Protein carbonyl groups as biomarkers of oxidative stress.

[1]  G. Mullin,et al.  Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease , 1996, Digestive Diseases and Sciences.

[2]  H. Ohshima,et al.  Increased Oxidative and Nitrative Stress in Human Stomach Associated with cagA+ Helicobacter pylori Infection and Inflammation , 2001, Digestive Diseases and Sciences.

[3]  I. Alafuzoff,et al.  Proteomic analysis of protein oxidation in Alzheimer's disease brain , 2002, Electrophoresis.

[4]  D. Butterfield,et al.  Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71 , 2002, Journal of neurochemistry.

[5]  D. Butterfield,et al.  Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. , 2002, Free radical biology & medicine.

[6]  M. Grisham,et al.  Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. , 2002, Free radical biology & medicine.

[7]  R. W. Gracy,et al.  Identification of oxidized plasma proteins in Alzheimer's disease. , 2002, Biochemical and biophysical research communications.

[8]  R. Levine Carbonyl modified proteins in cellular regulation, aging, and disease. , 2002, Free radical biology & medicine.

[9]  M. Beal Oxidatively modified proteins in aging and disease. , 2002, Free radical biology & medicine.

[10]  D. Giustarini,et al.  Methionine oxidation as a major cause of the functional impairment of oxidized actin. , 2002, Free radical biology & medicine.

[11]  J. Windsor,et al.  Proteolysis in severe sepsis is related to oxidation of plasma protein. , 2002, The European journal of surgery = Acta chirurgica.

[12]  Yau-Huei Wei,et al.  Increase in Oxidative Damage to Lipids and Proteins in Skeletal Muscle of Uremic Patients , 2002, Free radical research.

[13]  C. Winterbourn,et al.  Protein carbonyl measurement by ELISA. , 2002, Methods in molecular biology.

[14]  I. Young,et al.  Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[15]  D. Giustarini,et al.  Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment. , 2001, Free radical biology & medicine.

[16]  A. Mendelow,et al.  Comparison of protein carbonyl and antioxidant levels in brain tissue from intracerebral haemorrhage and control cases. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[17]  D. V. Van Wagoner,et al.  Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation , 2001, Circulation.

[18]  J. Himmelfarb,et al.  Albumin is the major plasma protein target of oxidant stress in uremia. , 2001, Kidney international.

[19]  R. W. Gracy,et al.  Identification of protein carbonyls after two‐dimensional electrophoresis , 2001, Proteomics.

[20]  F. Demayo,et al.  Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia. , 2001, American journal of respiratory and critical care medicine.

[21]  J. Warner,et al.  Oxidative Stress and Increased Type-IV Collagenase Levels in Bronchoalveolar Lavage Fluid from Newborn Babies , 2001, Pediatric Research.

[22]  A. Keshavarzian,et al.  iNOS upregulation mediates oxidant-induced disruption of F-actin and barrier of intestinal monolayers. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[23]  L. Chang,et al.  Oxidative damage to proteins and decrease of antioxidant capacity in patients with varicocele. , 2001, Free radical biology & medicine.

[24]  S. Powell,et al.  Actin is oxidized during myocardial ischemia. , 2001, Free radical biology & medicine.

[25]  D. Butterfield,et al.  Protein oxidation in the brain in Alzheimer's disease , 2001, Neuroscience.

[26]  S. Matalon,et al.  Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. , 2001, American journal of respiratory and critical care medicine.

[27]  A. Keshavarzian,et al.  OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability. , 2001, Free radical biology & medicine.

[28]  E. Steegers,et al.  Protein carbonyls in decidua and placenta of pre-eclamptic women as markers for oxidative stress. , 2001, Placenta.

[29]  L. T. McGrath,et al.  Breath isoprene during acute respiratory exacerbation in cystic fibrosis. , 2000, The European respiratory journal.

[30]  S. Salman,et al.  Oxidative protein damage in early stage Type 1 diabetic patients. , 2000, Diabetes research and clinical practice.

[31]  J. Himmelfarb,et al.  Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. , 2000, Kidney international.

[32]  E. Stadtman,et al.  Human studies related to protein oxidation: protein carbonyl content as a marker of damage. , 2000, Free radical research.

[33]  H R Griffiths,et al.  Antioxidants and protein oxidation. , 2000, Free radical research.

[34]  R. W. Gracy,et al.  Oxidized proteins in Alzheimer's plasma. , 2000, Biochemical and biophysical research communications.

[35]  F. Boscia,et al.  Protein oxidation and lens opacity in humans. , 2000, Investigative ophthalmology & visual science.

[36]  M. Wozniak,et al.  Protein carbonyl groups' content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis. , 2000, Free radical biology & medicine.

[37]  K. Uchida Role of reactive aldehyde in cardiovascular diseases. , 2000, Free radical biology & medicine.

