Canine leptospirosis infections - clinical signs and outcome with different suspected Leptospira serogroups (42 cases).

OBJECTIVES The aim of the study was to investigate the presence of serum antibodies to different Leptospira serogroups in dogs with a clinical diagnosis of leptospirosis in southern Germany and to compare seroreactivity to different serogroups with history, clinical signs, laboratory findings and survival rate. METHODS In this study, the data of 42 dogs with the diagnosis of leptospirosis were evaluated retrospectively. Dogs were presented to the Small Animal Medicine Teaching Hospital (Medizinische Kleintierklinik) of the Ludwig Maximilians University Munich, Germany, between 1990 to 2003. RESULTS Reactivity to the serogroup grippotyphosa (13/42) was most frequently present, followed by reactivity to the serogroup saxkoebing (10/42). There was no difference in the clinical picture and the laboratory changes between dogs whose sera were reactive to different serogroups. CLINICAL SIGNIFICANCE Most of the dogs with leptospirosis in southern Germany had sera reacting to serogroups other than icterohaemorrhagiae and canicola, which are contained in the vaccine. Thus, currently available vaccines in Europe do not protect against the most common Leptospira organisms associated with clinical disease.

[1]  H. Erb,et al.  Influence of infecting serogroup on clinical features of leptospirosis in dogs. , 2006, Journal of veterinary internal medicine.

[2]  P. McDonough,et al.  Serologic responses of dogs given a commercial vaccine against Leptospira interrogans serovar pomona and Leptospira kirschneri serovar grippotyphosa. , 2005, American journal of veterinary research.

[3]  P. Levett.  Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  L. Cowgill,et al.  Treatment and outcome of dogs with leptospirosis: 36 cases (1990-1998). , 2000, Journal of the American Veterinary Medical Association.

[5]  P. Meyer,et al.  BEITRAG ZUR LEPTOSPIREN-SEROLOGIE DES HUNDES: VERGLEICH VON MAR- UND ELISA-ERGEBNISSEN , 1999 .

[6]  J. Nicolet,et al.  [An old disease with a new face: canine leptospirosis does not lose its relevance]. , 1999, Schweizer Archiv fur Tierheilkunde.

[7]  J. Randolph,et al.  Naturally acquired leptospirosis in 36 dogs: serological and clinicopathological features. , 1998, The Journal of small animal practice.

[8]  H L Smits,et al.  LEPTO dipstick, a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human sera , 1997, Journal of clinical microbiology.

[9]  K. Harkin,et al.  Canine leptospirosis in New Jersey and Michigan: 17 cases (1990-1995). , 1996, Journal of the American Animal Hospital Association.

[10]  E. Scanziani,et al.  Serological findings in cases of acute leptospirosis in the dog , 1994 .

[11]  I. S. Kim,et al.  Detection of leptospiral DNA by PCR , 1994, Journal of clinical microbiology.

[12]  J. Friedland,et al.  The Jarisch-Herxheimer reaction in leptospirosis: possible pathogenesis and review. , 1991, Reviews of infectious diseases.

[13]  Y. Yanagihara,et al.  Comparison of Protective Effects with Tetra‐Valent Glycolipid Antigens and Whole Cell‐Inactivated Vaccine in Experimental Infection of Leptospira , 1991, Microbiology and immunology.

[14]  G. Andre-Fontaine,et al.  New topics on leptospirosis. , 1990, Comparative immunology, microbiology and infectious diseases.

[15]  P. Meyer,et al.  [Leptospira antibody detection in dog serum in the years 1985 to 1988]. , 1990, Berliner und Munchener tierarztliche Wochenschrift.

[16]  T. V. D. van den Ingh,et al.  Clinical, pathological and serological features of spontaneous canine leptospirosis. An evaluation of the IgM- and IgG-specific ELISA. , 1986, Veterinary immunology and immunopathology.

[17]  J. Strandberg,et al.  Chronic active hepatitis in dogs associated with leptospires. , 1979, American journal of veterinary research.

[18]  C. Tsai,et al.  Leptospirosis in the Philippines: canine studies. , 1971, American journal of veterinary research.

[19]  M. Torten,et al.  The use of immunofluorescence in the diagnosis of human leptospirosis by a genus-specific antigen. , 1966, The Journal of infectious diseases.