Antimalarial activity of the 8-aminoquinolines.

[1]  A. Cowman,et al.  Chemotherapy and drug resistance in malaria. , 1990, International journal for parasitology.

[2]  D. C. Smith,et al.  Antimalarials. 16. Synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials. , 1989, Journal of medicinal chemistry.

[3]  F. Cox The shape of things to come , 1988, Nature.

[4]  F. Carroll,et al.  Peptide derivatives of primaquine as potential antimalarial agents. , 1988, Journal of medicinal chemistry.

[5]  Pedro Romero,et al.  A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria , 1988, Nature.

[6]  L. Miller Effective vaccine for humans? , 1988, Nature.

[7]  F. Cox Which way for malaria? , 1988, Nature.

[8]  J. Anders,et al.  Methemoglobin formation resulting from administration of candidate 8-aminoquinoline antiparasitic drugs in the dog. , 1988, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[9]  I. McGregor Malarial immunity: current trends and prospects. , 1987, Annals of tropical medicine and parasitology.

[10]  S. Hoffman,et al.  Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. , 1987, Science.

[11]  B. C. Morris,et al.  Methemoglobinogenic potential of primaquine and its mutagenicity in the Ames test. , 1987, Toxicology letters.

[12]  L. Bruce-Chwatt THE CHALLENGE OF MALARIA VACCINE: TRIALS AND TRIBULATIONS , 1987, The Lancet.

[13]  D. Warrell Pathophysiology of severe falciparum malaria in man , 1987, Parasitology.

[14]  F. Carroll,et al.  4,5-Disubstituted primaquine analogues as potential antimalarial agents. , 1986, Journal of Medicinal Chemistry.

[15]  K. Kulig,et al.  Drug- and Chemical-Induced Methaemoglobinaemia , 1986, Medical toxicology.

[16]  F. Carroll,et al.  Sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. , 1985, Journal of Medicinal Chemistry.

[17]  F. Carroll,et al.  4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. , 1985, Journal of Medicinal Chemistry.

[18]  C. Canfield,et al.  Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates. , 1985, Toxicology and applied pharmacology.

[19]  Judith L. Johnson,et al.  Synthesis of N4-(5-methoxy-7-benzofuranyl)-1,4-pentanediamine, an oxygen isostere of primaquine , 1985 .

[20]  P. Blumbergs,et al.  Antimalarials. 15. Side-chain analogues of 8-(4-amino-1-methylbutylamino)-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline , 1984 .

[21]  W. Peters,et al.  Antimalarial drugs. II. Current antimalarials and new drug developments. , 1984 .

[22]  L. H. Schmidt Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys , 1983, Antimicrobial Agents and Chemotherapy.

[23]  A. Schapira,et al.  MEFLOQUINE RESISTANCE OF FALCIPARUM MALARIA FROM TANZANIA ENHANCED BY TREATMENT , 1983, The Lancet.

[24]  H. Webster,et al.  TYPE II MEFLOQUINE RESISTANCE IN THAILAND , 1982, The Lancet.

[25]  R. Strube,et al.  Antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. A highly effective series of blood and tissue schizonticidal agents. , 1982, Journal of medicinal chemistry.

[26]  M. S. Khan,et al.  Antimalarials. 13. 5-Alkoxy analogues of 4-methylprimaquine. , 1982, Journal of medicinal chemistry.

[27]  L. H. Schmidt,et al.  Delineation of the Potentials of Primaquine as a Radical Curative and Prophylactic Drug , 1982, American Journal of Tropical Medicine and Hygiene.

[28]  L. H. Schmidt,et al.  Responses of Sporozoite-Induced and Trophozoite-Induced Infections to Standard Antimalarial Drugs , 1982, American Journal of Tropical Medicine and Hygiene.

[29]  R. Barlow Burger's Medicinal Chemistry, 4th edn, part III: edited by Manfred E. Wolff, John Wiley & Sons, 1981. £63.35 (xiv + 1354 pages) ISBN 0 471 01572 5 , 1982 .

[30]  C. Cheng,et al.  Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines. , 1981, Journal of Medicinal Chemistry.

[31]  J. Brown,et al.  New tissue schizontocidal antimalarial drugs. , 1981, Bulletin of the World Health Organization.

[32]  D. Evans,et al.  Urinary primaquine excretion and red cell methaemoglobin levels in man following a primaquine:chloroquine regimen. , 1980, British journal of clinical pharmacology.

[33]  H. Burghard,et al.  4,5-disubstituted primaquine analogs as potential antiprotozoan agents. , 1980, Journal of pharmaceutical sciences.

[34]  S. Archer,et al.  4-[(Aminoalkyl)amino]-1,2-dimethoxynaphthalenes as antimalarial agents. , 1980, Journal of Medicinal Chemistry.

