Multiple myeloma without a paraprotein. Report of a case with observations on chromosomal composition.

THE wide application of electrophoretic and immunologic techniques to the study of the paraimmunoglobulins in multiple myeloma has been of great value in the diagnosis and management of this disease. After thorough study, however, in a few patients, 1-3 clearly documented multiple myeloma is found in the complete absence of a paraprotein in either serum or urine. The purpose of this report is to present such a patient in whom a distinctly abnormal chromosome pattern was found. A variety of investigators 4-13 have studied the chromosomal compositions of both the bone marrow and the blood of myeloma patients. A heterogeneous group of chromosomal abnormalities have been observed in the majority of patients reported. 7-13 The studies on this patient are compared to those reported in the literature and the relationship of chromosome changes to the paraproteins explored. Report of a Case This 48-year-old retired Air Force officer was first admitted

[1]  J. Waldenstroem,et al.  THE OCCURRENCE OF BENIGN, ESSENTIAL MONOCLONAL (M TYPE), NON-MACROMOLECULAR HYPERGLOBULINEMIA AND ITS DIFFERENTIAL DIAGNOSIS. IV. STUDIES IN THE GAMMAPATHIES. , 2009 .

[2]  O. Forssman,et al.  A case of myeloma with flaming plasma cells but no significant M-compound in serum or urine. , 2009, Acta medica Scandinavica.

[3]  G. Riva,et al.  Chromosomal abnormalities in macroglobulinemia Waldenström: discordant findings in uniovular twins. , 2009, Acta medica Scandinavica. Supplementum.

[4]  J. Durant,et al.  Cytogenetic studies in multiple myeloma: a study of fourteen cases. , 1967, Cancer research.

[5]  W. C. Levin,et al.  Chromosomal aberrations common to three types of monoclonal gammopathies. , 1967, Blood.

[6]  J. Fahey,et al.  QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. , 1965, Journal of immunology.

[7]  F. Lewis,et al.  AN ABNORMAL CHROMOSOMAL PATTERN IN MYELOMATOSIS , 1963 .

[8]  M. Elves,et al.  Chromosomes and Serum Proteins: A Linked Abnormality , 1963, British medical journal.

[9]  C. Bottura.  CHROMOSOME ABNORMALITIES IN MULTIPLE MYELOMA. , 1963, Acta haematologica.

[10]  R. Crow,et al.  CHROMOSOMAL ABNORMALITIES IN MULTIPLE MYELOMA , 1963 .

[11]  G. Castoldi,et al.  Chromosomal imbalance in plasmacytoma. , 1963, Lancet.

[12]  G. Moore,et al.  The in Vitro Chromosome Constitution of Cells from Human Tumors , 1962 .

[13]  K. Benirschke,et al.  CHROMOSOMAL ABNORMALITIES IN WALDENSTRÖM'S MACROGLOBULINÆMIA , 1962 .

[14]  K. Patau.  CHROMOSOMAL ABNORMALITIES IN WALDENSTRÖM'S MACROGLOBULINÆMLA , 1961 .

[15]  A. Awa,et al.  Multiple Myeloma—An In Vitro Study , 1961, British Journal of Cancer.

[16]  P. Nowell,et al.  Chromosome preparations of leukocytes cultured from human peripheral blood. , 1960, Experimental cell research.

[17]  D. Gleason,et al.  The significance of urine electrophoresis in patients with multiple myeloma. , 1960, Archives of internal medicine.

[18]  A. Motulsky,et al.  Cryo- and macroglobulinemia; electrophoretic, ultracentrifugal and clinical studies. , 1956, The American journal of medicine.

[19]  E. Osserman,et al.  Abnormal serum and urine proteins in thirty five cases of multiple myeloma, as studied by filter paper electrophoresis. , 1955, The American journal of medicine.

[20]  J. Tjio,et al.  Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration. , 1962, Stain technology.

[21]  P. Grabar,et al.  The use of immunochemical methods in studies on proteins. , 1958, Advances in protein chemistry.