CALOPOROSIDE, A NEW INHIBITOR OF PHOSPHOLIPASES C

Caloporus dichrous (Polyporaceae, Aphyllophorales) is a medium sized saprophytic polypore growing on wood or decaying fruiting bodies of other basidiomycetes, e.g. Inonotus obliquus2). It can be found in the northern parts of America, Europe or Asia. Frommycelial cultures of strains derived from collections in Germany, the USA, and South Korea, a compoundexhibiting weak antimicrobial activities was isolated. During a later screening, this compound was found to inhibit strongly phospholipase C isolated from pig brain. In the following we wish to describe the fermentation, isolation, structure elucidation and the biological activities of caloporoside, the first inhibitor of a phospholipase from a basidiomycete.