Efficacy of the Newcastle disease vaccine on the control of bovine papilomatosis

The efficacy of Newcastle disease virus La Sota strain (NDV-LS) attenuated vaccine for treating bovine papillomatosis was evaluated. A total of 64 crossbreed female dairy cattle with clinically diagnosed skin papillomatosis, reared in farms of Alto Mayo, San Martín, Peru were used in the study. A group of 34 animals were subcutaneously inoculated with 2 ml of NDV-LS attenuated vaccine (109 infective dose50 in egg) on day 0 and day 7, and were clinically evaluated on days 0, 7, 30, 45, and 60 after inoculation. The remainder animals were kept as controls. Effective treatment was considered when at least 75% of papillomas successfully underwent to regression. Evaluation on day 60 showed the treatment to be effective in three animals (8.8%). No statistical difference was found with

[1]  A. C. Freitas,et al.  Papillomavirus DNA detection in non epithelial tissues: a discussion about bovine papillomavirus , 2007 .

[2]  L. Silva,et al.  Eficiência da repetição de diferentes protocolos de tratamentos para Papilomatose bovina , 2004 .

[3]  W. Liang,et al.  Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive tract. , 2003, World journal of gastroenterology.

[4]  M. Campo,et al.  Animal models of papillomavirus pathogenesis. , 2002, Virus research.

[5]  V. Schirrmacher,et al.  Antitumor effects of Newcastle Disease Virus in vivo: local versus systemic effects. , 2001, International journal of oncology.

[6]  O. Wildner.  Oncolytic viruses as therapeutic agents , 2001, Annals of medicine.

[7]  L. Bai,et al.  Newcastle disease virus activates macrophages for anti-tumor activity. , 2000, International journal of oncology.

[8]  T. Bakács,et al.  Use of Newcastle disease virus vaccine (MTH-68/H) in a patient with high-grade glioblastoma. , 1999, JAMA.

[9]  R. Zawatzky,et al.  Tumor stimulator cell modification by infection with Newcastle Disease Virus: analysis of effects and mechanism in MLTC-CML cultures. , 1999, International journal of oncology.

[10]  W. Rebhun.  Enfermedades del ganado vacuno lechero , 1999 .

[11]  T. Bakács,et al.  Beneficial treatment of patients with advanced cancer using a Newcastle disease virus vaccine (MTH-68/H). , 1999, Anticancer research.

[12]  T Grandin,et al.  Assessment of stress during handling and transport. , 1997, Journal of animal science.

[13]  T. Kamińska,et al.  In vitro and in vivo interferon production by bovine colostral leukocytes. , 1995, DTW. Deutsche tierarztliche Wochenschrift.

[14]  M. Campo,et al.  Latent papillomavirus infection in cattle. , 1994, Research in veterinary science.

[15]  B. Bodey,et al.  Attenuated veterinary virus vaccine for the treatment of cancer. , 1993, Cancer detection and prevention.

[16]  K.V.F. Kennedy Jubb.  Patología de los animales domésticos , 1991 .