[38]  A. Keshavarzian,et al.  Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor α in a human colonic cell line , 2000, Gut.

[39]  D. Butterfield,et al.  Oxidative Modification of Creatine Kinase BB in Alzheimer’s Disease Brain , 2000, Journal of neurochemistry.

[40]  W. Anderson,et al.  Increased oxidative damage to fibroblasts in skin with and without lesions in psoriasis. , 2000, The Journal of investigative dermatology.

[41]  C. Winterbourn,et al.  Elevated Protein Carbonyls and Lipid Peroxidation Products Correlating with Myeloperoxidase in Tracheal Aspirates from Premature Infants , 2000, Pediatric Research.

[42]  P. Zusterzeel,et al.  Plasma protein carbonyls in nonpregnant, healthy pregnant and preeclamptic women , 2000, Free radical research.

[43]  J. Windsor,et al.  Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients , 2000, Critical care medicine.

[44]  E. Shacter QUANTIFICATION AND SIGNIFICANCE OF PROTEIN OXIDATION IN BIOLOGICAL SAMPLES* , 2000, Drug metabolism reviews.

[45]  U. Çakatay,et al.  Oxidative protein damage in plasma of type 2 diabetic patients. , 2000, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[46]  D. Giustarini,et al.  The oxidation produced by hydrogen peroxide on Ca‐ATP‐G‐actin , 2000, Protein science : a publication of the Protein Society.

[47]  E. Shacter,et al.  Protein oxidative damage. , 2000, Methods in enzymology.

[48]  A. Keshavarzian,et al.  Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms. , 1999, The Journal of pharmacology and experimental therapeutics.

[49]  W. Kox,et al.  Oxidized proteins as a marker of oxidative stress during coronary heart surgery. , 1999, Free radical biology & medicine.

[50]  R. Colombo,et al.  The tert-butyl hydroperoxide-induced oxidation of actin Cys-374 is coupled with structural changes in distant regions of the protein. , 1999, Biochemistry.

[51]  A. Blackburn,et al.  Protein carbonyl formation on mucosal proteins in vitro and in dextran sulfate-induced colitis. , 1999, Free radical biology & medicine.

[52]  J. Fagan,et al.  Quantitation of oxidative damage to tissue proteins. , 1999, The international journal of biochemistry & cell biology.

[53]  G. Falkous,et al.  Quantification of protease activities in synovial fluid from rheumatoid and osteoarthritis cases: comparison with antioxidant and free radical damage markers. , 1999, Clinica chimica acta; international journal of clinical chemistry.

[54]  F. Kelly,et al.  Treatment of pulmonary exacerbations of cystic fibrosis leads to improved antioxidant status. , 1999, The European respiratory journal.

[55]  L. Bossaert,et al.  Oxidatively modified proteins in bronchoalveolar lavage fluid of patients with ARDS and patients at-risk for ARDS. , 1999, The European respiratory journal.

[56]  B. Halliwell,et al.  Measurement of protein carbonyls in human brain tissue. , 1999, Methods in enzymology.

[57]  C. Winterbourn,et al.  Protein carbonyl measurement by enzyme-linked immunosorbent assay. , 1999, Methods in enzymology.

[58]  A. Keshavarzian,et al.  Determination of protein carbonyl groups by immunoblotting. , 1999, Analytical biochemistry.

[59]  R. S. Sohal,et al.  Gel electrophoretic quantitation of protein carbonyls derivatized with tritiated sodium borohydride. , 1998, Analytical biochemistry.

[60]  J. Kleibeuker,et al.  Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease , 1998, The Journal of pathology.

[61]  R. S. Sohal,et al.  Identification of oxidized proteins based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing. , 1998, Analytical biochemistry.

[62]  M. Gussinyé,et al.  Oxidative Stress at Onset and in Early Stages of Type 1 Diabetes in Children and Adolescents , 1998, Diabetes Care.

[63]  R. Dean,et al.  Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque. , 1998, The Biochemical journal.

[64]  F. Boscia,et al.  Oxidative retinal products and ocular damages in diabetic patients. , 1998, Free radical biology & medicine.

[65]  J. Haycock,et al.  Differential protein oxidation in Duchenne and Becker muscular dystrophy , 1998, Neuroreport.

[66]  L. Johnson,et al.  Polyamines are required for microtubule formation during gastric mucosal healing. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[67]  H. Ishii,et al.  Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis , 1998, Gut.

[68]  E. Floor,et al.  Increased Protein Oxidation in Human Substantia Nigra Pars Compacta in Comparison with Basal Ganglia and Prefrontal Cortex Measured with an Improved Dinitrophenylhydrazine Assay , 1998, Journal of neurochemistry.

[69]  Robert H. Brown,et al.  Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis , 1997, Journal of neurochemistry.

[70]  E. Stadtman,et al.  Protein Oxidation in Aging, Disease, and Oxidative Stress* , 1997, The Journal of Biological Chemistry.

