Atrophy in Sarcopenia Losartan Restores Skeletal Muscle Remodeling and Protects Against

, 82ra37 (2011); 3 Sci Transl Med , et al. Tyesha N. Burks Disuse Atrophy in Sarcopenia Losartan Restores Skeletal Muscle Remodeling and Protects Against Editor's Summary Losartan Comes of Age continue their street racing for many years to come. Go granny go. Administration (FDA) approved drug, may benefit sarcopenia patients and allow little old ladies everywhere to rapamycin (mTOR) pathways. These observations suggest that treatment with losartan, a Food and Drug for skeletal muscle homeostasis: the TGF-2 and insulin-like growth factor 1 (IGF-1)/Akt/mammalian target of further loss of muscle mass caused by immobilization; these effects were mediated via two signaling circuits critical sarcopenia. Losartan treatment improved muscle remodeling after injury and protected sarcopenic muscle from faulty repair in aged muscle. Burks et al. used losartan to antagonize TGF-2 signaling in an aged mouse model of Although the causes of sarcopenia are poorly understood, transforming growth factor 2 (TGF-2) may contribute to as a new drug candidate for treating sarcopenia. Burks et al. now identify losartan, an angiotensin II receptor antagonist commonly used to treat high blood pressure, muscle mass and strength called sarcopenia which can cause disability and predicts impending death in older adults. shortened stature is only one physical change associated with aging. Another, less jocular, transformation is loss of her Dodge around a southern California city. In popular culture, people link long life spans with being little ; yet, The Little Old Lady from Pasadena describes a diminutive woman of advanced years who aggressively drives