in the development of cancer. , 1995, Blood.
[24] P. Stanley,et al. WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[25] E. Hovig,et al. Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. , 1995, British Journal of Cancer.
[26] S. Tavtigian,et al. Complex structure and regulation of the P16 (MTS1) locus. , 1995, Cancer research.
[27] C. D. Edwards,et al. A novel p16INK4A transcript. , 1995, Cancer research.
[28] R. Berger,et al. A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. , 1995, Oncogene.
[29] R. Weinberg,et al. Growth suppression by p16ink4 requires functional retinoblastoma protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[30] L. Sandkuijl,et al. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds , 1995, Nature Genetics.
[31] S. Hanai,et al. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. , 1995, Cancer research.
[32] B. Dynlacht,et al. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition , 1995, Nature.
[33] J. Bartek,et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 , 1995, Nature.
[34] James M. Roberts,et al. Inhibitors of mammalian G1 cyclin-dependent kinases. , 1995, Genes & development.
[35] R. Weinberg,et al. The retinoblastoma protein and cell cycle control , 1995, Cell.
[36] J. Bartek,et al. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity , 1995, Molecular and cellular biology.
[37] David O. Morgan,et al. Principles of CDK regulation , 1995, Nature.
[38] C. D. Edwards,et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. , 1995, Cancer research.
[39] R. DePinho,et al. Inhibition of ras-induced proliferation and cellular transformation by p16INK4 , 1995, Science.
[40] A. Okamoto,et al. IS-12 Mutation and altered expression of P16^ in human cancer. , 1995 .
[41] G. Reifenberger,et al. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. , 1994, Cancer research.
[42] C. O'keefe,et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. , 1994, Genes & development.
[43] M. Kripke,et al. Ultraviolet radiation and immunology: something new under the sun--presidential address. , 1994, Cancer research.
[44] T. Hunter,et al. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.
[45] A. Okamoto,et al. Mutations and altered expression of p16INK4 in human cancer. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[46] D. Housman,et al. p53 status and the efficacy of cancer therapy in vivo. , 1994, Science.
[47] W. Clark,et al. Germline p16 mutations in familial melanoma , 1994, Nature Genetics.
[48] Gregory J. Hannon,et al. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest , 1994, Nature.
[49] A. Kamb. A cell cycle regulator potentially involved in genesis of many tumour types , 1994 .
[50] D. Carson,et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers , 1994, Nature.
[51] M. Skolnick,et al. A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.
[52] C. Cordon-Cardo,et al. Expression of the retinoblastoma protein is regulated in normal human tissues. , 1994, The American journal of pathology.
[53] E. Harlow,et al. Identification of G1 kinase activity for cdk6, a novel cyclin D partner , 1994, Molecular and cellular biology.
[54] L. Bonetta,et al. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. , 1994, Oncogene.
[55] G. Hannon,et al. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.
[56] C. Harris,et al. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[57] D. Beach,et al. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. , 1993, Genes & development.
[58] Hui Zhang,et al. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA , 1992, Cell.
[59] Steven K. Hanks,et al. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins , 1992, Cell.
[60] A. Berns,et al. Requirement for a functional Rb-1 gene in murine development , 1992, Nature.
[61] R. Weinberg,et al. Effects of an Rb mutation in the mouse , 1992, Nature.
[62] A. Bradley,et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.
[63] U. Rapp,et al. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. , 1992, Genes & development.
[64] R. Bronson,et al. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene , 1991, Cell.
[65] B. Futcher,et al. Human D-type cyclin , 1991, Cell.
[66] Richard A. Ashmun,et al. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle , 1991, Cell.
[67] A. Arnold,et al. A novel cyclin encoded by a bcl1-linked candidate oncogene , 1991, Nature.
[68] Jan C. van der Leun,et al. Development of skin tumors in hairless mice after discontinuation of ultraviolet irradiation. , 1991 .
[69] T. Hunter. Cooperation between oncogenes , 1991, Cell.
[70] M. Bradl,et al. Malignant melanoma in transgenic mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[71] J. DiGiovanni. Modification of multistage skin carcinogenesis in mice. , 1991, Progress in experimental tumor research.
[72] H. Ruley. Transforming collaborations between ras and nuclear oncogenes. , 1990, Cancer cells.
[73] S. Palmieri. Oncogene requirements for tumorigenicity: cooperative effects between retroviral oncogenes. , 1989, Current topics in microbiology and immunology.
[74] L. S. Cram,et al. Spontaneous immortalization rate of cultured Chinese hamster cells. , 1986, Journal of the National Cancer Institute.
[75] R. Newbold,et al. Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene , 1983, Nature.
[76] Robert A. Weinberg,et al. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.
[77] D. Röhme. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[78] W. Silvers. The Coat Colors of Mice , 1979, Springer New York.
[79] C. D. Edwards,et al. Multiple Mechanisms of p 16 @ NK 4 AInactivation in Non-Small Cell Lung Cancer Cell Lines , 2022 .