[35]  F. Carroll,et al.  Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics. , 1980, Journal of medicinal chemistry.

[36]  K. Kinnamon,et al.  The development of a "high volume tissue schizonticidal drug screen" based upon mortality of mice inoculated with sporozoites of Plasmodium berghei. , 1979, American Journal of Tropical Medicine and Hygiene.

[37]  T. R. Sweeney,et al.  Primaquine analogues: derivatives of 4-amino-2-methoxyacridine. , 1979, Journal of Medicinal Chemistry.

[38]  Khan Ms,et al.  Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials. , 1979 .

[39]  F. Carroll,et al.  Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials. , 1979, Journal of Medicinal Chemistry.

[40]  C. Canfield,et al.  New experimental antimalarial drugs. , 1979, Advances in pharmacology and chemotherapy.

[41]  Shetty Rv,et al.  Synthesis of 2-substituted primaquine analogues as potential antimalarials. , 1978 .

[42]  Schmidt Lh Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). I. The courses of untreated infections. , 1978 .

[43]  F. Carroll,et al.  Resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid. , 1978, Journal of medicinal chemistry.

[44]  K. Tanabe,et al.  Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine. , 1978, Journal of Medicinal Chemistry.

[45]  R. Shetty,et al.  Synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials. , 1977, Journal of Medicinal Chemistry.

[46]  A. Markovac,et al.  Antimalarials. 10. Synthesis of 4-substituted primaquine analogues as candidate antimalarials. , 1977, Journal of Medicinal Chemistry.

[47]  K. Tanabe,et al.  Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine. , 1977, Journal of Medicinal Chemistry.

[48]  L. H. Schmidt,et al.  Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its d and l Isomers , 1977, Antimicrobial Agents and Chemotherapy.

[49]  K. Paul,et al.  5-Aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. , 1976, Journal of Pharmacy and Science.

[50]  F. Carroll,et al.  Reduced 8-aminoquinoline analogues as potential antimalarial agents. , 1976, Journal of medicinal chemistry.

[51]  P. G. Shute,et al.  Prepatent periods of a tropical strain of Plasmodium vivax after inoculations of tenfold dilutions of sporozoites. , 1976, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[52]  K. Kinnamon,et al.  Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. , 1976, American Journal of Tropical Medicine and Hygiene.

[53]  M. D. Young,et al.  Chemotherapy of Plasmodium vivax in Saimiri and Aotus models. , 1975, American Journal of Tropical Medicine and Hygiene.

[54]  H. Most,et al.  Rodent systems (Plasmodium berghei-Anopheles Stephensi) for screening compounds for potential causal prophylaxis. , 1975, The American journal of tropical medicine and hygiene.

[55]  C. Blanton,et al.  8-(Omega-aminoalkylamino)quinolines as potential prophylactic antimalarials. , 1974, Journal of medicinal chemistry.

[56]  E. Steck,et al.  The Chemotherapy of Protozoan Diseases , 1974 .

[57]  C. Canfield,et al.  Clinical testing of new antimalarial compounds. , 1974, Bulletin of the World Health Organization.

[58]  R. Pinder Malaria;: The design, use, and mode of action of chemotherapeutic agents, , 1975 .

[59]  R. Rozman Chemotherapy of malaria. , 1973, Annual Review of Pharmacology.

[60]  L. H. Schmidt Infections with Plasmodium falciparum and Plasmodium vivax in the owl monkey--model systems for basic biological and chemotherapeutic studies. , 1973, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[61]  A. R. Patel,et al.  Antimalarials. 7. Bis(trifluoromethyl)-.alpha.-(2-piperidyl)-4-quinolinemethanols , 1971 .

[62]  C. Canfield,et al.  Plasmodium vivax from Vietnam. Response to chloroquine-primaquine. , 1971, American Journal of Tropical Medicine and Hygiene.

[63]  R. Pinder Recent advances in the chemotherapy of malaria. , 1971, Progress in medicinal chemistry.

[64]  E. G. Moore,et al.  Synthesis of potential antimalarials: primaquine analogs. , 1970, Journal of pharmaceutical sciences.

[65]  W. Peters,et al.  The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages. , 1970, Annals of tropical medicine and parasitology.

[66]  G. Skrzypek,et al.  Malaria imported to the United States from Vietnam. Chemoprophylaxis evaluated in returning soldiers. , 1969, American Journal of Tropical Medicine and Hygiene.

[67]  R. Cohen,et al.  Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam. , 1968, The New England journal of medicine.

[68]  G. Skrzypek,et al.  The problem of vivax malaria in Vietnam returnees. II. Malaria chemoprophylaxis survey. , 1968, Military medicine.