[71]  D. Butterfield,et al.  Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease , 1997, Journal of neurochemistry.

[72]  R. Dean,et al.  Biochemistry and pathology of radical-mediated protein oxidation. , 1997, The Biochemical journal.

[73]  E. Stadtman,et al.  Reactive oxygen-mediated protein oxidation in aging and disease. , 1997, Chemical research in toxicology.

[74]  G. Holmgren,et al.  Oxidative stress is found in amyloid deposits in systemic amyloidosis. , 1997, Biochemical and biophysical research communications.

[75]  H. Esterbauer,et al.  Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product. , 1997, Journal of lipid research.

[76]  F. Hsu,et al.  Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques* , 1997, The Journal of Biological Chemistry.

[77]  A. Kettle,et al.  Myeloperoxidase: a key regulator of neutrophil oxidant production. , 1997, Redox report : communications in free radical research.

[78]  A. Signorile,et al.  Oxidative protein damage in human diabetic eye: evidence of a retinal participation , 1997, European journal of clinical investigation.

[79]  J. G. Kim,et al.  Generation of a polyclonal antibody against lipid peroxide-modified proteins. , 1997, Free radical biology & medicine.

[80]  C. Winterbourn,et al.  Protein carbonyl measurement by a sensitive ELISA method. , 1997, Free radical biology & medicine.

[81]  L. Johnson,et al.  Relationship between polyamines, actin distribution, and gastric healing in rats. , 1996, The American journal of physiology.

[82]  J. Weidner,et al.  Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. , 1996, Gastroenterology.

[83]  B. Halliwell Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. , 1996, Free radical research.

[84]  T. Reinheckel,et al.  Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome* , 1996, The Journal of Biological Chemistry.

[85]  A. Nakamura,et al.  Analysis of protein carbonyls with 2,4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis. , 1996, Journal of biochemistry.

[86]  R. Stocker,et al.  Presence of hypochlorite-modified proteins in human atherosclerotic lesions. , 1996, The Journal of clinical investigation.

[87]  B. Halliwell,et al.  Oxidative damage and motor neurone disease difficulties in the measurement of protein carbonyls in human brain tissue. , 1996, Free radical research.

[88]  D. V. van Thiel,et al.  Association between reactive oxygen species and disease activity in chronic hepatitis C. , 1996, Free radical biology & medicine.

[89]  R. Colombo,et al.  H2O2-treated actin: assembly and polymer interactions with cross-linking proteins. , 1995, Biophysical journal.

[90]  R. S. Sohal,et al.  Differential oxidative damage to mitochondrial proteins during aging , 1995, Mechanisms of Ageing and Development.

[91]  D. Butterfield,et al.  Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation , 1995, Journal of neurochemistry.

[92]  S. Andersson,et al.  Early protein oxidation in the neonatal lung is related to development of chronic lung disease , 1995, Acta paediatrica.

[93]  J. Williams,et al.  Oxidative modification of fibrinogen inhibits thrombin-catalyzed clot formation. , 1995, Free radical biology & medicine.

[94]  T. Reinheckel,et al.  Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress , 1995, The Journal of Biological Chemistry.

[95]  E. Shacter,et al.  Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay. , 1994, Free radical biology & medicine.

[96]  J. Pepper,et al.  Sequential oxidative damage, and changes in iron-binding and iron-oxidising plasma antioxidants during cardiopulmonary bypass surgery. , 1994, Free radical research.

[97]  R. Levine,et al.  Oxidation of proteins in neonatal lungs. , 1994, Pediatrics.

[98]  T. Evans,et al.  Oxidative damage to plasma proteins in adult respiratory distress syndrome. , 1994, Free radical research.

[99]  E. Stadtman,et al.  Carbonyl assays for determination of oxidatively modified proteins. , 1994, Methods in enzymology.

[100]  L. Packer,et al.  Oxidative damage to proteins: spectrophotometric method for carbonyl assay. , 1994, Methods in enzymology.

[101]  Robert H. Brown,et al.  Superoxide Dismutase Activity, Oxidative Damage, and Mitochondrial Energy Metabolism in Familial and Sporadic Amyotrophic Lateral Sclerosis , 1993, Journal of neurochemistry.

[102]  R. J. Keller,et al.  Immunochemical detection of oxidized proteins. , 1993, Chemical research in toxicology.

[103]  W. Markesbery,et al.  Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[104]  E. Stadtman,et al.  Determination of carbonyl content in oxidatively modified proteins. , 1990, Methods in enzymology.

[105]  J L Witztum,et al.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.

[106]  R. Levine,et al.  Determination of carbonyl groups in oxidatively modified proteins by reduction with tritiated sodium borohydride. , 1989, Analytical biochemistry.

[107]  J L Witztum,et al.  Low density lipoprotein undergoes oxidative modification in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[108]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .