Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine.

[1]  Kangdong Liu,et al.  Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC , 2023, Oncogenesis.

[2]  I. McKeague,et al.  Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: A review of the literature and description of a study protocol for a register-based cohort study , 2023, Reproductive toxicology.

[3]  L. S. Mathias,et al.  Placental model as an important tool to study maternal-fetal interface. , 2022, Reproductive toxicology.

[4]  S. LaPlante,et al.  Jumping from Fragment to Drug via Smart Scaffolds , 2022, ChemMedChem.

[5]  F. Staud,et al.  Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives , 2021, Pharmaceutics.

[6]  V. Préat,et al.  An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers. , 2021, Advanced drug delivery reviews.

[7]  O. Diav-Citrin,et al.  Pregnancy outcome after first trimester exposure to vortioxetine: A case series , 2021, Birth Defects Research.

[8]  Hong Wang,et al.  Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway , 2020, FEBS open bio.

[9]  Heungsoo Shin,et al.  Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine , 2020, Advanced healthcare materials.

[10]  E. Stelzer,et al.  E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity , 2018, Biology Open.

[11]  F. Tarazi,et al.  Vortioxetine: a novel antidepressant for the treatment of major depressive disorder , 2018, Expert opinion on drug discovery.

[12]  Håvard G. Frøysa,et al.  Effects of a complex mixture of persistent organic pollutants (POPs) on steroidogenesis in H295R cells under 10 μM forskolin stimulation - results from a pilot study , 2018 .

[13]  J. Qin,et al.  Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection. , 2018, ACS biomaterials science & engineering.

[14]  P. Wick,et al.  An advanced human in vitro co-culture model for translocation studies across the placental barrier , 2018, Scientific Reports.

[15]  T. Druley,et al.  RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts , 2018, Scientific Reports.

[16]  C. Bundgaard,et al.  Acute effects of vortioxetine and duloxetine on resting-state functional connectivity in the awake rat , 2018, Neuropharmacology.

[17]  A. Pastore,et al.  Vortioxetine exerts anti‐inflammatory and immunomodulatory effects on human monocytes/macrophages , 2018, British journal of pharmacology.

[18]  O. Karaman,et al.  Determination of minimum serum concentration to develop scaffold free micro-tissue , 2017 .

[19]  G. Nomikos,et al.  Vortioxetine: Clinical Pharmacokinetics and Drug Interactions , 2017, Clinical Pharmacokinetics.

[20]  P. Celada,et al.  Can we increase speed and efficacy of antidepressant treatments? Part I: General aspects and monoamine-based strategies , 2017, European Neuropsychopharmacology.

[21]  M. Richardson,et al.  Beyond organoids: In vitro vasculogenesis and angiogenesis using cells from mammals and zebrafish. , 2017, Reproductive toxicology.

[22]  A. Nishimura,et al.  Pharmacokinetics, Safety, and Tolerability of Vortioxetine Following Single‐ and Multiple‐Dose Administration in Healthy Japanese Adults , 2017, Clinical pharmacology in drug development.

[23]  C. Vaillancourt,et al.  Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. , 2017, Biochimie.

[24]  K. Newell,et al.  The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders , 2017, Neuroscience & Biobehavioral Reviews.

[25]  P. Ertl,et al.  A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines , 2017, Scientific Reports.

[26]  Patrick Caron,et al.  Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit , 2017, Molecular and Cellular Endocrinology.

[27]  Peter Wick,et al.  A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment. , 2016, Nanoscale.

[28]  Marc B. Stone,et al.  Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration’s Mini-Sentinel program , 2016, Archives of Women's Mental Health.

[29]  N. Müller,et al.  The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells , 2016, Archives of Gynecology and Obstetrics.

[30]  B. Schiøtt,et al.  Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter. , 2015, ACS chemical neuroscience.

[31]  Diane Hoffman-Kim,et al.  Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies. , 2015, Tissue engineering. Part C, Methods.

[32]  Anubhav Tripathi,et al.  Bio-Pick, Place, and Perfuse: A New Instrument for Three-Dimensional Tissue Engineering. , 2015, Tissue engineering. Part C, Methods.

[33]  Julie A. Murphy,et al.  Vortioxetine for the Treatment of Depression , 2014, The Annals of pharmacotherapy.

[34]  C. Vaillancourt,et al.  A Unique Co-culture Model for Fundamental and Applied Studies of Human Fetoplacental Steroidogenesis and Interference by Environmental Chemicals , 2014, Environmental health perspectives.

[35]  A. Jaffa,et al.  In vitro simulation of placental transport: part I. Biological model of the placental barrier. , 2013, Placenta.

[36]  D Elad,et al.  In vitro simulation of placental transport: part II. Glucose transfer across the placental barrier model. , 2013, Placenta.

[37]  A. Tripathi,et al.  Quantification of the kinetics and extent of self-sorting in three dimensional spheroids. , 2012, Tissue engineering. Part C, Methods.

[38]  T. Klempan,et al.  Stimulation of serotonergic 5-HT2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells. , 2011, Placenta.

[39]  Songül Aktaş,et al.  Gebelikte Depresyon: Sıklık, Risk Faktörleri ve Tedavisi , 2011 .

[40]  B. Huppertz,et al.  The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins. , 2010, Reproduction.

[41]  S. Lecoeur,et al.  The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies , 2010, Drug Metabolism and Disposition.

[42]  Jesper B Nielsen,et al.  Placental transport and in vitro effects of Bisphenol A. , 2010, Reproductive toxicology.

[43]  L. Knudsen,et al.  Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[44]  Anthony P. Napolitano,et al.  Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels. , 2007, Tissue engineering.

[45]  S. J. Michael,et al.  Placenta and Trophoblast , 2005, Methods in Molecular Medicine™.

[46]  C. Lavigne,et al.  Expression of the 5-HT2A serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin. , 2005, Placenta.

[47]  M. de Nictolis,et al.  Expression of ZO-1 and occludin in normal human placenta and in hydatidiform moles. , 2001, Molecular human reproduction.

[48]  M. Millan,et al.  Inhibition of the constitutive activity of human 5‐HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635 , 1997, British journal of pharmacology.

[49]  V. Ganapathy,et al.  Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells. , 1996, Placenta.

[50]  O. Blaschuk,et al.  E-cadherin expression during the differentiation of human trophoblasts. , 1991, Development.

[51]  O. Cassmer HORMONE PRODUCTION OF THE ISOLATED HUMAN PLACENTA , 1959 .

[52]  P. Myllynen,et al.  Biomarkers of Toxicity in Human Placenta , 2019, Biomarkers in Toxicology.

[53]  D. Huh,et al.  Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier , 2018, Advanced healthcare materials.

[54]  A. Doğan,et al.  COMPARISON OF MICROTISSUE FORMING CAPACITY OF SH-SY5Y AND SK-N-AS CELL LINES , 2016 .