MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition

[1]  K. Knudsen,et al.  Beyond DNA repair: DNA-PK function in cancer. , 2014, Cancer discovery.

[2]  Yifeng Zhou,et al.  A Newfound Association between MDC1 Functional Polymorphism and Lung Cancer Risk in Chinese , 2014, PloS one.

[3]  K. Flatten,et al.  Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression* , 2014, The Journal of Biological Chemistry.

[4]  Q. Ji,et al.  Development of Serous Ovarian Cancer is Associated with the Expression of Homologous Recombination Pathway Proteins , 2014, Pathology & Oncology Research.

[5]  David Piwnica-Worms,et al.  Contribution of p53 to metastasis. , 2014, Cancer discovery.

[6]  Y. Song,et al.  Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma , 2014, BioMed research international.

[7]  H. Lieberman,et al.  DNA Damage Response Genes and the Development of Cancer Metastasis , 2014, Radiation research.

[8]  M. Masutani,et al.  Poly(ADP-ribosyl)ation in carcinogenesis. , 2013, Molecular aspects of medicine.

[9]  B. Blagoev,et al.  JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1–mediated chromatin response to DNA breaks , 2013, Nature Structural &Molecular Biology.

[10]  W. Foulkes,et al.  In Brief: BRCA1 and BRCA2 , 2013, The Journal of pathology.

[11]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[12]  R. Huang,et al.  Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer. , 2012, Current drug targets.

[13]  Nicola J. Curtin,et al.  DNA repair dysregulation from cancer driver to therapeutic target , 2012, Nature Reviews Cancer.

[14]  Peter Bouwman,et al.  The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance , 2012, Nature Reviews Cancer.

[15]  Fangzhou Song,et al.  NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer , 2011, Molecular and Cellular Biochemistry.

[16]  Benjamin J. Raphael,et al.  Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.

[17]  D. Armstrong,et al.  Recent progress in the diagnosis and treatment of ovarian cancer , 2011, CA: a cancer journal for clinicians.

[18]  Michel Salzet,et al.  Epithelial-mesenchymal transition in ovarian cancer. , 2010, Cancer letters.

[19]  Fangzhou Song,et al.  Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells , 2010, Molecular and Cellular Biochemistry.

[20]  M. Stucki,et al.  MDC1: The art of keeping things in focus , 2010, Chromosoma.

[21]  M. Goldberg,et al.  The cellular response to DNA damage: A focus on MDC1 and its interacting proteins , 2010, Nucleus.

[22]  P. Yaswen,et al.  A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells , 2009, PloS one.

[23]  J. Nesland,et al.  DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours , 2007, Oncogene.

[24]  A. Nakagawara,et al.  NFBD1/MDC1 Associates with p53 and Regulates Its Function at the Crossroad between Cell Survival and Death in Response to DNA Damage* , 2007, Journal of Biological Chemistry.

[25]  F. Alt,et al.  MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. , 2006, Molecular cell.

[26]  M. Yaffe,et al.  MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks , 2005, Cell.

[27]  S. Jackson,et al.  MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. , 2004, DNA repair.

[28]  N. Carter,et al.  A DNA damage checkpoint response in telomere-initiated senescence , 2003, Nature.

[29]  Junjie Chen,et al.  MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways , 2003, Nature.

[30]  Stephen J. Elledge,et al.  MDC1 is a mediator of the mammalian DNA damage checkpoint , 2003, Nature.

[31]  J. Bartek,et al.  MDC1 is required for the intra-S-phase DNA damage checkpoint , 2003, Nature.

[32]  M. King,et al.  BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. , 2001, Human molecular genetics.