Strategies to target tumors using nanodelivery systems based on biodegradable polymers, aspects of intellectual property, and market

Abbreviations 2DG 2-Deoxy-D-glucose A10 RNA aptamer A10 2′-fluoropyrimidine RNA aptamer ACTH Adrenocorticotropin hormone CRF Corticotropin releasing factor CS Chitosan DCC N,N′-dicyclohexylcarbodiimide EDC 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride EPR Enhanced permeability and retention FOL Folic acid HER Human epidermal receptors MRI Magnetic resonance imaging NHS N-Hydroxysuccinimide PCL Poly(ε-caprolactone) PDGFR Platelet-derived growth factor receptor PEG Poly(ethylene glycol) PET Positron emission tomography PGA Poly(glycolic acid) PLA Poly(lactic acid) PLGA Poly(lactic-co-glycolic) PLL Poly(L-lysine) PSMA Prostate-specific membrane antigen siRNA Small interfering RNA SPECT Single photon emission computed tomography TPGS D-α-tocopheryl polyethylene glycol succinate VCAM-1 Vascular cell adhesion molecule-1 VEGFR Endothelial growth factor receptors WGA Wheat germ agglutinin

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