Photonic crystal biosensors towards on‐chip integration

Photonic crystal technology has attracted large interest in the last years. The possibility to generate highly sensitive sensor elements with photonic crystal structures is very promising for medical or environmental applications. The low-cost fabrication on the mass scale is as advantageous as the compactness and reliability of photonic crystal biosensors. The possibility to integrate microfluidic channels together with photonic crystal structures allows for highly compact devices. This article reviews different types of photonic crystal sensors including 1D photonic crystal biosensors, biosensors with photonic crystal slabs, photonic crystal waveguide biosensors and biosensors with photonic crystal microcavities. Their applications in biomolecular and pathogen detection are highlighted. The sensitivities and the detection limits of the different biosensors are compared. The focus is on the possibilities to integrate photonic crystal biosensors on-chip.

[1]  David G Myszka,et al.  Analysis of small-molecule interactions using Biacore S51 technology. , 2004, Analytical biochemistry.

[2]  S. Xiao,et al.  Liquid-infiltrated photonic crystals: enhanced light-matter interactions for lab-on-a-chip applications , 2007, 0707.1194.

[3]  Ray T. Chen,et al.  Silicon nano-membrane based photonic crystal microcavities for high sensitivity bio-sensing. , 2012, Optics letters.

[4]  E. Chow,et al.  Ultra compact biochemical sensor built with two dimensional photonic crystal microcavity , 2004, InternationalQuantum Electronics Conference, 2004. (IQEC)..

[5]  G Gauglitz,et al.  Affinity detection of low molecular weight analytes. , 1996, Analytical chemistry.

[6]  P. Fauchet,et al.  Two-dimensional silicon photonic crystal based biosensing platform for protein detection. , 2007, Optics express.

[7]  Y. Peter,et al.  Guided-mode resonance photonic crystal slab sensors based on bead monolayer geometry. , 2008, Optics express.

[8]  H. C. Pedersen,et al.  Optical waveguide sensor for on-line monitoring of bacteria. , 2003, Optics letters.

[9]  Peichen Yu,et al.  Fluid detection with photonic crystal-based multichannel waveguides , 2003 .

[10]  Jacques Mugnier,et al.  Eu3+-doped microcavities fabricated by sol–gel process , 2001 .

[11]  B. Cunningham,et al.  Photonic crystal optical biosensor incorporating structured low-index porous dielectric , 2005, IEEE Sensors, 2005..

[12]  Soon-Hong Kwon,et al.  Optimization of photonic crystal cavity for chemical sensing. , 2008, Optics express.

[13]  E. Yablonovitch,et al.  Inhibited spontaneous emission in solid-state physics and electronics. , 1987, Physical review letters.

[14]  Y. Peter,et al.  Tunable structures comprising two photonic crystal slabs--optical study in view of multi-analyte enhanced detection. , 2009, Optics express.

[15]  N. Zaytseva,et al.  Microfluidic resonant waveguide grating biosensor system for whole cell sensing , 2011 .

[16]  Christian Drosten,et al.  Rapid Detection and Quantification of RNA of Ebola and Marburg Viruses, Lassa Virus, Crimean-Congo Hemorrhagic Fever Virus, Rift Valley Fever Virus, Dengue Virus, and Yellow Fever Virus by Real-Time Reverse Transcription-PCR , 2002, Journal of Clinical Microbiology.

[17]  B. Cunningham,et al.  Colorimetric resonant reflection as a direct biochemical assay technique , 2002, Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266).

[18]  J Furness.  The peace dividend. Part I. , 1994, Medical device technology.

[19]  Michael Scalora,et al.  Transmissive properties of Ag/MgF2 photonic band gaps , 1998 .

[20]  Lance G. Laing,et al.  Label-Free Assays on the BIND System , 2004, Journal of biomolecular screening.

[21]  Y. An,et al.  Concise review of mechanisms of bacterial adhesion to biomaterial surfaces. , 1998, Journal of biomedical materials research.

[22]  S.P. Mohanty,et al.  Biosensors: a tutorial review , 2006, IEEE Potentials.