[69]  O. Barrett The problem of vivax malaria in Vietnam returnees. , 1968, Military Medicine.

[70]  P. Russell,et al.  2,4,7-Triamino-6-ortho-substituted Arylpteridines. A New Series of Potent Antimalarial Agents. , 1967, Journal of medicinal chemistry.

[71]  L. Bruce-Chwatt Clinical trials of antimalarial drugs , 1967 .

[72]  R. Degowin,et al.  Effects of glucose-6-phosphate dehydrogenase deficiency upon the host and upon host-drug-malaria parasite interactions. , 1966, Military medicine.

[73]  L. H. Schmidt,et al.  Studies on the antimalarial activity of 1,2-dimethoxy-4-(bis-diethylaminoethyl)-amino-5-bromobenzene. , 1966, Bulletin of the World Health Organization.

[74]  M. Mahaley CHEMOTHERAPY AND IMMUNOLOGY OF BRAIN TUMORS. , 1965, Pennsylvania medical journal (1928).

[75]  W. K. Cowan,et al.  Primaquine and methemoglobin , 1964, Clinical pharmacology and therapeutics.

[76]  G. Coatney,et al.  Primaquine and quinocide as curative agents against sporozoite-induced Chesson strain vivax malaria. , 1962, Bulletin of the World Health Organization.

[77]  M. D. Young,et al.  Chloroquine resistance in Plasmodium falciparum. , 1961, The American journal of tropical medicine and hygiene.

[78]  G. Brewer,et al.  The concurrent weekly administration of chloroquine and primaquine for the prevention of Korean vivax malaria. , 1961, Bulletin of the World Health Organization.

[79]  J. Lanier,et al.  Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. , 1961, The American journal of tropical medicine and hygiene.

[80]  Lysenko Ay Use of quinocide in treatment and prophylaxis of vivax malaria. , 1960 .

[81]  R. C. Elderfield,et al.  Synthesis of Primaquine and Certain of its Analogs1 , 1955 .

[82]  Coatney Gr,et al.  Review of investigations in malaria chemotherapy; (U.S.A.) 1946 to 1954. , 1955 .

[83]  C. Archambeault Mass antimalarial therapy in veterans returning from Korea. , 1954, Journal of the American Medical Association.

[84]  L. S. Jackson,et al.  Korean vivax malaria. III. Curative effect and toxicity of primaquine in doses from 10 to 30 mg. daily. , 1953, The American journal of tropical medicine and hygiene.

[85]  G. Coatney,et al.  Korean vivax malaria. II. Curative treatment with pamaquine and primaquine. , 1953, The American journal of tropical medicine and hygiene.

[86]  G. Coatney,et al.  Studies in human malaria. XXXI. Comparison of primaquine, isopentaquine, SN-3883, and pamaquine as curative agents against Chesson strain vivax malaria. , 1953, The American journal of tropical medicine and hygiene.

[87]  C. Clayman,et al.  3. TOXICITY OF PRIMAQUINE IN CAUCASIANS , 1952 .

[88]  G. Coatney,et al.  Cure of Korean vivax malaria with pamaquine and primaquine. , 1952, Journal of the American Medical Association.

[89]  A. Alving,et al.  Mass therapy of subclinical vivax malaria with primaquine. , 1952, Journal of the American Medical Association.

[90]  C. Whorton,et al.  PENTAQUINE (SN-13,276), A THERAPEUTIC AGENT EFFECTIVE IN REDUCING THE RELAPSE RATE IN VIV AX MALARIA. , 1948, The Journal of clinical investigation.

[91]  C. Whorton,et al.  THE CLINICAL TRIAL OF EIGHTEEN ANALOGUES OF PAMAQUIN (PLASMOCHIN) IN VIV AX MALARIA (CHESSON STRAIN). , 1948, The Journal of clinical investigation.

[92]  C. Whorton,et al.  THE TOXICITY OF LARGE DOSES OF PENTAQUINE (SN-13,276), A NEW ANTIMALARIAL DRUG. , 1948, The Journal of clinical investigation.

[93]  R. Berliner,et al.  STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. VII. THE ANTIMALARIAL ACTIVITY OF PAMAQUINE. , 1948, The Journal of clinical investigation.

[94]  Elderfield Rc,et al.  Synthesis of certain 8-(5-alkylamino-1-methylpentylamino)-derivatives of quinoline. , 1947 .

[95]  Price Cc,et al.  Methylene and para-phenylene analogs of plasmocid. , 1946 .

[96]  H. Snyder,et al.  The Preparation of Unsymmetrical Diaryl Amines. 5-Phenylamino-6-methoxy-8-(3-diethylaminopropylamino)-quinoline1 , 1946 .

