Real‐time identification of liver cancers by using indocyanine green fluorescent imaging

We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compressed by the tumor.

[1]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[2]  Marc Ruel,et al.  A new and simplified method for coronary and graft imaging during CABG. , 2002, The heart surgery forum.

[3]  Y. Harihara,et al.  Management of new hepatic nodules detected by intraoperative ultrasonography during hepatic resection for hepatocellular carcinoma. , 1996, Surgery.

[4]  G. Kwant,et al.  Light-absorbing properties, stability, and spectral stabilization of indocyanine green. , 1976, Journal of applied physiology.

[5]  Y. Nakanuma,et al.  Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: a prospective study. , 1998, Gastroenterology.

[6]  D. Woodfield Hepatocellular carcinoma. , 1986, The New Zealand medical journal.

[7]  M. Makuuchi,et al.  Early hepatocellular carcinoma as an entity with a high rate of surgical cure , 1998, Hepatology.

[8]  A. Rahmouni,et al.  Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging , 1999, European Radiology.

[9]  Hiroshi Imamura,et al.  Intraoperative fluorescent cholangiography using indocyanine green: a biliary road map for safe surgery. , 2009, Journal of the American College of Surgeons.

[10]  T. Roskams,et al.  Early hepatocellular carcinoma and dysplastic nodules. , 2005, Seminars in liver disease.

[11]  Thomas Albrecht,et al.  Potential Value of Contrast-Enhanced Intraoperative Ultrasonography During Partial Hepatectomy for Metastases: An Essential Investigation Before Resection? , 2006, Annals of surgery.

[12]  M. Kadoya,et al.  Detection of Hepatic Metastases From Colorectal Carcinoma: Comparison of Histopathologic Features of Anatomically Resected Liver With Results of Preoperative Imaging , 2007, Journal of clinical gastroenterology.

[13]  I. Wanless,et al.  Terminology of nodular hepatocellular lesions , 1995 .

[14]  S. Kawasaki,et al.  Surgery for small liver cancers. , 1993, Seminars in surgical oncology.

[15]  B. Sigel,et al.  Accuracy of intraoperative ultrasonography in diagnosing liver metastasis from colorectal cancer: Evaluation with postoperative follow-up results , 1991, World Journal of Surgery.

[16]  D. Sahani,et al.  Intraoperative US in patients undergoing surgery for liver neoplasms: comparison with MR imaging. , 2004, Radiology.

[17]  K. Zhou,et al.  Mn-DPDP-enhanced 24-h delayed-scan MRI of hepatocellular carcinoma is correlated with histology , 2004, European Radiology.

[18]  A L Baert,et al.  Experimental liver cancers: Mn-DPDP-enhanced rims in MR-microangiographic-histologic correlation study. , 1993, Radiology.

[19]  D. Taggart,et al.  A comparison of transit-time flowmetry and intraoperative fluorescence imaging for assessing coronary artery bypass graft patency. , 2005, The Journal of thoracic and cardiovascular surgery.

[20]  Philip M. Long,et al.  Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling , 2005, Hepatology.

[21]  M. Makuuchi,et al.  Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma , 1990, The Lancet.

[22]  K. Hughes,et al.  Resection of hepatic metastases from colorectal carcinoma. The registry data. , 1994, Cancer treatment and research.

[23]  C. S. Davidson,et al.  Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. , 1960, The Journal of clinical investigation.

[24]  G. Belli,et al.  Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results , 2007, Surgical Endoscopy.

[25]  M. Makuuchi,et al.  Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma. , 2008, Gastroenterology.

[26]  Noriyuki Moriyama,et al.  Pathology of small hepatocellular carcinoma. A proposal for a new gross classification , 1987, Cancer.

[27]  M. Makuuchi,et al.  Ultrasonically guided subsegmentectomy. , 1985, Surgery, gynecology & obstetrics.

[28]  Myeong-Jin Kim,et al.  Mangafodipir trisodium‐enhanced MRI for the detection and characterization of focal hepatic lesions: Is delayed imaging useful? , 2006, Journal of magnetic resonance imaging : JMRI.

[29]  V. Mazzaferro,et al.  A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. , 2006, Gastroenterology.

[30]  M. Makuuchi,et al.  Detection of new tumors by intraoperative ultrasonography during repeated hepatic resections for hepatocellular carcinoma. , 2007, Archives of surgery.