[23]  Solomon Assefa,et al.  Photonic crystal slab sensor with enhanced surface area. , 2010, Optics express.

[24]  M. Galli,et al.  Optical response of one-dimensional (Si/SiO2)m photonic crystals , 2002 .

[25]  A. Scherer,et al.  Waveguiding in Planar Photonic Crystals , 2000 .

[26]  B. Cunningham,et al.  Rapid Specific and Label-Free Detection of Porcine Rotavirus Using Photonic Crystal Biosensors , 2009, IEEE Sensors Journal.

[27]  Guohong Ma,et al.  Ultrafast all-optical switching in one-dimensional photonic crystal with two defects. , 2006, Optics express.

[28]  Charles J. Choi,et al.  Single-step fabrication and characterization of photonic crystal biosensors with polymer microfluidic channels. , 2006, Lab on a chip.

[29]  T. Krauss,et al.  Temperature stabilization of optofluidic photonic crystal cavities , 2009 .

[30]  B. Cunningham,et al.  High Sensitivity Plastic-Substrate Photonic Crystal Biosensor , 2008, IEEE Sensors Journal.

[31]  E. Engvall,et al.  Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. , 1971, Immunochemistry.

[32]  D. Erickson,et al.  Nanoscale optofluidic sensor arrays. , 2008, Optics express.

[33]  H. Lin,et al.  Ultrasensitive guided-mode resonance biosensors superimposed with vertical-sidewall roughness. , 2011, Applied optics.

[34]  Brian T. Cunningham,et al.  Large-area submicron replica molding of porous low-k dielectric films and application to photonic crystal biosensor fabrication , 2007 .

[35]  Günter Gauglitz,et al.  Surface plasmon resonance sensors: review , 1999 .

[36]  K. Hirao,et al.  Optical properties of a total-reflection-type one-dimensional photonic crystal , 2002 .

[37]  Steven G. Johnson,et al.  Photonic Crystals: Molding the Flow of Light - Second Edition , 2008 .

[38]  Lech Wosinski,et al.  Pillar-array based optical sensor. , 2010, Optics express.

[39]  Philippe M. Fauchet,et al.  Microcavities in photonic crystal waveguides for biosensor applications , 2010, BiOS.

[40]  J. Joannopoulos,et al.  Photonic crystals: putting a new twist on light , 1997, Nature.

[41]  Steven G. Johnson,et al.  Linear waveguides in photonic-crystal slabs , 2000 .

[42]  P. Fauchet,et al.  Nanoscale microcavity sensor for single particle detection. , 2007, Optics letters.

[43]  A. Di Falco,et al.  Slotted photonic crystal cavities with integrated microfluidics for biosensing applications. , 2011, Biosensors & bioelectronics.

[44]  G. Whitesides.  The origins and the future of microfluidics , 2006, Nature.

[45]  O. Levi,et al.  Sensitivity enhancement in photonic crystal slab biosensors. , 2010, Optics express.

[46]  Paul J Hergenrother,et al.  A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. , 2008, ACS chemical biology.

[47]  Brian T. Cunningham,et al.  A label-free photonic crystal biosensor imaging method for detection of cancer cell cytotoxicity and proliferation , 2007, Apoptosis.

[48]  Ye Fang,et al.  Resonant waveguide grating biosensor for living cell sensing. , 2006, Biophysical journal.

[49]  Thommey P. Thomas,et al.  Real-time biomolecular binding detection using a sensitive photonic crystal biosensor. , 2010, Analytical chemistry.

[50]  Brian T. Cunningham,et al.  Label-free imaging of cancer cells using photonic crystal biosensors and application to cytotoxicity screening of a natural compound library , 2008 .

[51]  Steven G. Johnson,et al.  Guided modes in photonic crystal slabs , 1999 .

[52]  Sanja Zlatanovic,et al.  Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration , 2009 .

[53]  K. Vahala.  Optical microcavities , 2003, Nature.

[54]  L. E. Regalado,et al.  Photonic crystal sensor based on surface waves for thin-film characterization. , 2002, Optics letters.

