Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity

[1]  B. Wicksteed,et al.  The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression , 2022, Cell death & disease.

[2]  Hongyu Song,et al.  Liver knockout YAP gene improved insulin resistance induced hepatic fibrosis. , 2021, The Journal of endocrinology.

[3]  H. El‐Serag,et al.  Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention , 2020, Nature Reviews Gastroenterology & Hepatology.

[4]  R. Vadigepalli,et al.  INTEGRATED MULTI-OMICS REVEALS GLUCOSE USE REPROGRAMMING AND IDENTIFIES A NOVEL HEXOKINASE IN ALCOHOLIC HEPATITIS. , 2020, Gastroenterology.

[5]  Bowen Shi,et al.  HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway , 2020, Cancer cell international.

[6]  P. Kaldis,et al.  Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division , 2020, Hepatology International.

[7]  G. Gores,et al.  The Hippo Pathway and YAP Signaling: Emerging Concepts in Regulation, Signaling, and Experimental Targeting Strategies with Implications for Hepatobiliary Malignancies. , 2020, Gene expression.

[8]  F. Beguinot,et al.  Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes , 2020, Frontiers in Physiology.

[9]  M. Filipuzzi,et al.  Cooperation Between MYC and β‐Catenin in Liver Tumorigenesis Requires Yap/Taz , 2020, Hepatology.

[10]  D. Sacks,et al.  Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells , 2019, Molecular biology of the cell.

[11]  T. Becker,et al.  Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[12]  Yuan Gao,et al.  A functional interaction between Hippo‐YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice , 2019, Journal of cellular and molecular medicine.

[13]  N. Chandel,et al.  Hepatic HKDC1 Expression Contributes to Liver Metabolism , 2018, Endocrinology.

[14]  A. Giaccia,et al.  Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. , 2018, Bio-protocol.

[15]  C. Beglinger,et al.  Insulin resistance causes inflammation in adipose tissue , 2018, The Journal of clinical investigation.

[16]  B. Layden,et al.  Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans , 2018, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[17]  F. Camargo,et al.  Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis. , 2017, Gastroenterology.

[18]  Timothy E. Reddy,et al.  HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. , 2016, Endocrinology.

[19]  Jian Wu,et al.  High expression of hexokinase domain containing 1 is associated with poor prognosis and aggressive phenotype in hepatocarcinoma. , 2016, Biochemical and biophysical research communications.

[20]  R. Kineman,et al.  Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice. , 2016, Endocrinology.

[21]  J. Locasale,et al.  The Warburg Effect: How Does it Benefit Cancer Cells? , 2016, Trends in biochemical sciences.

[22]  S. Koo,et al.  Regulation of glucose metabolism from a liver-centric perspective , 2016, Experimental & Molecular Medicine.

[23]  J. Christman,et al.  TLR4 Expression by Liver Resident Cells Mediates the Development of Glucose Intolerance and Insulin Resistance in Experimental Periodontitis , 2015, PloS one.

[24]  Hang He,et al.  Two-signal requirement for growth-promoting function of Yap in hepatocytes , 2015, eLife.

[25]  Christopher D. Brown,et al.  Coordinated Regulatory Variation Associated with Gestational Hyperglycemia Regulates Expression of the Novel Hexokinase HKDC1 , 2014, Nature Communications.

[26]  Neil Kaplowitz,et al.  Cell death and cell death responses in liver disease: mechanisms and clinical relevance. , 2014, Gastroenterology.

[27]  Gong-Hua Li,et al.  Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer , 2014, Bioinform..

[28]  L. Rui,et al.  Energy metabolism in the liver. , 2014, Comprehensive Physiology.

[29]  Weiwei Yang,et al.  Nuclear PKM2 regulates the Warburg effect , 2013, Cell cycle.

[30]  Timothy E. Reddy,et al.  Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies , 2013, Diabetes.

[31]  R. Loomba,et al.  Nonalcoholic fatty liver disease: Indications for liver biopsy and noninvasive biomarkers , 2012, Clinical liver disease.

[32]  L. Czupryniak,et al.  Major liver resection results in early exacerbation of insulin resistance, and may be a risk factor of developing overt diabetes in the future , 2012, Surgery Today.

[33]  M. Rossmeisl,et al.  Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control , 2012, International Journal of Obesity.

[34]  S. John,et al.  Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose , 2011, PloS one.

[35]  Sheng-Nan Lu,et al.  Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. , 2010, World journal of gastroenterology.

[36]  M. Jutila,et al.  Immunomodulatory Activity of Oenothein B Isolated from Epilobium angustifolium1 , 2009, The Journal of Immunology.

[37]  D. Irwin,et al.  Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene. , 2008, Comparative biochemistry and physiology. Part D, Genomics & proteomics.

[38]  Lianyue Yang,et al.  Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance. , 2004, World journal of gastroenterology.

[39]  S. R. Datta,et al.  BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis , 2003, Nature.

[40]  John Eric Wilson.  Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function , 2003, Journal of Experimental Biology.

[41]  S. Lenzen,et al.  Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells. , 1991, The Biochemical journal.

[42]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[43]  B. Spiegelman,et al.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. , 1993, Science.