Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment.

[1]  M. Asadi,et al.  LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer , 2021, BioFactors.

[2]  A. Aref,et al.  Crosstalk between non-coding RNAs expression profile, drug resistance and immune response in breast cancer. , 2021, Pharmacological research.

[3]  Michael R Hamblin,et al.  Targeting the metabolism of cancer stem cells by energy disruptor molecules. , 2021, Critical reviews in oncology/hematology.

[4]  Michael R Hamblin,et al.  Development of neoantigens: from identification in cancer cells to application in cancer vaccines , 2021, Expert review of vaccines.

[5]  Kai Song,et al.  Signaling pathways governing breast cancer stem cells behavior , 2021, Stem cell research & therapy.

[6]  W. Shi,et al.  RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss , 2021, Cell Regeneration.

[7]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[8]  Michael R Hamblin,et al.  Approaches for the integration of big data in translational medicine: single‐cell and computational methods , 2021, Annals of the New York Academy of Sciences.

[9]  Nasim Ebrahimi,et al.  Analysis of polymorphic markers located in the HEXA gene region associated with Tay-Sachs disease , 2020 .

[10]  E. Tagliabue,et al.  Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness , 2020, International journal of molecular sciences.

[11]  Faying Xu,et al.  Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities , 2020, Molecular cancer.

[12]  Brock A. Humphries,et al.  Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses , 2020, Cells.

[13]  H. Teimori,et al.  Enhanced recombinant C-terminal domain of gli2 gene expression can improve wound healing through promoting cdc25b and N-Myc genes expression , 2020 .

[14]  B. Negahdari,et al.  Oncolytic virotherapy: Challenges and solutions. , 2020, Current problems in cancer.

[15]  Yoshimasa Tanaka,et al.  New Advances in Canonical Wnt/β-Catenin Signaling in Cancer , 2020, Cancer management and research.

[16]  L. Xiang,et al.  Taxotere-induced WNT16 Expression in Carcinoma-Associated Fibroblasts Might Associate with Progression and Chemoresistance of Breast Cancer. , 2020, Annals of clinical and laboratory science.

[17]  R. van Amerongen,et al.  Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence , 2020, Frontiers in Cell and Developmental Biology.

[18]  Lei Wei,et al.  BMX activates Wnt/β-catenin signaling pathway to promote cell proliferation and migration in breast cancer , 2019, Breast Cancer.

[19]  Neil Vasan,et al.  A view on drug resistance in cancer , 2019, Nature.

[20]  S. Sebti,et al.  A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors , 2019, Targeted Oncology.

[21]  Yuhong Xu,et al.  The Delivery of a Wnt Pathway Inhibitor Toward CSCs Requires Stable Liposome Encapsulation and Delayed Drug Release in Tumor Tissues. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[22]  Mamie Yu,et al.  Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility , 2019, Cell.

[23]  G. Hortobagyi,et al.  Current Landscape of Immunotherapy in Breast Cancer: A Review. , 2019, JAMA oncology.

[24]  Rachel E. Brewer,et al.  CD24 signalling through macrophage Siglec-10 is a new target for cancer immunotherapy , 2019, Nature.

[25]  A. Nikonova,et al.  Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer , 2019, Breast Cancer Research and Treatment.

[26]  F. Bertucci,et al.  Genomic characterization of metastatic breast cancers , 2019, Nature.

[27]  Maria Anna Rapsomaniki,et al.  A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer , 2019, Cell.

[28]  Yong Teng,et al.  Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges , 2019, Cells.

[29]  R. Cardiff,et al.  The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer. , 2019, Cancer research.

[30]  S. Lelièvre,et al.  Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling , 2019, Cancers.

[31]  Xue-Feng Li,et al.  Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2 , 2019, Journal of Experimental & Clinical Cancer Research.

[32]  M. Iorio,et al.  WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer , 2019, Oncogene.