[55]  V. Konopsky,et al.  Photonic crystal surface waves for optical biosensing , 2007, 2011 International Workshop on Biophotonics.

[56]  J. Buriak,et al.  Specific detection of proteins using photonic crystal waveguides. , 2008, Optics express.

[57]  Guenter Gauglitz,et al.  Direct optical sensors: principles and selected applications , 2005, Analytical and bioanalytical chemistry.

[58]  J. Perkel,et al.  Who Needs Labels?: Macromolecular Interaction Sans Labels , 2009 .

[59]  Hyun-Yong Lee,et al.  Si-based omnidirectional reflector and transmission filter optimized at a wavelength of 1.55 μm , 2002 .

[60]  A. Tünnermann,et al.  Optical characterization of photonic crystal slabs using orthogonally oriented polarization filters. , 2008, Optics express.

[61]  Robert Magnusson,et al.  Resonant Photonic Biosensors with Polarization-Based Multiparametric Discrimination in Each Channel , 2011, Sensors.

[62]  Y. Jeng,et al.  Computer simulation of tension experiments of a thin film using an atomic model , 2002 .

[63]  P. Fauchet,et al.  Silicon photonic crystal nanocavity-coupled waveguides for error-corrected optical biosensing. , 2011, Biosensors & bioelectronics.

[64]  Martin Kristensen,et al.  Photonic-crystal waveguide biosensor. , 2007, Optics express.

[65]  G. Gauglitz,et al.  Label-free detection of biomolecular interaction by optical sensors , 2000, Fresenius' journal of analytical chemistry.

[66]  Yunbo Guo,et al.  Sensitive molecular binding assay using a photonic crystal structure in total internal reflection. , 2008, Optics express.

[67]  Lance G. Laing,et al.  Microplate-based, label-free detection of biomolecular interactions: applications in proteomics , 2006, Expert review of proteomics.

[68]  Charles J. Choi,et al.  A 96-well microplate incorporating a replica molded microfluidic network integrated with photonic crystal biosensors for high throughput kinetic biomolecular interaction analysis. , 2007, Lab on a chip.

[69]  David Erickson,et al.  A multiplexed optofluidic biomolecular sensor for low mass detection. , 2009, Lab on a chip.

[70]  John,et al.  Strong localization of photons in certain disordered dielectric superlattices. , 1987, Physical review letters.

[71]  Brian T. Cunningham,et al.  High sensitivity photonic crystal biosensor incorporating nanorod structures for enhanced surface area , 2008 .

[72]  J. Joannopoulos,et al.  High Extraction Efficiency of Spontaneous Emission from Slabs of Photonic Crystals , 1997 .

[73]  L. Frandsen,et al.  Photonic crystal nanostructures for optical biosensing applications. , 2009, Biosensors & bioelectronics.

[74]  Lars Hagedorn Frandsen,et al.  Silicon photonic crystal nanostructures for refractive index sensing , 2008 .

[75]  D. Psaltis,et al.  Nanofluidic tuning of photonic crystal circuits , 2006 .

[76]  Kazumi Wada,et al.  SiO2/TiO2 omnidirectional reflector and microcavity resonator via the sol-gel method , 1999 .

[77]  Ahmet Ali Yanik,et al.  Sub-wavelength Nanofluidics in Photonic Crystal Sensors References and Links , 2022 .

[78]  C.F.R. Mateus,et al.  VCSEL Optoelectronic Biosensor for Detection of Infectious Diseases , 2008, IEEE Photonics Technology Letters.

[79]  Uli Lemmer,et al.  Low-cost label-free biosensors using photonic crystals embedded between crossed polarizers. , 2010, Optics express.

[80]  J. Homola.  Present and future of surface plasmon resonance biosensors , 2003, Analytical and bioanalytical chemistry.

[81]  W. Robertson.  Experimental measurement of the effect of termination on surface electromagnetic waves in one-dimensional photonic bandgap arrays , 1999 .

[82]  J. S. Aitchison,et al.  A photonic nano-Bragg grating device integrated with microfluidic channels for bio-sensing applications , 2009 .