Antigen Antibody Interactions

1. Introduction.- 1. Organization of the Immune System.- 2. Antibody Structure.- 3. The Theory of Clonal Selection.- 2. Hinge and Valence Effects on Antibody Binding Properties.- 1. General Considerations.- 2. The Two-Particle Probability Density Function.- 3. The Crothers-Metzger Model.- 4. Analysis of Experiments.- 5. Immunological Implications.- 3. Combining site heterogeneity. The free energy distribution function.- 1. Statement of the Problem.- 2. Inversion of the Binding Curve.- 3. Intramolecular Reactions.- 4. Immunological Implications.- 4. Combining Site Heterogeneity. Immunodiffusion.- 1. General Remarks.- 2. A Simple Diffusion-Reaction Model for Plaque Formation.- 2.1 Basic Concepts.- 2.2 The Equations.- 2.3 The Plaque Radius.- 3. The Solution.- 4. Applications.- 4.1 Estimation of the Diffusion Coefficient.- 4.2 Estimation of Average Affinity.- 5. The Theory of Plaque Growth Kinetics For A Lymphocyte SOURCE.- 1. Introduction.- 2. A Diffusion-Reaction Model.- 3. Solutions Under Limiting Conditions.- 3.1 The n-Dimensional Green1 s Function.- 3.2 The Solution in Three Dimensions.- 3.3 The Solution in Two Dimensions.- 4. Models Allowing Reversible Reactions.- 5. A Diffusion-Transport-Reaction Model. Electrophoresis.- 6. Predictions of the Theory.- 6.1 Constraints on Parameters.- 6.2 Plaque Growth Characteristics. Comparison With Experiment.- 6. Plaque Inhibition: Growth In The Presence Of Competitive Interactions.- 1. Introduction.- 2. IgG Plaque Inhibition.- 2.1 A Generalized Diffusion-Reaction Model.- 2.2 Inhibition by Univalent Molecules.- 2.3 Inhibition by Multivalent Molecules.- 3. Predictions.- 7. Applications Of Plaque Growth Theory And Immunological Implications.- 1. The IgM Response.- 2. The IgG Response.- 3. Summary of Conclusions.- 8. Dynamical Phenomena on Lymphocyte Membranes.- 1. Background and Definitions.- 2. The Dynamics of Antigen-Antibody Aggregation in Three Dimensions.- 2.1 The Aggregate Size Distribution Function.- 2.2 The Role of Diffusion.- 2.3 Aggregation as a Branching Process. Critical Behavior.- 3. Critical Coalescence on Lymphocyte Membranes.- 4. Immunological Implications of the Model.- 5. Future Problems.