[33]  P. Aspenström.  Activated Rho GTPases in Cancer—The Beginning of a New Paradigm , 2018, International journal of molecular sciences.

[34]  J. Pollard,et al.  Targeting macrophages: therapeutic approaches in cancer , 2018, Nature Reviews Drug Discovery.

[35]  E. Winer,et al.  Atezolizumab and Nab‐Paclitaxel in Advanced Triple‐Negative Breast Cancer , 2018, The New England journal of medicine.

[36]  Qian Zhang,et al.  Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling , 2018, Bioscience reports.

[37]  I. Jeremias,et al.  Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL. , 2018, Blood advances.

[38]  Yong Li,et al.  Cancer stem cell in breast cancer therapeutic resistance. , 2018, Cancer treatment reviews.

[39]  Collins Otieno Nyongesa,et al.  Chemotherapeutic resistance: a nano-mechanical point of view , 2018, Biological chemistry.

[40]  T. Fujiwara,et al.  Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment , 2018, Clinical Cancer Research.

[41]  Y. Drew,et al.  First-in-human phase 1 study of the PARP/tankyrase inhibitor 2X-121 (E7449) as monotherapy in patients with advanced solid tumors and validation of a novel drug response predictor (DRP) mRNA biomarker. , 2018 .

[42]  M. Hung,et al.  STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion , 2018, Nature Communications.

[43]  A. Tannapfel,et al.  A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity. , 2018, Cancer research.

[44]  C. A. Fraga,et al.  ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells , 2017, Scientific Reports.

[45]  M. Katoh.  Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review) , 2017, International journal of oncology.

[46]  John D Lambris,et al.  Complement in cancer: untangling an intricate relationship , 2017, Nature Reviews Immunology.

[47]  G. Hu,et al.  Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1 , 2017, Nature Cell Biology.

[48]  J. Chernoff,et al.  Suppression of RAC1-driven malignant melanoma by Group A PAK inhibitors , 2017, Oncogene.

[49]  K. O'Byrne,et al.  Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC , 2017, Oncotarget.

[50]  K. Pollok,et al.  Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer , 2017, npj Breast Cancer.

[51]  John B. Wallingford,et al.  Planar cell polarity in development and disease , 2017, Nature Reviews Molecular Cell Biology.

[52]  B. Leyland-Jones,et al.  RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers , 2016, Oncotarget.

[53]  Qi-cong Luo,et al.  Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway , 2016, Oncogene.

[54]  S. Batra,et al.  RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment , 2016, Oncogene.

[55]  D. Felsher,et al.  MYC regulates the antitumor immune response through CD47 and PD-L1 , 2016, Science.

[56]  Elisa de Stanchina,et al.  Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.

[57]  M. Soleimani,et al.  MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway , 2016, Tumor Biology.

[58]  M. Mlodzik,et al.  Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). , 2015, Annual review of cell and developmental biology.

[59]  T. Saibara,et al.  Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice , 2015, EBioMedicine.

[60]  Ede Migh,et al.  The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila , 2015, The Journal of Neuroscience.

[61]  J. Herman,et al.  Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth , 2015, Oncotarget.

[62]  Nhi Huynh,et al.  p21-activated kinase family: promising new drug targets , 2015 .

[63]  J. Jonkers,et al.  IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis , 2015, Nature.

[64]  Jianping Chen,et al.  Caveolin-1 mediates chemoresistance in breast cancer stem cells via β-catenin/ABCG2 signaling pathway. , 2014, Carcinogenesis.

[65]  K. Basler,et al.  Powerful Drosophila screens that paved the wingless pathway , 2014, Fly.

[66]  Y. Hozumi,et al.  RhoC Upregulation Is Correlated with Reduced E-cadherin in Human Breast Cancer Specimens After Chemotherapy and in Human Breast Cancer MCF-7 Cells , 2014, Hormones and Cancer.

