Pyrimethamine induces oxidative stress in Plasmodium yoelii 17XL-infected mice: a novel immunomodulatory mechanism of action for an old antimalarial drug?

[1]  A. Nzila,et al.  Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species. , 2009, Experimental parasitology.

[2]  V. Choubey,et al.  Antiplasmodial Activity of [(Aryl)arylsulfanylmethyl]Pyridine , 2007, Antimicrobial Agents and Chemotherapy.

[3]  J. L. Ventura-Gallegos,et al.  Immunomodulatory Role of Chloroquine and Pyrimethamine in Plasmodium yoelii 17XL Infected Mice , 2007, Scandinavian journal of immunology.

[4]  D. Fuchs,et al.  Crucial Role of Interferon-γ and Stimulated Macrophages in Cardiovascular Disease , 2006 .

[5]  L. Amaral,et al.  Review: The phenothiazinium chromophore and the evolution of antimalarial drugs , 2005, Tropical medicine & international health : TM & IH.

[6]  Zbynek Bozdech,et al.  Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome , 2004, Malaria Journal.

[7]  K. Becker,et al.  Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. , 2004, International journal for parasitology.

[8]  M. L. Ventura-Ayala,et al.  Early treatment during a primary malaria infection modifies the development of cross immunity , 2004, Parasite immunology.

[9]  S. Müller Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum , 2003, Redox report : communications in free radical research.

[10]  P. Delplace,et al.  Superoxide dismutase in Plasmodium: a current survey , 2003, Redox report : communications in free radical research.

[11]  I. Maclennan,et al.  Plasmodium chabaudi chabaudi Infection in Mice Induces Strong B Cell Responses and Striking But Temporary Changes in Splenic Cell Distribution1 , 2003, The Journal of Immunology.

[12]  R. Beyaert,et al.  Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations , 2002, British journal of haematology.

[13]  T. Onat,et al.  Antioxidant Enzyme Activities and Total Nitrite/ Nitrate Levels in the Collar Model. Effect of Nicardipine , 2000, Clinical chemistry and laboratory medicine.

[14]  D. Doolan,et al.  Immune effector mechanisms in malaria. , 1999, Current opinion in immunology.

[15]  N. Reiner,et al.  Activation of Phosphotyrosine Phosphatase Activity Attenuates Mitogen-Activated Protein Kinase Signaling and Inhibits c-FOS and Nitric Oxide Synthase Expression in Macrophages Infected with Leishmania donovani , 1999, Infection and Immunity.

[16]  Qureshi,et al.  Candida albicans suppresses nitric oxide (NO) production by interferon‐gamma (IFN‐γ) and lipopolysaccharide (LPS)‐stimulated murine peritoneal macrophages , 1999, Clinical and experimental immunology.

[17]  A. Senok,et al.  In vitro sensitivity of artemeter in Plasmodium falciparum-infected beta-thalassaemic trait erythrocytes , 1999, Parasitology.

[18]  D. Wolan,et al.  Antifungal Imidazoles Block Assembly of Inducible NO Synthase into an Active Dimer* , 1999, The Journal of Biological Chemistry.

[19]  C. Wanidworanun,et al.  Correlation of increased expression of intercellular adhesion molecule-1, but not high levels of tumor necrosis factor-alpha, with lethality of Plasmodium yoelii 17XL, a rodent model of cerebral malaria. , 1998, The American journal of tropical medicine and hygiene.

[20]  A. Sher,et al.  Paclitaxel (Taxol)-Induced Killing ofLeishmania major in Murine Macrophages , 1998, Infection and Immunity.

[21]  M. L. La Rosa,et al.  Doxycycline reduces mortality to lethal endotoxemia by reducing nitric oxide synthesis via an interleukin-10-independent mechanism. , 1998, The Journal of infectious diseases.

[22]  T. Triglia,et al.  Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[23]  P. Kremsner,et al.  Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artemether. , 1996, The Journal of antimicrobial chemotherapy.

[24]  W. Solbach,et al.  Early parasite containment is decisive for resistance to Leishmania major infection , 1995, European journal of immunology.

[25]  S. Edwards,et al.  Interferon-gamma enhances monocyte cytotoxicity via enhanced reactive oxygen intermediate production. Absence of an effect on macrophage cytotoxicity is due to failure to enhance reactive nitrogen intermediate production. , 1994, Immunology.

[26]  H. Ginsburg,et al.  The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems. , 1994, Parasite.

[27]  W. Wąsowicz,et al.  Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. , 1993, Clinical chemistry.

[28]  M. Good,et al.  The importance of T cell homing and the spleen in reaching a balance between malaria immunity and immunopathology: The moulding of immunity by early exposure to cross‐reactive organisms , 1992, Immunology and cell biology.

[29]  P. Sayles,et al.  Plasmodium yoelii: antibody response in resistant and susceptible mouse strains. , 1991, Experimental parasitology.

[30]  L. Miller,et al.  Cellular mechanisms in immunity to blood stage infection. , 1990, Immunology letters.

[31]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[32]  L. Weiss Mechanisms of splenic control of murine malaria: cellular reactions of the spleen in lethal (strain 17XL) Plasmodium yoelii malaria in BALB/c mice, and the consequences of pre-infective splenectomy. , 1989, The American journal of tropical medicine and hygiene.

[33]  T. Wellems,et al.  Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[34]  J. Eaton,et al.  Oxidant defense enzymes of Plasmodium falciparum. , 1988, Molecular and biochemical parasitology.

[35]  G. Glass,et al.  Decreased enzymic protection and increased sensitivity to oxidative damage in erythrocytes as a function of cell and donor aging. , 1984, The Biochemical journal.

[36]  J. Playfair,et al.  Killing of Plasmodium yoelii by enzyme-induced products of the oxidative burst , 1984, Infection and immunity.

[37]  D. Wyler Splenic functions in malaria. , 1983, Lymphology.

[38]  A. Glynn,et al.  Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice , 1974, Nature.

[39]  C. Nathan,et al.  Nitric oxide and macrophage function. , 1997, Annual review of immunology.

[40]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.

[41]  J. Playfair Lethal Plasmodium yoelii malaria: the role of macrophages in normal and immunized mice. , 1979, Bulletin of the World Health Organization.

[42]  Playfair Jh Lethal Plasmodium yoelii malaria: the role of macrophages in normal and immunized mice. , 1979 .