Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease

Recent experimental evidences suggest protective and trophic effects of ginseng in the memory function of Alzheimer disease (AD). Thus, we investigated the clinical efficacy of Panax ginseng in the cognitive performance of AD patients in an open-label study. Consecutive AD patients were randomly assigned to the ginseng (n=58) or the control group (n=39), and the ginseng group was treated with Panax ginseng powder (4.5 g/d) for 12 weeks. Cognitive performances were monitored using the mini-mental state examination (MMSE) and Alzheimer disease assessment scale (ADAS) during 12 weeks of the ginseng treatment and at 12 weeks after the ginseng discontinuation. MMSE and ADAS scales showed no baseline difference between the groups. After ginseng treatment, the cognitive subscale of ADAS and the MMSE score began to show improvements and continued up to 12 weeks (P=0.029 and P=0.009 vs. baseline, respectively). After discontinuing ginseng, the improved ADAS and MMSE scores declined to the levels of the control group. These results suggest that Panax ginseng is clinically effective in the cognitive performance of AD patients (ClinicalTrials.gov Identifier: NCT00391833).

[1]  Katsuko Komatsu,et al.  Search for Natural Products Related to Regeneration of the Neuronal Network , 2005, Neurosignals.

[2]  D. Kennedy,et al.  Dose Dependent Changes in Cognitive Performance and Mood following Acute Administration of Ginseng to Healthy Young Volunteers , 2001, Nutritional neuroscience.

[3]  D. Kennedy,et al.  Ginseng: potential for the enhancement of cognitive performance and mood , 2003, Pharmacology Biochemistry and Behavior.

[4]  K. Nam.  The Comparative Understanding between Red Ginseng and White Ginsengs, Processed Ginsengs (Panax ginseng C. A. Meyer) , 2005 .

[5]  Sum-Yan Ng,et al.  Effects of ginseng saponins on β-amyloid-induced amnesia in rats , 2006 .

[6]  G. Wilcock,et al.  Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial , 2000, BMJ : British Medical Journal.

[7]  Yong Cheng,et al.  Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action , 2005, Acta Pharmacologica Sinica.

[8]  M. Meselhy,et al.  Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins , 2004, Neuropsychopharmacology.

[9]  S. Joo,et al.  Potential effects of microglial activation induced by ginsenoside Rg3 in rat primary culture: Enhancement of type a macrophage scavenger receptor expression , 2005, Archives of pharmacal research.

[10]  J. L. Stringer,et al.  Protective effects of ginseng components in a rodent model of neurodegeneration , 2005, Annals of neurology.

[11]  B. McEwen,et al.  Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. , 1997, Brain research. Molecular brain research.

[12]  W. F. Mcdaniel,et al.  Ginseng improves strategic learning by normal and brain‐damaged rats , 1998, Neuroreport.

[13]  K. Chiba,et al.  Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice. , 2001, Biological & pharmaceutical bulletin.

[14]  Cuk-Seong Kim,et al.  Effect of Korea red ginseng on cerebral blood flow and superoxide production. , 2002, Acta pharmacologica Sinica.

[15]  N. Nishiyama,et al.  Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats , 1994, Brain Research.

[16]  M. Marcoli,et al.  A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. , 1986, Journal of ethnopharmacology.

[17]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[18]  J. Fitzloff,et al.  HPLC DETERMINATION OF GINSENOSIDES CONTENT IN GINSENG DIETARY SUPPLEMENTS USING ULTRAVIOLET DETECTION , 2002 .

[19]  M. Sakanaka,et al.  Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root , 1997, Neuroscience Research.

[20]  C. Yuan,et al.  Ginseng pharmacology: multiple constituents and multiple actions. , 1999, Biochemical pharmacology.

[21]  David D. Kitts,et al.  Antioxidant properties of a North American ginseng extract , 2004, Molecular and Cellular Biochemistry.

[22]  E. Perry,et al.  Non‐ginsenoside nicotinic activity in ginseng species , 1999, Phytotherapy research : PTR.

[23]  Kinzo Matsumoto,et al.  Panax ginseng extract improves the scopolamine-induced disruption of 8-arm radial maze performance in rats. , 1995, Biological & pharmaceutical bulletin.

[24]  남기열.  The Comparative Understanding between Red Ginseng and White Ginsengs,Processed Ginsengs (Panax ginseng C. A. Meyer) , 2005 .

[25]  J. H. Boo,et al.  Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice , 2001, Journal of neuroscience research.

[26]  T. Ono,et al.  Effects of nonsaponin fraction of red ginseng on learning deficits in aged rats , 2004, Physiology & Behavior.

[27]  K. Davis,et al.  A new rating scale for Alzheimer's disease. , 1984, The American journal of psychiatry.

[28]  G. Wilcock,et al.  Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group. , 2000, BMJ.

[29]  K. Kudo,et al.  Effects of ginseng saponins on responses induced by various receptor stimuli. , 1999, European journal of pharmacology.

[30]  J. Sonne,et al.  A DOUBLE-MASKED STUDY OF THE EFFECTS OF GINSENG ON COGNITIVE FUNCTIONS , 1996 .

[31]  C. Eckman,et al.  Reductions in levels of the Alzheimer's amyloid β peptide after oral administration of ginsenosides , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  Li-hong Shen,et al.  Ginsenoside Rg1 promotes proliferation of hippocampal progenitor cells , 2004, Neurological research.