[67]  H. Zhang,et al.  Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells , 2014, Breast Cancer Research.

[68]  T. Tan,et al.  FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway , 2014, Cell Death and Disease.

[69]  Michael Kahn,et al.  Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.

[70]  J. Pollard,et al.  Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. , 2014, Cancer research.

[71]  Zoe Backholer,et al.  First-in-human, first-in-class phase 1 study of a novel oral multi-AGC kinase inhibitor AT13148 in patients (pts) with advanced solid tumors. , 2014 .

[72]  David A. Brafman,et al.  The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells , 2014, Proceedings of the National Academy of Sciences.

[73]  Bruno M. Simões,et al.  Sox2 promotes tamoxifen resistance in breast cancer cells , 2013, EMBO molecular medicine.

[74]  A. Ridley.  RhoA, RhoB and RhoC have different roles in cancer cell migration , 2013, Journal of microscopy.

[75]  Luis E. Arias-Romero,et al.  Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. , 2013, Cancer research.

[76]  R. Kim,et al.  CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy , 2013, Breast Cancer Research and Treatment.

[77]  Jun Yao,et al.  Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. , 2013, Cancer cell.

[78]  Christof Niehrs,et al.  Secreted and transmembrane wnt inhibitors and activators. , 2013, Cold Spring Harbor perspectives in biology.

[79]  R. Hannoush,et al.  Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. , 2013, Cancer research.

[80]  C. Loddenkemper,et al.  WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer , 2013, EMBO molecular medicine.

[81]  C. Niehrs.  The complex world of WNT receptor signalling , 2012, Nature Reviews Molecular Cell Biology.

[82]  J. Vadgama,et al.  Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells , 2012, Molecular Cancer Research.

[83]  Ana Lluch,et al.  Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. , 2012, Cancer treatment reviews.

[84]  S. Weiss,et al.  Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression , 2012, Proceedings of the National Academy of Sciences.

[85]  E. Ruoslahti,et al.  TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells , 2012, Molecular Cancer Research.

[86]  S. Merajver,et al.  RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells , 2012, PloS one.

[87]  P. Jones,et al.  AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity , 2012, Clinical Cancer Research.

[88]  M. Fischer,et al.  Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors , 2012, Proceedings of the National Academy of Sciences.

[89]  Ying Yan,et al.  RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation , 2012, Breast Cancer Research.

[90]  G. Baldwin,et al.  P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth. , 2012, Cancer letters.

[91]  Drew M. Pardoll,et al.  The blockade of immune checkpoints in cancer immunotherapy , 2012, Nature Reviews Cancer.

[92]  Baiqu Huang,et al.  A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells , 2012, Oncogene.

[93]  Yong Zhao,et al.  Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. , 2011, Cancer letters.

[94]  K. Zhang,et al.  FZD7 has a critical role in cell proliferation in triple negative breast cancer , 2011, Oncogene.

[95]  Antara De,et al.  Wnt/Ca2+ signaling pathway: a brief overview. , 2011, Acta biochimica et biophysica Sinica.

[96]  Long-chang Jiang,et al.  [Effects of Cdc42 overexpression on the estrogen-enhanced multidrug resistance in breast cancer cells]. , 2011, Zhonghua zhong liu za zhi [Chinese journal of oncology].

[97]  D. Yin,et al.  CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes , 2011, Breast Cancer Research and Treatment.

[98]  I. Ellis,et al.  An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer , 2011, Breast Cancer Research and Treatment.

[99]  D. Kessler,et al.  Siamois and Twin are redundant and essential in formation of the Spemann organizer. , 2011, Developmental biology.

[100]  A. Harris,et al.  Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells , 2011, Proceedings of the National Academy of Sciences.

[101]  R. Kim,et al.  Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1) , 2011, Drug Metabolism and Disposition.

[102]  J. Cheng,et al.  Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling , 2011, Nature.

