PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

[1]  Paul Cumming,et al.  Up‐regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain , 2006, The European journal of neuroscience.

[2]  J. Julien,et al.  Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.

[3]  S. DeKosky,et al.  Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain , 2005, The Journal of Neuroscience.

[4]  F. LaFerla,et al.  Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.

[5]  D. Wilcock,et al.  Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics , 2005, Journal of neuropathology and experimental neurology.

[6]  S. Karlsson,et al.  Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice , 2005, Neurobiology of Disease.

[7]  E. Masliah,et al.  Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease , 2005, Neurology.

[8]  M. Graeber,et al.  A Free Community Approach to Classifying Disease , 2004, PLoS medicine.

[9]  D. Wilcock,et al.  Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition , 2004, The Journal of Neuroscience.

[10]  T. Guilarte,et al.  Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. , 2004, Brain : a journal of neurology.

[11]  S. Wisniewski,et al.  PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. , 2004, The Journal of clinical investigation.

[12]  I. Ferrer,et al.  Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease , 2004, Brain pathology.

[13]  K. Davis,et al.  Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. , 2003, JAMA.

[14]  C. Holmes,et al.  Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report , 2003, Nature Medicine.

[15]  D. Schenk,et al.  The role of microglia in Alzheimer’s disease: friend or foe? , 2002, Neurobiology of Aging.

[16]  A. Hofman,et al.  Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. , 2001, The New England journal of medicine.

[17]  V. Nguyen,et al.  Immunological aspects of microglia: relevance to Alzheimer's disease , 2001, Neurochemistry International.

[18]  Roger N Gunn,et al.  In-vivo measurement of activated microglia in dementia , 2001, The Lancet.

[19]  G. Landreth,et al.  Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease , 2001 .

[20]  G. Landreth,et al.  Microglial interaction with beta-amyloid: implications for the pathogenesis of Alzheimer's disease. , 2001, Microscopy research and technique.

[21]  R B Banati,et al.  The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. , 2000, Brain : a journal of neurology.

[22]  R. Motter,et al.  Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.

[23]  T. Guilarte,et al.  Cellular and Subcellular Localization of Peripheral Benzodiazepine Receptors After Trimethyltin Neurotoxicity , 2000, Journal of neurochemistry.

[24]  R. Dempsey,et al.  Traumatic Brain Injury Leads to Increased Expression of Peripheral-Type Benzodiazepine Receptors, Neuronal Death, and Activation of Astrocytes and Microglia in Rat Thalamus , 2000, Experimental Neurology.

[25]  M. Mattson,et al.  Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. , 1999, Science.

[26]  R. Motter,et al.  Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.

[27]  D. Dickson Microglia in Alzheimer's disease and transgenic models. How close the fit? , 1999, The American journal of pathology.

[28]  B. Sommer,et al.  Association of microglia with amyloid plaques in brains of APP23 transgenic mice. , 1999, The American journal of pathology.

[29]  F. Rossi,et al.  beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. , 1999, The Journal of biological chemistry.

[30]  G. Baltuch,et al.  Microglia as mediators of inflammatory and degenerative diseases. , 1999, Annual review of neuroscience.

[31]  Alan C. Evans,et al.  PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis , 1997, Journal of neuroscience research.

[32]  D. Borchelt,et al.  Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins , 1997, Neuron.

[33]  Joseph S. Beckman,et al.  Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease , 1997, The Journal of Neuroscience.

[34]  W F Stewart,et al.  Risk of Alzheimer's disease and duration of NSAID use , 1997, Neurology.

[35]  R B Banati,et al.  PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microglia , 1997, Journal of neurocytology.

[36]  N L Foster,et al.  PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[37]  D. Schober,et al.  Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[38]  Richard S. J. Frackowiak,et al.  Macrophage and Astrocyte Populations in Relation to [3H]PK 11195 Binding in Rat Cerebral Cortex following a Local Ischaemic Lesion , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  P. Mcgeer,et al.  Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains , 1988, Neurology.

[40]  A. Lbert,et al.  Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease , 2022 .