Genetic detection of lymph node micrometastases in patients with colorectal cancer

Undetected micrometastases represent the single most important cause of treatment failure in patients undergoing putatively curative resection for colorectal cancer because current staging techniques are unable to identify patients with minimal residual disease.

[1]  C. Moertel.  Chemotherapy for colorectal cancer. , 1994, The New England journal of medicine.

[2]  F M van den Berg,et al.  Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. , 1993, Cancer research.

[3]  M. Ogawa,et al.  Genetic diagnosis of lymph-node metastasis in colorectal cancer , 1995, The Lancet.

[4]  K. Mimori,et al.  Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction. , 1995, Cancer research.

[5]  T. Ravikumar,et al.  Differences in messenger RNA expression of carcinoembryonic antigen in surgical specimens of colorectal carcinoma. , 1992, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[6]  D. Reintgen,et al.  Detection of Submicroscopic Lymph Node Metastases with Polymerase Chain Reaction in Patients with Malignant Melanoma , 1994, Annals of surgery.

[7]  V. Alves,et al.  Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins , 1991, Diseases of the colon and rectum.

[8]  Shinzaburo Noguchi,et al.  The detection of breast carcinoma micrometastases in axillary lymph nodes by means of reverse transcriptase‐polymerase chain reaction , 1994, Cancer.

[9]  H. Rockette,et al.  Detection and significance of occult axillary node metastases in patients with invasive breast cancer , 1978, Cancer.

[10]  A. Deblasio,et al.  Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays. , 1994, Cancer research.

[11]  M. Toner,et al.  The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma , 1994, The Journal of pathology.

[12]  T. G. Parks,et al.  Prognostic factors in colorectal cancer , 1992, The British journal of surgery.

[13]  D. Gotley,et al.  Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer. , 1996, British Journal of Cancer.

[14]  S. Burchill,et al.  The molecular detection of circulating tumour cells. , 1995, British Journal of Cancer.

[15]  R. Moll,et al.  Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns , 1990, The Journal of cell biology.

[16]  Y. Nakamura,et al.  Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method. , 1994, Cancer research.

[17]  S. Cawthorn,et al.  Clearance technique for the detection of lymph nodes in colorectal cancer , 1986, The British journal of surgery.

[18]  N. Haboubi,et al.  The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal carcinoma. , 1992, Journal of the Royal Society of Medicine.

[19]  J. Greenson,et al.  Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long‐term survival , 1994, Cancer.

[20]  S. T. Traweek,et al.  Keratin gene expression in non-epithelial tissues. Detection with polymerase chain reaction. , 1993, The American journal of pathology.

[21]  R. Moll,et al.  Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. , 1992, The American journal of pathology.

[22]  S. Shousha,et al.  Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction. , 1994, Cancer research.