[103]  C. Vlaar,et al.  Novel inhibitors of Rac1 in metastatic breast cancer. , 2010, Puerto Rico health sciences journal.

[104]  R. Weinshilboum,et al.  Coprescription of tamoxifen and medications that inhibit CYP2D6. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[105]  Tatsushi Yoshida,et al.  Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein , 2010, Molecular Cancer Therapeutics.

[106]  Sijin Liu,et al.  Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. , 2009, Cancer research.

[107]  P. Casey,et al.  Rho GTPase activity modulates Wnt3a/beta-catenin signaling. , 2009, Cellular signalling.

[108]  R. Nusse,et al.  Towards an integrated view of Wnt signaling in development , 2009, Development.

[109]  Jie J. Zheng,et al.  Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. , 2009, Angewandte Chemie.

[110]  P. Greengard,et al.  Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner* , 2009, The Journal of Biological Chemistry.

[111]  R. Moon,et al.  CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. , 2008, The Journal of investigative dermatology.

[112]  T. Andersson,et al.  The Wnt-5a–Derived Hexapeptide Foxy-5 Inhibits Breast Cancer Metastasis In vivo by Targeting Cell Motility , 2008, Clinical Cancer Research.

[113]  B. Bapat,et al.  Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells , 2008, Molecular Cancer.

[114]  T. Giordano,et al.  Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast , 2008, Clinical Cancer Research.

[115]  David A. Williams,et al.  Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling , 2008, Cell.

[116]  R. Habas,et al.  SnapShot: Noncanonical Wnt Signaling Pathways , 2007, Cell.

[117]  A. Ruusala,et al.  Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases. , 2007, Experimental cell research.

[118]  J. Grosshans,et al.  Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. , 2007, Genes & development.

[119]  M. Cammer,et al.  Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. , 2007, Neoplasia.

[120]  Hans Clevers,et al.  Wnt/β-Catenin Signaling in Development and Disease , 2006, Cell.

[121]  R. Nusse,et al.  Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors* , 2006, Journal of Biological Chemistry.

[122]  W. Sterry,et al.  Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling , 2006, Molecular Cancer.

[123]  T. Andersson,et al.  Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells , 2006, Molecular and Cellular Biology.

[124]  Q. Tao,et al.  Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. , 2006, Carcinogenesis.

[125]  M. Katoh,et al.  WNT/PCP signaling pathway and human cancer (review). , 2005, Oncology reports.

[126]  M. Mlodzik,et al.  Planar cell polarization: an emerging model points in the right direction. , 2005, Annual review of cell and developmental biology.

[127]  Marek Mlodzik,et al.  Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding , 2005, Nature Cell Biology.

[128]  P. Cohen,et al.  The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. , 2005, The Biochemical journal.

[129]  A. Bejsovec,et al.  RacGap50C Negatively Regulates Wingless Pathway Activity During Drosophila Embryonic Development , 2005, Genetics.

[130]  P. Adler,et al.  Inturned Localizes to the Proximal Side of Wing Cells under the Instruction of Upstream Planar Polarity Proteins , 2004, Current Biology.

[131]  B. Bapat,et al.  Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of β-catenin and TCF/LEF-mediated transcriptional activation , 2004, Oncogene.

[132]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[133]  A. Wellstein,et al.  Altered Rho GTPase Signaling Pathways in Breast Cancer Cells , 2004, Breast Cancer Research and Treatment.

[134]  Xi He,et al.  A mechanism for Wnt coreceptor activation. , 2004, Molecular cell.

[135]  Louise R Howe,et al.  Wnt Signaling and Breast Cancer , 2004, Cancer biology & therapy.

[136]  S. Byers,et al.  Trans-repression of β-Catenin Activity by Nuclear Receptors* , 2003, Journal of Biological Chemistry.

[137]  A. Schinkel,et al.  Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. , 2003, Advanced drug delivery reviews.

