OECD GUIDELINE FOR THE TESTING OF CHEMICALS

1. The OECD Test Guideline Programme periodically reviews progress in test method development and refinement, both in terms of scientific advances and animal welfare, to determine whether existing Test Guidelines should be updated and whether new Guidelines should be developed. Toward that end, a new assay for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLNA) has been sufficiently validated and accepted to justify its adoption as a new Test Guideline (1)(2)(3). This is the second Guideline to be promulgated for assessing skin sensitisation potential of chemicals in animals. The other Guideline (406) utilises guinea pig tests, notably the guinea pig maximisation test and the Buehler test (4).

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