The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events
暂无分享,去创建一个
I. Jatoi | A. Brenner | Yidong Chen | R. Vadlamudi | M. Rao | V. Kaklamani | S. Nirzhor | S. Viswanadhapalli | S. Timilsina | Subapriya Rajamanickam | Arhan D. Rao | Panneerdoss Subbarayalu | Nourhan Abdelfattah | Arhan Rao
[1] Fei-Ting Hsu,et al. Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer , 2021, Frontiers in Oncology.
[2] Yan Wang,et al. Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide , 2021, Journal of cellular and molecular medicine.
[3] V. Villegas,et al. Resistance and Overcoming Resistance in Breast Cancer , 2020, Breast cancer.
[4] Min Jung Kim,et al. Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway , 2020, Molecules.
[5] E. Nice,et al. Overcoming cancer therapeutic bottleneck by drug repurposing , 2020, Signal Transduction and Targeted Therapy.
[6] Q. Cheng,et al. PARP inhibitor resistance: the underlying mechanisms and clinical implications , 2020, Molecular Cancer.
[7] Hong Ma,et al. ERα, A Key Target for Cancer Therapy: A Review , 2020, OncoTargets and therapy.
[8] Fei-Ting Hsu,et al. Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF‐κB signalling participate in anti‐glioblastoma of imipramine , 2020, Journal of cellular and molecular medicine.
[9] T. Salo,et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells , 2020, Experimental & Molecular Medicine.
[10] Carlos L. Arteaga,et al. Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers , 2019, Breast Cancer Research.
[11] Jingping Yuan,et al. The effect of metformin on biomarkers and survivals for breast cancer‐ a systematic review and meta‐analysis of randomized clinical trials , 2019, Pharmacological research.
[12] Eric P. Winer,et al. Breast Cancer Treatment: A Review , 2019, JAMA.
[13] E. Winer,et al. CDK4/6 inhibition in breast cancer: current practice and future directions , 2018, Therapeutic advances in medical oncology.
[14] Fangkun Liu,et al. Repurposing psychiatric drugs as anti-cancer agents. , 2018, Cancer letters.
[15] P. Kristel,et al. RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[16] Derek LeRoith,et al. Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. , 2015, Physiological reviews.
[17] E. Plimack,et al. Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors , 2015, Investigational New Drugs.
[18] T. Hillhouse,et al. A brief history of the development of antidepressant drugs: from monoamines to glutamate. , 2015, Experimental and clinical psychopharmacology.
[19] M. Pollak. Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment , 2014, Nature Medicine.
[20] C. Caldon,et al. Estrogen Signaling and the DNA Damage Response in Hormone Dependent Breast Cancers , 2014, Front. Oncol..
[21] A. Butte,et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. , 2013, Cancer discovery.
[22] Jan Koster,et al. FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. , 2013, Cancer research.
[23] Shankar Balasubramanian,et al. Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells , 2013, Genome Biology.
[24] A. Pertsemlidis,et al. Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization , 2012, PloS one.
[25] Guangchuang Yu,et al. clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.
[26] J. Game,et al. Inhibiting homologous recombination for cancer therapy , 2012, Cancer biology & therapy.
[27] Jeremy M. Stark,et al. I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks. , 2012, Methods in molecular biology.
[28] Philip Machanick,et al. MEME-ChIP: motif analysis of large DNA datasets , 2011, Bioinform..
[29] W. Huber,et al. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets , 2011 .
[30] Brad T. Sherman,et al. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.
[31] A. Hsu,et al. Temsirolimus, an mTOR inhibitor for treatment of patients with advanced renal cell carcinoma. , 2008, Clinical journal of oncology nursing.
[32] Nihal Ahmad,et al. Dose translation from animal to human studies revisited , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[33] Mathieu Lupien,et al. CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. , 2008, Cancer research.
[34] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[35] Youping Deng,et al. GeneVenn - A web application for comparing gene lists using Venn diagrams , 2007, Bioinformation.
[36] T. Mak,et al. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal , 2006, The Journal of experimental medicine.
[37] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[38] R. Coombes,et al. FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines* , 2003, Journal of Biological Chemistry.
[39] M. Mandal,et al. Etk/Bmx Tyrosine Kinase Activates Pak1 and Regulates Tumorigenicity of Breast Cancer Cells* , 2001, The Journal of Biological Chemistry.
[40] S. Safe,et al. Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. , 1999, Molecular endocrinology.