[138]  Naoto Ueno,et al.  The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling , 2003, Molecular and Cellular Biology.

[139]  A. Minden,et al.  Rho regulates p21CIP1, cyclin D1, and checkpoint control in mammary epithelial cells , 2002, Oncogene.

[140]  S. Merajver,et al.  Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. , 2002, The American journal of pathology.

[141]  M. Streuli,et al.  Trp56 of Rac1 Specifies Interaction with a Subset of Guanine Nucleotide Exchange Factors* , 2001, The Journal of Biological Chemistry.

[142]  Amanda Y. Chan,et al.  Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways , 2001, Molecular medicine.

[143]  A. G. de Herreros,et al.  Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling , 2001, The Journal of cell biology.

[144]  A. Levine,et al.  Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. , 2001, Genes & development.

[145]  H Clevers,et al.  All Tcf HMG box transcription factors interact with Groucho-related co-repressors. , 2001, Nucleic acids research.

[146]  J. Herrington,et al.  Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. , 2000, Molecular endocrinology.

[147]  D. Strutt,et al.  Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye , 2000, Current Biology.

[148]  Eric S. Lander,et al.  Genomic analysis of metastasis reveals an essential role for RhoC , 2000, Nature.

[149]  C. Lagenaur,et al.  Role of CD47 as a marker of self on red blood cells. , 2000, Science.

[150]  E. Lengyel,et al.  Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b , 2000, Oncogene.

[151]  Y. Yarden,et al.  Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway , 2000, Molecular and Cellular Biology.

[152]  Zhi-Min Yuan,et al.  Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage* , 2000, The Journal of Biological Chemistry.

[153]  J. Groffen,et al.  Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[154]  C. Der,et al.  Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway* , 1999, The Journal of Biological Chemistry.

[155]  B. Kaina,et al.  Rho GTPases are over‐expressed in human tumors , 1999, International journal of cancer.

[156]  M. Boutros,et al.  Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling , 1998, Cell.

[157]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[158]  R. Moon,et al.  Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling , 1997, Nature.

[159]  P. Watkins,et al.  Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. , 1997, Molecular pharmacology.

[160]  F. Zindy,et al.  Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. , 1997, Genes & development.

[161]  M. Vijver,et al.  E‐cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. , 1995, The EMBO journal.

[162]  P. Crespo,et al.  The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway , 1995, Cell.

[163]  F. McCormick,et al.  An essential role for Rac in Ras transformation , 1995, Nature.

[164]  A. McMahon,et al.  Differential transformation of mammary epithelial cells by Wnt genes , 1994, Molecular and cellular biology.

[165]  Anne J. Ridley,et al.  The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.

[166]  S. Rodenhuis.  ras and human tumors. , 1992, Seminars in cancer biology.

[167]  A. Hall,et al.  Microinjection of recombinant p21rho induces rapid changes in cell morphology , 1990, The Journal of cell biology.

[168]  P. Lawrence,et al.  Phenocopies induced with antisense RNA identify the wingless gene , 1987, Cell.

[169]  Harold E. Varmus,et al.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.

[170]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[171]  Hideki Yamamoto,et al.  New insights into the mechanism of Wnt signaling pathway activation. , 2011, International review of cell and molecular biology.

[172]  Zheng Qi-chang.  Expression of Cdc42 in adriamycin-sensitivity and adriamycin-resistance MCF-7 human breast cancer cell line , 2010 .

[173]  D. Nie,et al.  Role of Rho GTPases in breast cancer. , 2008, Frontiers in bioscience : a journal and virtual library.

[174]  E. Schuetz,et al.  Transcriptional Control of Intestinal Cytochrome P-4503A by 1 (cid:1) ,25-Dihydroxy Vitamin D 3 , 2001 .

[175]  P. Casey,et al.  Protein prenylation: molecular mechanisms and functional consequences. , 1996, Annual review of biochemistry.

[176]  W. McGuire,et al.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. , 1987, Science.