Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Purpose The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined. Results A total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes. Conclusion The macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.

[1]  J. J. Wang,et al.  Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia. , 1997, Ophthalmology.

[2]  T. Wong,et al.  Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography , 2015, Journal of ophthalmology.

[3]  Eun Suk Lee,et al.  Influence of Cataract on Time Domain and Spectral Domain Optical Coherence Tomography Retinal Nerve Fiber Layer Measurements , 2010, Journal of glaucoma.

[4]  Edem Tsikata,et al.  Patient characteristics associated with artifacts in Spectralis optical coherence tomography imaging of the retinal nerve fiber layer in glaucoma. , 2015, American journal of ophthalmology.

[5]  Sanjay Asrani,et al.  Artifacts in spectral-domain optical coherence tomography measurements in glaucoma. , 2014, JAMA ophthalmology.

[6]  Jean-Claude Mwanza,et al.  Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head. , 2012, Ophthalmology.

[7]  G. Spaeth,et al.  The disc damage likelihood scale: reproducibility of a new method of estimating the amount of optic nerve damage caused by glaucoma. , 2002, Transactions of the American Ophthalmological Society.

[8]  W. Feuer,et al.  Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma. , 2011, Investigative ophthalmology & visual science.

[9]  Glenn J Jaffe,et al.  Evaluation of artifacts associated with macular spectral-domain optical coherence tomography. , 2010, Ophthalmology.

[10]  Youngrok Lee,et al.  Macular and retinal nerve fiber layer thickness: which is more helpful in the diagnosis of glaucoma? , 2011, Investigative ophthalmology & visual science.

[11]  W. Feuer,et al.  Myopia Affects Retinal Nerve Fiber Layer Measurements as Determined by Optical Coherence Tomography , 2009, Journal of glaucoma.

[12]  Min-Su Kim,et al.  Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell Layer in the Epiretinal Membrane: The Repeatability Study of Optical Coherence Tomography. , 2015, Investigative ophthalmology & visual science.

[13]  Jean-Claude Mwanza,et al.  Diagnostic performance of optical coherence tomography ganglion cell--inner plexiform layer thickness measurements in early glaucoma. , 2014, Ophthalmology.

[14]  Hiroshi Ishikawa,et al.  Effect of corneal drying on optical coherence tomography. , 2006, Ophthalmology.

[15]  J. Caprioli,et al.  Macular ganglion cell/inner plexiform layer measurements by spectral domain optical coherence tomography for detection of early glaucoma and comparison to retinal nerve fiber layer measurements. , 2013, American journal of ophthalmology.

[16]  R. Weinreb,et al.  Impact of age-related change of retinal nerve fiber layer and macular thicknesses on evaluation of glaucoma progression. , 2013, Ophthalmology.

[17]  Douglas R. Anderson,et al.  Clinical Decisions In Glaucoma , 1993 .

[18]  M. Riazi-esfahani,et al.  Optical Coherence Tomographic Findings in Highly Myopic Eyes , 2010, Journal of ophthalmic & vision research.

[19]  J. Renard,et al.  Reproducibility of macular ganglion cell–inner plexiform layer thickness measurement with cirrus HD-OCT in normal, hypertensive and glaucomatous eyes , 2013, British Journal of Ophthalmology.

[20]  Dong Myung Kim,et al.  Glaucoma detection ability of ganglion cell-inner plexiform layer thickness by spectral-domain optical coherence tomography in high myopia. , 2013, Investigative ophthalmology & visual science.

[21]  Hiroshi Ishikawa,et al.  Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography (SD-OCT) macular scans , 2012, British Journal of Ophthalmology.

[22]  A. Galor,et al.  Glaucoma therapy and ocular surface disease: current literature and recommendations , 2013, Current opinion in ophthalmology.