Synthesis and characterization of functionalized dihydropyrimidinones via one-pot isocyanide-based three-component reaction of N-formyl urea and dialkyl ACETYLENEDICARBOXYLATES

The reactive intermediate generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates was trapped by N-formyl urea to produce highly functionalized dihydropyrimidinones in fairly good yields. KEY WORDS : Alkyl isocyanides, Dialkyl acetylenedicarboxylate, N-Formyl urea, Three-component reaction, Dihydropyrimidinones Bull. Chem. Soc. Ethiop. 2017 , 31(2), 345-350.  DOI: http://dx.doi.org/10.4314/bcse.v31i2.16

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