Quantification and characterization of grouped type I myofibers in human aging

Myofiber type grouping is a histological hallmark of age‐related motor unit remodeling. Despite the accepted concept that denervation–reinnervation events lead to myofiber type grouping, the completeness of those conversions remains unknown.

[1]  S. Hussain,et al.  Failed reinnervation in aging skeletal muscle , 2016, Skeletal Muscle.

[2]  C. Rice,et al.  Innervation and neuromuscular control in ageing skeletal muscle , 2016, The Journal of physiology.

[3]  G. Many,et al.  Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro. , 2016, American journal of physiology. Endocrinology and metabolism.

[4]  M. Gaweł,et al.  Effect of Age and Gender on the Number of Motor Units in Healthy Subjects Estimated by the Multipoint Incremental MUNE Method , 2014, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[5]  C. S. Bickel,et al.  Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's disease. , 2014, Journal of applied physiology.

[6]  C. Reggiani,et al.  Mechanisms modulating skeletal muscle phenotype. , 2013, Comprehensive Physiology.

[7]  David J. Kosek,et al.  Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. , 2013, Journal of applied physiology.

[8]  K. Choi,et al.  Sarcopenia: Definition, Epidemiology, and Pathophysiology , 2013, Journal of bone metabolism.

[9]  M. Bamman,et al.  Characterization and regulation of mechanical loading-induced compensatory muscle hypertrophy. , 2012, Comprehensive Physiology.

[10]  David G. Behm,et al.  Motor unit number estimates in masters runners: use it or lose it? , 2010, Medicine and science in sports and exercise.

[11]  J. Petrella,et al.  Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis. , 2008, Journal of applied physiology.

[12]  M. Bubenheim,et al.  Morphologic changes in the vastus medialis muscle in patients with osteoarthritis of the knee. , 2007, Arthritis and rheumatism.

[13]  David J. Kosek,et al.  Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women. , 2006, American journal of physiology. Endocrinology and metabolism.

[14]  David J. Kosek,et al.  Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. , 2006, Journal of applied physiology.

[15]  J. Cross,et al.  Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. , 2005, American journal of physiology. Endocrinology and metabolism.

[16]  Daniel W Stashuk,et al.  Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men , 2005, Muscle & nerve.

[17]  K. Vehkalahti,et al.  Cluster Analysis , 2002, Science.

[18]  J. Lexell,et al.  Human aging, muscle mass, and fiber type composition. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  K. Kanda,et al.  Changes in properties of the medial gastrocnemius motor units in aging rats. , 1989, Journal of neurophysiology.

[20]  M. Sjöström,et al.  What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men , 1988, Journal of the Neurological Sciences.

[21]  J Lexell,et al.  Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections , 1983, Muscle & nerve.

[22]  J. Eccles,et al.  Differentiation of fast and slow muscles in the cat hind limb , 1960, The Journal of physiology.

[23]  J. Eccles,et al.  Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses , 1960, The Journal of physiology.

[24]  C. Jankowski Exercise Dosing to Retain Resistance Training Adaptations in Young and Older Adults , 2012 .

[25]  D. Downham,et al.  The occurrence of fibre-type grouping in healthy human muscle: a quantitative study of cross-sections of whole vastus lateralis from men between 15 and 83 years , 2004, Acta Neuropathologica.

[26]  D. Downham,et al.  Morphological detection of neurogenic muscle disorders: how can statistical methods aid diagnosis? , 2004, Acta Neuropathologica.

[27]  M. Castro,et al.  Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury. , 2002, Journal of applied physiology.

[28]  Sung Gyoo Park Medicine and Science in Sports and Exercise , 1981 .