Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.

[1]  A. Suzuki.  Cross-coupling reactions via organoboranes , 2002 .

[2]  Pasko Rakic,et al.  JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[3]  John P. Wolfe,et al.  Rational Development of Practical Catalysts for Aromatic Carbon−Nitrogen Bond Formation , 1998 .

[4]  Mark Ellisman,et al.  JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. , 2003, Developmental cell.

[5]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[6]  Akira Suzuki,et al.  Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998 , 1999 .

[7]  W. Delano.  The PyMOL Molecular Graphics System , 2002 .

[8]  Wolfgang H. B. Sauer,et al.  Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase. , 2004, Journal of medicinal chemistry.

[9]  J. Boehm,et al.  Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. , 1997, Bioorganic & medicinal chemistry.

[10]  P. Rakic,et al.  The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development , 1999, Neuron.

[11]  Norio Miyaura,et al.  Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds , 1995 .

[12]  J. Lisnock,et al.  The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity. , 2003, Chemistry & biology.

[13]  H. K. Sluss,et al.  Selective interaction of JNK protein kinase isoforms with transcription factors. , 1996, The EMBO journal.

[14]  S. Rault,et al.  Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles , 1999 .

[15]  G. Bemis,et al.  The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. , 1997, Chemistry & biology.

[16]  S. Buchwald,et al.  Scope and limitations of the Pd/BINAP-catalyzed amination of aryl bromides. , 2000, The Journal of organic chemistry.

[17]  C. Miller,et al.  p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system , 1995, Neuron.

[18]  P. Rakic,et al.  A critical role of neural-specific JNK3 for ischemic apoptosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  P. Caron,et al.  Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. , 1998, Structure.

[20]  S. Rault,et al.  Heck cross-coupling reaction of 3-iodoindazoles with methyl acrylate: a mild and flexible strategy to design 2-aza tryptamines , 2000 .

[21]  Sam-Yong Park,et al.  Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 , 2004, The EMBO journal.

[22]  P. Rakic,et al.  Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene , 1997, Nature.

[23]  S. Teague,et al.  Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity. , 2005, Bioorganic & medicinal chemistry letters.