Organic Electronics at the Interface with Biology

The emergence of organic electronics represents one of the most dramatic technological developments of the past two decades. Perhaps the most important frontier of this field involves the interface with biology. The “soft” nature of organics offers better mechanical compatibility with tissue than traditional electronic materials, while their natural compatibility with mechanically flexible substrates suits the nonplanar form factors often required for implants. More importantly, the ability of organics to conduct ions in addition to electrons and holes opens up a new communication channel with biology. In this article, we consider a few examples that illustrate the coupling between organic electronics and biology and highlight new directions of research.

[1]  Paul M. Borsenberger,et al.  Organic photoreceptors for xerography , 1998 .

[2]  A. Turner,et al.  Ferrocene-mediated enzyme electrode for amperometric determination of glucose. , 1984, Analytical chemistry.

[3]  Gordon G Wallace,et al.  Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. , 2009, Biomaterials.

[4]  Elisabeth Smela,et al.  Conjugated Polymer Actuators , 2008 .

[5]  H. White,et al.  CHEMICAL DERIVATIZATION OF MICROELECTRODE ARRAYS BY OXIDATION OF PYRROLE AND N-METHYLPYRROLE: FABRICATION OF MOLECULE-BASED ELECTRONIC DEVICES. , 1984 .

[6]  Soyoun Jung,et al.  Drain Current Centric Modality: Instrumentation and Evaluation of ISFET for Monitoring Myocardial Ischemia Like Variations in pH and Potassium Ion Concentration , 2009, IEEE Sensors Journal.

[7]  A. Heeger,et al.  Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x , 1977 .

[8]  George G. Malliaras,et al.  Steady‐State and Transient Behavior of Organic Electrochemical Transistors , 2007 .

[9]  David Nilsson,et al.  An all-organic sensor-transistor based on a novel electrochemical transducer concept printed electrochemical sensors on paper , 2002 .

[10]  M. Abidian,et al.  Conducting‐Polymer Nanotubes for Controlled Drug Release , 2006, Advanced materials.

[11]  Adam Heller,et al.  Electrical Connection of Enzyme Redox Centers to Electrodes , 1992 .

[12]  George G. Malliaras,et al.  Enzymatic sensing with organic electrochemical transistors , 2008 .

[13]  Olle Inganäs,et al.  Polymer Hydrogel Microelectrodes for Neural Communication , 2002 .

[14]  Gordon G. Wallace,et al.  Integration of biocomponents with synthetic structures: use of conducting polymer polyelectrolyte composites , 1996, Smart Structures.

[15]  Kip A Ludwig,et al.  Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3,4‐ethylenedioxythiophene) Nanotubes , 2009, Advanced materials.

[16]  S. W. Thomas,et al.  Chemical sensors based on amplifying fluorescent conjugated polymers. , 2007, Chemical reviews.

[17]  A. Bonfiglio,et al.  Flexible Organic Thin-Film Transistors for pH Monitoring , 2009, IEEE Sensors Journal.

[18]  Loïc J Blum,et al.  Electro-chemiluminescent biosensing , 2008, Analytical and bioanalytical chemistry.

[19]  Luisa Torsi.  Organic thin-film transistors as analytical and bioanalytical sensors , 2006, Analytical and bioanalytical chemistry.

[20]  George G. Malliaras,et al.  An Organic Electronics Primer , 2005 .

[21]  David C. Martin,et al.  Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film , 2006, Journal of neural engineering.

[22]  T. Swager,et al.  Conjugated polymer-based chemical sensors. , 2000, Chemical reviews.

[23]  George G Malliaras,et al.  Chemical and biological sensors based on organic thin-film transistors , 2005, Analytical and bioanalytical chemistry.

[24]  G. Wegner,et al.  Simultaneous ionic and electronic conductivity in polymeric materials , 2005 .

[25]  C. Tang,et al.  Organic Electroluminescent Diodes , 1987 .

[26]  K. Mosbach,et al.  Molecularly imprinted polymers and their use in biomimetic sensors. , 2000, Chemical reviews.

[27]  Alwin M D Wan,et al.  Electrical control of cell density gradients on a conducting polymer surface. , 2009, Chemical communications.

[28]  Bernhard Lamprecht,et al.  Integrated organic electronic based optochemical sensors using polarization filters , 2008 .

[29]  George G Malliaras,et al.  Integration of a surface-directed microfluidic system with an organic electrochemical transistor array for multi-analyte biosensors. , 2009, Lab on a chip.

