LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins

[1]  J. Armstrong,et al.  Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression , 2023, Nature Communications.

[2]  A. Strasser,et al.  BCL-2 protein family: attractive targets for cancer therapy , 2022, Apoptosis.

[3]  M. Mund,et al.  The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation , 2022, Molecular cell.

[4]  A. García-Sáez,et al.  Apoptosis regulation at the mitochondria membrane level. , 2021, Biochimica et biophysica acta. Biomembranes.

[5]  M. Mofrad,et al.  Molecular models of LINC complex assembly at the nuclear envelope. , 2021, Journal of cell science.

[6]  D. Andrews,et al.  Pharmacological Targeting of Executioner Proteins: Controlling Life and Death. , 2021, Journal of medicinal chemistry.

[7]  C. Borner,et al.  Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins , 2020, Cell Death Discovery.

[8]  R. Vallee,et al.  Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo , 2020, Current Biology.

[9]  H. Worman,et al.  The nuclear envelope: target and mediator of the apoptotic process , 2020, Cell Death Discovery.

[10]  Wei Wu,et al.  ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. , 2019, Developmental cell.

[11]  T. Moldoveanu,et al.  BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins. , 2019, Cold Spring Harbor perspectives in biology.

[12]  D. Hodzic,et al.  Chain reaction: LINC complexes and nuclear positioning , 2019, F1000Research.

[13]  Daniel A Starr,et al.  SUN/KASH interactions facilitate force transmission across the nuclear envelope , 2019, Nucleus.

[14]  G. Gillet,et al.  Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins , 2018, Front. Cell Dev. Biol..

[15]  S. Cory,et al.  The BCL-2 arbiters of apoptosis and their growing role as cancer targets , 2017, Cell Death and Differentiation.

[16]  G. Gundersen,et al.  Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning , 2017, Current Biology.

[17]  D. Green,et al.  MOMP, cell suicide as a BCL-2 family business , 2017, Cell Death and Differentiation.

[18]  A. Gross,et al.  Non-apoptotic functions of BCL-2 family proteins , 2017, Cell Death and Differentiation.

[19]  G. Charras,et al.  Fascin Regulates Nuclear Movement and Deformation in Migrating Cells , 2016, Developmental cell.

[20]  G. Ichim,et al.  A fate worse than death: apoptosis as an oncogenic process , 2016, Nature Reviews Cancer.

[21]  David L. Vaux,et al.  Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies , 2016, Nature Reviews Cancer.

[22]  Christopher A. Lemmon,et al.  Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension. , 2016, Biophysical journal.

[23]  D. Hodzic,et al.  A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I , 2015, Neurobiology of Disease.

[24]  G. Gundersen,et al.  Accessorizing and anchoring the LINC complex for multifunctionality , 2015, The Journal of cell biology.

[25]  G. Gundersen,et al.  Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts , 2015, Nucleus.

[26]  S. Frank,et al.  Differential retrotranslocation of mitochondrial Bax and Bak , 2015, The EMBO journal.

[27]  C. Borner,et al.  Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release , 2014, Nucleus.

[28]  I. Stagljar,et al.  FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement , 2014, Nature Cell Biology.

[29]  N. Duong,et al.  Nesprins: Tissue-Specific Expression of Epsilon and Other Short Isoforms , 2014, PloS one.

[30]  C. Borner,et al.  Non-canonical function of Bax in stress-induced nuclear protein redistribution , 2013, Cellular and Molecular Life Sciences.

[31]  Denis Wirtz,et al.  The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration , 2012, Scientific Reports.

[32]  D. Green,et al.  A unified model of mammalian BCL-2 protein family interactions at the mitochondria. , 2011, Molecular cell.

[33]  J. Martinou,et al.  Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. , 2011, Developmental cell.

[34]  Daniel A Starr KASH and SUN proteins , 2011, Current Biology.

[35]  C. Borner,et al.  Nuclear proteins acting on mitochondria. , 2011, Biochimica et biophysica acta.

[36]  Erin C. Vintinner,et al.  Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement , 2010, Science.

[37]  C. Borner,et al.  Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL , 2010, Cell Death and Differentiation.

[38]  G. Gundersen,et al.  Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins , 2009, Journal of Cell Science.

[39]  G. Dewson,et al.  Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis , 2009, Journal of Cell Science.

[40]  A. Noegel,et al.  Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin , 2008, Journal of Cell Science.

[41]  Juliet A. Ellis,et al.  Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. , 2007, Human molecular genetics.

[42]  Y. Benjamini,et al.  Adaptive linear step-up procedures that control the false discovery rate , 2006 .

[43]  C. Borner,et al.  Bak but not Bax is essential for Bcl-xS-induced apoptosis , 2005, Cell Death and Differentiation.

[44]  Juliet A. Ellis,et al.  Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle , 2005, Journal of Cell Science.

[45]  Juliet A. Ellis,et al.  Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. , 2001, Journal of cell science.

[46]  Y. Hsu,et al.  Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations* , 1998, The Journal of Biological Chemistry.