Early ultrasonographic diagnosis of placental mesenchymal dysplasia.

Placental mesenchymal dysplasia (PMD) is a rare pathology characterized by vascular anomalies, placentomegaly and grapelike vesicles resembling partial molar pregnancy. PMD is often associated with fetal growth restriction or intrauterine fetal demise. We report a case of an early diagnosis of PMD at 10 weeks' gestation, with a regular intrauterine growth and a fetal demise occurring at 31 week's gestation. The placenta showed aneurysmally dilated and tortuous vessels with luminal thrombosis. Even in presence of a regular fetal growth, a fetal demise may always occur, suggesting the option of an early heparin administration to reduce the risk of thrombosis of chorionic vessels.

[1]  A. Iwase,et al.  A case report of placental mesenchymal dysplasia with an increased VEGF-D expression. , 2012, Placenta.

[2]  C. Saccardi,et al.  Placental mesenchymal dysplasia: can early diagnosis ensure a good materno-foetal outcome? A case report , 2012, Archives of Gynecology and Obstetrics.

[3]  T. Shirogane,et al.  Placental mesenchymal dysplasia, a case of intrauterine sudden death of fetus with rupture of cirsoid periumbilical chorionic vessels , 2011, Diagnostic pathology.

[4]  E. Castro,et al.  Neither normal nor diseased placentas contain lymphatic vessels. , 2011, Placenta.

[5]  L. Groome,et al.  D2-40/podoplanin expression in the human placenta. , 2011, Placenta.

[6]  M. Sule,et al.  Placental mesenchymal dysplasia—can it be predicted prenatally? A case report , 2009, Prenatal diagnosis.

[7]  A. Heazell,et al.  A case of intrauterine growth restriction in association with placental mesenchymal dysplasia with abnormal placental lymphatic development. , 2009, Placenta.

[8]  K. Benirschke,et al.  Placental Mesenchymal Dysplasia Is Associated With High Rates of Intrauterine Growth Restriction and Fetal Demise , 2006 .

[9]  K. Benirschke,et al.  Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise: A report of 11 new cases and a review of the literature. , 2006, American journal of clinical pathology.

[10]  N. Sebire,et al.  Placental mesenchymal dysplasia associated with fetal aneuploidy , 2005, Prenatal diagnosis.

[11]  A. Sampson,et al.  Placental mesenchymal dysplasia: A report of four cases with differentiation from partial hydatidiform mole , 2003, The Australian & New Zealand journal of obstetrics & gynaecology.

[12]  A. Mitsuhashi,et al.  Placental mesenchymal dysplasia initially diagnosed as partial mole , 2003, Pathology international.

[13]  M. Nakayama,et al.  Suspected involvement of the X chromosome in placental mesenchymal dysplasia , 2002, Congenital anomalies.

[14]  N. Sebire,et al.  Pseudo‐partial moles: placental stem vessel hydrops and the association with Beckwith–Wiedemann syndrome and complete moles , 2001, Histopathology.

[15]  K. Nicolaides,et al.  Perinatal features associated with placental mesenchymal dysplasia. , 1997, Placenta.

[16]  Chih-ping Chen,et al.  Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia. , 1997, Human reproduction.

[17]  L. Sunde,et al.  Placental vascular malformation with mesenchymal hyperplasia and a localized chorioangioma. A rarity simulating partial mole. , 1994, Pathology, research and practice.

[18]  C. M. Sander.  Angiomatous malformation of placental chorionic stem vessels and pseudo-partial molar placentas: report of five cases. , 1993, Pediatric Pathology.

[19]  J. Lage.  Placentomegaly with massive hydrops of placental stem villi, diploid DNA content, and fetal omphaloceles: possible association with Beckwith-Wiedemann syndrome. , 1991, Human pathology.

[20]  J. Hustin,et al.  Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia. A new clinico-pathological entity? , 1991, Pathology, research and practice.