[97]  Loeb Rf Activity of a new antimalarial agent, pentaquine (SN 13,276). , 1946 .

[98]  Campbell Kn,et al.  Studies in the quinoline series; the preparation of some 8-(omega-alkylaminoalkylamino)-quinolines. , 1946 .

[99]  Drake Nl,et al.  Synthetic antimalarials; some derivatives of 8-aminoquinoline. , 1946 .

[100]  J. B. Wright,et al.  Alkylaminoalkyl Derivatives of 8-Aminoquinoline1 , 1946 .

[101]  S. L. Baird,et al.  Some N-Substituted Aminoquinolines1 , 1946 .

[102]  H. Gilman,et al.  5,6-Dimethoxy-8- (2,5-dimethyl- 1 -pyrryl)-quinoline1 , 1946 .

[103]  Baker Rh,et al.  The synthesis of some 8-aminoquinolines. , 1946 .

[104]  J. T. Maynard,et al.  Synthesis of 5-Substituted Derivatives of 6-Methoxy-8-aminoquinoline and of 5-Chloro-6-methoxyquinoline1 , 1946 .

[105]  R. T. Arnold,et al.  Synthesis of 6-phenoxy-8-(3'diethylaminopropylamino)-quinoline. , 1946, Journal of the American Chemical Society.

[106]  H. Snyder,et al.  Synthesis of 8-(3'diethylaminopropylamino)-6-methoxy-5-phenyl-quinoline. , 1946, Journal of the American Chemical Society.

[107]  H. Gilman,et al.  A sulfur analog of the plasmochin type: 8-(-diethylaminopropylamino)-6-quinolyl methyl sulfide. , 1946, Journal of the American Chemical Society.

[108]  L. Kissinger,et al.  5-Methyl-6-methoxy-8-(2'-diethylaminoethylamino)-quinoline. , 1946, Journal of the American Chemical Society.

[109]  K. Mislow,et al.  The synthesis of potential antimalarials; some 2-substituted 8-(3-diethylaminopropylamino)-quinolines. , 1946, Journal of the American Chemical Society.

[110]  C. Rondestvedt,et al.  Some derivatives of 8-aminoquinoline. , 1946, Journal of the American Chemical Society.

[111]  C. Hauser,et al.  Synthesis of antimalarials; synthesis of certain 8-aminoquinolines. , 1946, Journal of the American Chemical Society.

[112]  R. C. Elderfield,et al.  Synthesis of simple 2-phenyl-8-aminoquinoline derivatives. , 1946, Journal of the American Chemical Society.

[113]  L. Craig,et al.  A study of plasmochin and the occurrence of rearrangements in the preparation of certain plasmo chin analogs. , 1946, Journal of the American Chemical Society.

[114]  R. T. Arnold,et al.  8-(3-Diethylamino-2-hydroxypropylamino)-5,6-dimethyoxyquinoline and some of its homologs. , 1946, Journal of the American Chemical Society.

[115]  N. Drake,et al.  Synthetic antimalarials; 8-(5-isopropylaminoamylamino)-6-methoxyquinoline (SW-13,276) and some related compounds. , 1946, Journal of the American Chemical Society.

[116]  H. Feldman,et al.  Pamaquine naphthoate as a prophylactic for malarial infections. , 1946, Federation proceedings.

[117]  Fairley Nh Chemotherpeutic suppression and prophylaxis in Malaria. An experimental investigation undertaken by medical research teams in Australia , 1945 .

[118]  O. J. Magidson,et al.  Acridin‐Verbindungen und ihre Antimalaria‐Wirkung (I. Mitteil.) , 1936 .

[119]  O. J. Magidson,et al.  Die Derivate des 8‐Aminochinolins als Antimalariapräparate. Mitteilung IV: Verbindungen mit langen Ketten in 8‐Stellung , 1935 .

[120]  P. Tate,et al.  The Action of Synthetic Quinoline Compounds on Avian Malaria , 1933, Parasitology.

[121]  O. J. Magidson,et al.  Die Derivate des 8‐Aminochinolins als Antimalariapräparate. Mitteilung I. Die Wirkung von Alkyl in Stellung 6 auf chemotherapeutische Eigenschaften , 1933 .

[122]  S. P. James,et al.  Some general results of a study of induced malaria in England , 1931 .

[123]  A. W. Baldwin CCCXCIX.—Attempts to find new anti-malarials. Part III. Some substituted aminoalkylaminoquinolines , 2022 .

[124]  J. A. Sinton,et al.  Studies in Malaria, with Special Reference to Treatment. Part IX. Plasmoquine in the Treatment of Malaria. , 1928 .