Late presentation of drug withdrawal symptoms in newborns.

Significant symptoms of neonatal drug abstinence first occurred at between 2 and 4 weeks of age in seven infants. Irritability and tremulousness were the major late symptoms, and seizures occurred in four of the seven infants. One infant in whom the syndrome was not recognized showed progression of symptoms and died at 3 weeks of age. Although patterns of maternal drug-taking varied, methadone hydrochloride was taken in all cases; in two women, urine test findings confirmed methadone to be the only drug of abuse. Fetal accumulation and delayed excretion of the drugs may account for delayed onset of symptoms. Physicians caring for such high-risk infants should recognize the potential seriousness of this problem.

[1]  M. Kreek,et al.  Methadone plasma level: sustained by a reservoir of drug in tissue. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[2]  W. Leblanc,et al.  Methadone withdrawal in newborn infants. , 1972, The Journal of pediatrics.

[3]  S. Yasunaga,et al.  Maternal barbiturate utilization and neonatal withdrawal symptomatology. , 1972, The Journal of pediatrics.

[4]  R. Harper,et al.  Observations on heroin and methadone withdrawal in the newborn. , 1971, Pediatrics.

[5]  D. Annunziato.  Neonatal addiction to methadone. , 1971, Pediatrics.

[6]  H. Isbell,et al.  The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome. , 1949, The American journal of psychiatry.