β-Endorphin and Schizophrenia

• To study the effects of β-endorphin in chronic schizophrenia, nine male patients participated in a double-blind crossover comparison of a single intravenous 20-mg injection of β-endorphin and saline. Bolus injection of β-endorphin from an albumincoated syringe produced markedly higher plasma concentrations than did slow intravenous infusion from a non$albumincoated syringe. β-endorphin intravenously injected in nine patients produced a statistically significant increase in serum prolactin levels. In one patient, both 10 mg of morphine sulfate and 20 mg of β-endorphin produced similar increases in the alpha power of the EEG. In eight patients, β-endorphin administration was associated with a statistically significant but not clinically obvious improvement in schizophrenic symptoms.

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