High sensitivity label-free refractometer based biosensor applicable to glycated hemoglobin detection in human blood using all-circular photonic crystal ring resonators

Abstract Lab-on-a-chip integrated optical biosensors have shown useful in non-invasive detection of biomaterials. Furthermore they are immune to electromagnetic interference rather than their electronic counterparts. In this paper, an all-optical photonic crystal (PhC)-based biosensor is presented. The biosensor is made up of two PhC-based W 1 waveguides which are critically coupled to a PhC-based ring-resonator (RR). The hub of the ring is designed in an all-circular quasi-crystal fashion to enhance output efficiency as well as easy injection of analyte. This PhCRR can distinguish 85 ± 15% of amplitude change via resonant wavelength shift of 0.75 ± 0.15 nm, or equally a 0.005 change in the refractive index unit (RIU). By introducing any change in the optical characteristics of desired biomaterials (i.e. refractive index of glycated hemoglobin), the resonance frequency of resonator changes and due to its high quality factor and sensitivity, a large amplitude difference appears in the output. The proposed glycated hemoglobin biosensor works in the wavelength interval of 1.545–1. 565 μ m , and its quality factor, figure of merit (FOM) and sensitivity are calculated to be 2500 ± 500 , 1400 ± 200 RIU−1 and 690 ± 50 nm/RIU, respectively. The simulations are performed in two-dimensional and finite difference time domain (FDTD) algorithm is used to numerically solve time-dependent Maxwell-equations within propagation domain.

[1]  Valery V. Tuchin,et al.  Investigation of glucose-hemoglobin interaction by optical coherence tomography , 2007, Saratov Fall Meeting.

[2]  A. Rostami,et al.  3-D Numerical Analysis of Smith–Purcell-Based Terahertz Wave Radiation Excited by Effective Surface Plasmon , 2015, Journal of Lightwave Technology.

[3]  Alireza Andalib,et al.  A novel proposal for all-optical Galois field adder based on photonic crystals , 2018, Photonic Network Communications.

[4]  F. Parandin,et al.  Line defects on As 2 Se 3 -Chalcogenide photonic crystals for the design of all-optical power splitters and digital logic gates , 2017 .

[5]  Alireza Tavousi,et al.  Study on the similarity of photonic crystal ring resonator cavity modes and whispering-gallery-like modes in order to design more efficient optical power dividers , 2015, Photonic Network Communications.

[6]  A. Dolatabady,et al.  Tunable Mid-Infrared Nanoscale Graphene-Based Refractive Index Sensor , 2018, IEEE Sensors Journal.

[7]  Alireza Tavousi,et al.  Performance evaluation of photonic crystal ring resonators based optical channel add-drop filters with the aid of whispering gallery modes and their Q-factor , 2015 .

[8]  A. Dolatabady,et al.  Plasmonic Magnetic Sensor Based on Graphene Mounted on a Magneto-Optic Grating , 2018, IEEE Transactions on Magnetics.

[9]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[10]  S. Robinson,et al.  Nano-Pressure and Temperature Sensor Based on Hexagonal Photonic Crystal Ring Resonator , 2019, Plasmonics.

[11]  Alireza Tavousi,et al.  Flat-Band Slow Light in a Photonic Crystal Slab Waveguide by Vertical Geometry Adjustment and Selective Infiltration of Optofluidics , 2017, Journal of Electronic Materials.

[12]  H. Alipour-Banaei,et al.  Proposal for realizing an all-optical half adder based on photonic crystals. , 2018, Applied optics.

[13]  Mohammad Ali Mansouri-Birjandi,et al.  Engineering Hexagonal Array of Nanoholes for High Sensitivity Biosensor and Application for Human Blood Group Detection , 2018, IEEE Transactions on Nanotechnology.

[14]  Alireza Tavousi,et al.  Full-optical tunable add/drop filter based on nonlinear photonic crystal ring resonators , 2016 .

[15]  M. Erim,et al.  Biosensing With Asymmetric High Refractive Index Contrast Gratings , 2016, IEEE Sensors Journal.

[16]  H. Heidarzadeh,et al.  Realization of a multichannel drop filter using an ISO-centric all-circular photonic crystal ring resonator , 2018, Photonics and Nanostructures - Fundamentals and Applications.

[17]  The effect of anisotropy on light extraction of organic light-emitting diodes with photonic crystal structure , 2013 .

[18]  Mark A Lifson,et al.  Selective virus detection in complex sample matrices with photonic crystal optical cavities. , 2013, Biosensors & bioelectronics.

[19]  N. Rangaswamy,et al.  Bandstop filter for photonic integrated circuits using photonic crystal with circular ring resonator , 2011 .

[20]  R. Nakkeeran,et al.  Performance evaluation of PCRR based add drop filter with different rod shapes , 2012 .

[21]  L. Andreani,et al.  Silicon-based two-dimensional photonic crystal waveguides , 2003 .

[22]  Ming-Chuan Leu,et al.  Progress in Additive Manufacturing and Rapid Prototyping , 1998 .

[23]  Steven G. Johnson,et al.  Molding the flow of light , 2001, Comput. Sci. Eng..

[24]  Ebrahim Farshidi,et al.  Ultra-fast analog-to-digital converter based on a nonlinear triplexer and an optical coder with a photonic crystal structure. , 2017, Applied optics.

[25]  Itamar Willner,et al.  Label-free and reagentless aptamer-based sensors for small molecules. , 2006, Journal of the American Chemical Society.

[26]  Ryan M. Pearson,et al.  Structural Color for Additive Manufacturing: 3D-Printed Photonic Crystals from Block Copolymers. , 2017, ACS nano.

[27]  Alireza Tavousi,et al.  Successive approximation-like 4-bit full-optical analog-to-digital converter based on Kerr-like nonlinear photonic crystal ring resonators , 2016 .

[28]  Alireza Tavousi,et al.  Optical-analog-to-digital conversion based on successive-like approximations in octagonal-shape photonic crystal ring resonators , 2017 .

[29]  Shuren Hu,et al.  Porous silicon ring resonator for compact, high sensitivity biosensing applications. , 2015, Optics express.

[30]  E. Chow,et al.  Ultra compact biochemical sensor built with two dimensional photonic crystal microcavity , 2004, InternationalQuantum Electronics Conference, 2004. (IQEC)..

[31]  K. Fasihi,et al.  A highly-sensitive label-free biosensor based on two dimensional photonic crystals with negative refraction , 2017 .

[32]  Ray T. Chen,et al.  Slow light engineering for high Q high sensitivity photonic crystal microcavity biosensors in silicon. , 2012, Biosensors & bioelectronics.

[33]  P. Yeh,et al.  Optical Waves in Layered Media , 1988 .

[34]  Label-free detection of glycated haemoglobin in human blood using silicon-based photonic crystal nanocavity biosensor , 2016 .

[35]  Ebrahim Farshidi,et al.  All optical 2-bit analog to digital converter using photonic crystal based cavities , 2017 .

[36]  A. Rostami,et al.  Proposal for Simultaneous Two-Color Smith–Purcell Terahertz Radiation Through Effective Surface Plasmon Excitation , 2017, IEEE Journal of Selected Topics in Quantum Electronics.

[37]  A. Parini,et al.  2D or 3D FDTD Modeling of Photonic Crystal Waveguides , 2004 .

[38]  J. R. Salgueiro,et al.  3D printing of Al2O3 photonic crystals for terahertz frequencies , 2016 .

[39]  Lars Hagedorn Frandsen,et al.  Silicon photonic crystal nanostructures for refractive index sensing , 2008 .

[40]  Nicolas H Voelcker,et al.  Porous silicon biosensors on the advance. , 2009, Trends in biotechnology.

[41]  Kestutis Staliunas,et al.  Mid-infrared T-shaped photonic crystal waveguide for optical refractive index sensing , 2017 .

[42]  Dennis W Prather,et al.  Plane-wave expansion method for calculating band structure of photonic crystal slabs with perfectly matched layers. , 2004, Journal of the Optical Society of America. A, Optics, image science, and vision.

[43]  H. Salemink,et al.  Photonic crystal-based all-optical on-chip sensor. , 2012, Optics express.

[44]  C. Consani,et al.  Sensitivity optimization of a photonic crystal ring resonator for gas sensing applications , 2017 .

[45]  S. John,et al.  Optical Biosensing of Multiple Disease Markers in a Photonic-Band-Gap Lab-on-a-Chip: A Conceptual Paradigm , 2015 .

[46]  S. Arnold,et al.  Whispering-gallery-mode biosensing: label-free detection down to single molecules , 2008, Nature Methods.

[47]  Aric Shorey,et al.  Glass wafer mechanical properties: A comparison to silicon , 2011, 2011 6th International Microsystems, Packaging, Assembly and Circuits Technology Conference (IMPACT).

[48]  S. Weiss,et al.  Current status and outlook for silicon-based optical biosensors , 2009 .

[49]  L. Frandsen,et al.  Photonic crystal nanostructures for optical biosensing applications. , 2009, Biosensors & bioelectronics.

[50]  Yanlin Song,et al.  Inkjet Printing of Photonic Crystals , 2017 .

[51]  Lan Yang,et al.  Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices , 2012 .

[52]  Martina Gerken,et al.  Photonic crystal biosensors towards on‐chip integration , 2012, Journal of biophotonics.

[53]  M. Lipson,et al.  On-chip gas detection in silicon optical microcavities , 2008, 2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science.

[54]  Yuefeng Ji,et al.  Nanoscale photonic crystal sensor arrays on monolithic substrates using side-coupled resonant cavity arrays. , 2011, Optics express.

[55]  Brian T Cunningham,et al.  Label-free cell-based assays using photonic crystal optical biosensors. , 2011, The Analyst.

[56]  Steven G. Johnson,et al.  Photonic Crystals: Molding the Flow of Light , 1995 .

[57]  D. Storti,et al.  Additive manufacturing of mechanochromic polycaprolactone on entry-level systems , 2015 .

[58]  A. Cerami,et al.  Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. , 1976, The New England journal of medicine.

[59]  Costas M. Soukoulis,et al.  Photonic Crystals and Light Localization in the 21st Century , 2001 .

[60]  Farhad Mehdizadeh,et al.  A new proposal for PCRR-based channel drop filter using elliptical rings , 2014 .