Cyclic variation of ultrasound backscatter in normal myocardium is view dependent: clinical studies with a real-time backscatter imaging system.

Real-time ultrasound backscatter imaging is a new method of evaluating relative integrated backscatter in a clinically applicable manner. The potential clinical utility of real-time backscatter imaging of diseased tissue depends on recognition of normal variations in cyclic backscatter when measured from different echocardiographic image orientations. The view dependence of cyclic backscatter variation was studied in normal human volunteers. In twenty normal male subjects (mean age 28 +/- 5 years) cyclic variation in integrated backscatter (diastolic minus systolic backscatter) was assessed in multiple left ventricular regions with four standard two-dimensional echocardiographic views (parasternal long-axis and short-axis views, and apical two-chamber and four-chamber views). M-mode backscatter imaging was performed from the standard parasternal long-axis view. Cyclic variation in backscatter was present in the septum only when imaged from the parasternal long-axis view (2.7 +/- 3.1 [standard deviation] decibels [dB], p less than 0.01 for diastole versus systole). The posterior wall of the left ventricle demonstrated cyclic variation of integrated backscatter when imaged from both the parasternal long-axis (4.6 +/- 1.6 dB, p less than 0.01) and short-axis views (2.8 +/- 2.2 dB, p less than 0.01). Cyclic variation in integrated backscatter was not demonstrated in inferoseptal, septal, or lateral wall regions when imaged from the parasternal short-axis view. The apical views did not demonstrate cyclic variation in integrated backscatter in any of the segments studied.(ABSTRACT TRUNCATED AT 250 WORDS)

[1]  R L Popp,et al.  Influence of the orientation of myocardial fibers on echocardiographic images. , 1987, The American journal of cardiology.

[2]  J. G. Miller,et al.  Quantitative ultrasonic tissue characterization with real-time integrated backscatter imaging in normal human subjects and in patients with dilated cardiomyopathy. , 1987, Circulation.

[3]  J. G. Miller,et al.  Effects of myocardial contraction on ultrasonic backscatter before and after ischemia. , 1984, The American journal of physiology.

[4]  S. Wann,et al.  The Myocardial Signature: Absolute Backscatter, Cyclical Variation, Frequency Variation, and Statistics , 1986 .

[5]  L.J. Thomas,et al.  A Real-Time Integrated Backscatter Measurement System for Quantitative Cardiac Tissue Characterization , 1986, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  C. Jaffe,et al.  Physical factors influencing numerical echo‐amplitude data extracted from B‐scan ultrasound images , 1980, Journal of clinical ultrasound : JCU.

[7]  J. G. Miller,et al.  Changes in myocardial backscatter throughout the cardiac cycle. , 1983, Ultrasonic imaging.

[8]  J. Strohbehn,et al.  Two-Dimensional Ultrasonic Variation in Myocardium Throughout the Cardiac Cycle , 1986 .

[9]  J. G. Miller,et al.  A relationship between ultrasonic integrated backscatter and myocardial contractile function. , 1985, The Journal of clinical investigation.

[10]  J. G. Miller,et al.  Anisotropy of the ultrasonic backscatter of myocardial tissue: II. Measurements in vivo. , 1988, The Journal of the Acoustical Society of America.

[11]  J. G. Miller,et al.  Effects of Coronary Artery Occlusion and Reperfusion on Cardiac Cycle‐Dependent Variation of Myocardial Ultrasonic Backscatter , 1985, Circulation research.

[12]  J. G. Miller,et al.  Detection of remote myocardial infarction with quantitative real-time ultrasonic characterization. , 1988, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[13]  S. M. Collins,et al.  Variation of left ventricular myocardial gray level on two-dimensional echocardiograms as a result of cardiac contraction. , 1984, Circulation.

[14]  J. G. Miller,et al.  Anisotropy of the ultrasonic backscatter of myocardial tissue: I. Theory and measurements in vitro. , 1988, The Journal of the Acoustical Society of America.

[15]  J. Strohbehn,et al.  Two-dimensional ultrasonic tissue characterization: backscatter power, endocardial wall motion, and their phase relationship for normal, ischemic, and infarcted myocardium. , 1987, Circulation.