A single‐centre double‐blind trial of Trasylol therapy in primary acute pancreatitis

One hundred and sixty‐one consecutive patients with primary acute pancreatitis were admitted to a double‐blind trial of intravenous Trasylol therapy as a supplement to a standard regimen of conservative management. The patients were subdivided into younger (less than 60 years) and older patients (aged 60 years and over), and subjects in each group were randomly allocated on a double‐blind basis either to Trasylol therapy (starter 500 000 KIU and thereafter 200 000 q. i. d. for 5 days) or to placebo. There were 14 deaths (8.7 per cent), 7 in the Trasylol and 7 in the placebo group, and no significant difference was found in either the mortality or the major complications rate, either overall or within either age group.

[1]  N. Back.  DEATH FROM ACUTE PANCREATITIS , 1978, The Lancet.

[2]  B. F. Allam,et al.  Serum ionized calcium in acute pancreatitis , 1977, The British journal of surgery.

[3]  C. Imrie,et al.  Haematological abnormalities in acute pancreatitis. A prospective study. , 1977, Postgraduate medical journal.

[4]  C. Imrie,et al.  Arterial hypoxia in acute pancreatitis , 1977, The British journal of surgery.

[5]  B. Pasternack,et al.  Statistical methods for quantifying the severity of clinical acute pancreatitis. , 1977, The Journal of surgical research.

[6]  J. Ranson,et al.  Prognostic signs and nonoperative peritoneal lavage in acute pancreatitis. , 1976, Surgery, gynecology & obstetrics.

[7]  G. Weir,et al.  The hypocalcemia of acute pancreatitis. , 1975, Annals of internal medicine.

[8]  A. Whyte,et al.  A prospective study of acute pancreatitis , 1975, The British journal of surgery.

[9]  C. Rigby,et al.  A controlled trial of Trasylol in the treatment of acute pancreatitis , 1974, The British journal of surgery.

[10]  W. Lukash.  Complications of acute pancreatitis. Unusual sequelae in 100 cases. , 1967, Archives of surgery.

[11]  I. Marks,et al.  The management of severe acute pancreatitis. , 1967, Postgraduate medical journal.

[12]  R. Ammann.  Trasylol for acute pancreatitis , 1965, Deutsche medizinische Wochenschrift.

[13]  A. Skyring,et al.  Treatment of Acute Pancreatitis with Trasylol: Report of a Controlled Therapeutic Trial , 1965, British medical journal.

[14]  B. F. Allam,et al.  Hypocalcaemia of acute pancreatitis: the effect of hypoalbuminaemia. , 1976, Current medical research and opinion.

[15]  Dreiling Da,et al.  Trasylol revisited: the value of proteolytic inhibitors in the therapy of pancreatitis. , 1976 .

[16]  A. Greenstein,et al.  Trasylol revisited: the value of proteolytic inhibitors in the therapy of pancreatitis. , 1976, The Mount Sinai journal of medicine, New York.

[17]  L. Blumgart,et al.  Acute pancreatitis: a prospective study on some factors in mortality. , 1975, Bulletin de la Societe internationale de chirurgie.

[18]  K. Jordal,et al.  Prophylactic and curative action of Trasylol in pancreatitis. A double-blind trial. , 1969, Scandinavian journal of gastroenterology.