[30]  Ruth Shinar,et al.  Multianalyte sensor array based on an organic light emitting diode platform , 2008 .

[31]  A. Turner,et al.  Home blood glucose biosensors: a commercial perspective. , 2005, Biosensors & bioelectronics.

[32]  Xuhua Wang,et al.  Towards microalbuminuria determination on a disposable diagnostic microchip with integrated fluorescence detection based on thin-film organic light emitting diodes. , 2005, Lab on a chip.

[33]  N. Jaffrezic‐Renault,et al.  Trimethylamine biosensor based on pentacene enzymatic organic field effect transistor , 2009 .

[34]  Anthony Turner,et al.  Current trends in biosensor research and development , 1989 .

[35]  Edwin W H Jager,et al.  Electrochemical modulation of epithelia formation using conducting polymers. , 2009, Biomaterials.

[36]  David Nilsson,et al.  Active Control of Epithelial Cell‐Density Gradients Grown Along the Channel of an Organic Electrochemical Transistor , 2009, Advanced materials.

[37]  S. Erker,et al.  Rate Enhancement in Modified Polypyrrole Electrodes , 1986 .

[38]  Ruth Shinar,et al.  Glucose biosensors based on organic light-emitting devices structurally integrated with a luminescent sensing element , 2004 .

[39]  W. R. Salaneck,et al.  Electroluminescence in conjugated polymers , 1999, Nature.

[40]  Carmen Bartic,et al.  Field-effect detection of chemical species with hybrid organic/inorganic transistors , 2003 .

[41]  David C. Martin,et al.  Effect of Immobilized Nerve Growth Factor on Conductive Polymers: Electrical Properties and Cellular Response , 2007 .

[42]  C. Ohm,et al.  Stable insulating tethered bilayer lipid membranes , 2008, Biointerphases.

[43]  George G. Malliaras,et al.  All-Plastic Electrochemical Transistor for Glucose Sensing Using a Ferrocene Mediator , 2009, Sensors.

[44]  A. Gelperin,et al.  Integration and Response of Organic Electronics with Aqueous Microfluidics , 2002 .

[45]  R Langer,et al.  Stimulation of neurite outgrowth using an electrically conducting polymer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  M. Berggren,et al.  Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function. , 2009, Nature materials.

[47]  M. Berggren,et al.  Electronic control of Ca2+ signalling in neuronal cells using an organic electronic ion pump. , 2007, Nature materials.

[48]  Changcheng Zhu,et al.  A simple poly(3,4-ethylene dioxythiophene)/poly(styrene sulfonic acid) transistor for glucose sensing at neutral pH. , 2004, Chemical communications.

[49]  C. Gamrat,et al.  An Organic Nanoparticle Transistor Behaving as a Biological Spiking Synapse , 2009, 0907.2540.

[50]  Takao Someya,et al.  Organic Semiconductor Devices with Enhanced Field and Environmental Responses for Novel Applications , 2008 .

[51]  Erodible conducting polymers for potential biomedical applications. , 2002 .

[52]  L. C. Clark,et al.  ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY , 1962 .

[53]  D E Ingber,et al.  Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[54]  K. Shakesheff,et al.  Polymeric systems for controlled drug release. , 1999, Chemical reviews.

[55]  Edwin Jager,et al.  Nano-fiber scaffold electrodes based on PEDOT for cell stimulation , 2009 .

[56]  R. Forchheimer,et al.  Towards woven logic from organic electronic fibres. , 2007, Nature materials.

[57]  Christine E. Schmidt,et al.  Conducting polymers in biomedical engineering , 2007 .

[58]  Charles E. Swenberg,et al.  Electronic Processes in Organic Crystals and Polymers , 1999 .

[59]  W. Reichert.  Indwelling Neural Implants : Strategies for Contending with the In Vivo Environment , 2007 .

[60]  George G. Malliaras,et al.  Gating of an organic transistor through a bilayer lipid membrane with ion channels , 2006 .

[61]  Luisa Torsi,et al.  Multi-parameter gas sensors based on organic thin-film-transistors , 2000 .

[62]  G. Wallace,et al.  Conducting polymers for neural interfaces: challenges in developing an effective long-term implant. , 2008, Biomaterials.

[63]  Xinyan Tracy Cui,et al.  Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[64]  David C. Martin,et al.  Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells. , 2007, Biomaterials.

[65]  Annalisa Bonfiglio,et al.  Flexible, organic, ion-sensitive field-effect transistor , 2005 .

[66]  David C. Martin,et al.  Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. , 2004, Journal of biomedical materials research. Part A.