Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference

[1]  D. Swinkels,et al.  The metabolic syndrome and its traits as risk factors for subclinical atherosclerosis. , 2009, The Journal of clinical endocrinology and metabolism.

[2]  D. Swinkels,et al.  Brachial artery diameter is related to cardiovascular risk factors and intima‐media thickness , 2009, European journal of clinical investigation.

[3]  A. Bulmer,et al.  Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. , 2008, Atherosclerosis.

[4]  H. Schwertner,et al.  Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. , 2008, Atherosclerosis.

[5]  J. O’Connell,et al.  The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study. , 2008, American heart journal.

[6]  George Davey Smith,et al.  Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology , 2008, Statistics in medicine.

[7]  I. Kullo,et al.  Serum uric acid is associated with microvascular function in hypertensive individuals , 2007, Journal of Human Hypertension.

[8]  F. Hsu,et al.  Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults: The Cardiovascular Health Study , 2007, Circulation.

[9]  L. Bielak,et al.  Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults. , 2007, Clinical science.

[10]  S. Ryter,et al.  Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. , 2007, American journal of respiratory cell and molecular biology.

[11]  Florian Kronenberg,et al.  Association Between the UGT1A1*28 Allele, Bilirubin Levels, and Coronary Heart Disease in the Framingham Heart Study , 2006, Circulation.

[12]  R. Stocker.  Antioxidant activities of bile pigments. , 2004, Antioxidants & redox signaling.

[13]  S. Greenland.  Quantifying Biases in Causal Models: Classical Confounding vs Collider-Stratification Bias , 2003, Epidemiology.

[14]  M. Joyner,et al.  Aging and Forearm Postjunctional &agr;-Adrenergic Vasoconstriction in Healthy Men , 2002, Circulation.

[15]  K. Nicolaides,et al.  Flow‐mediated dilatation of the brachial artery in pregnancy at high altitude , 2002, BJOG : an international journal of obstetrics and gynaecology.

[16]  S. Reis,et al.  Large brachial artery diameter is associated with angiographic coronary artery disease in women. , 2002, American heart journal.

[17]  Z. Mareček,et al.  Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. , 2002, Atherosclerosis.

[18]  S. Cole,et al.  Fallibility in estimating direct effects. , 2002, International journal of epidemiology.

[19]  E. Benjamin,et al.  Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. , 2002, Journal of the American College of Cardiology.

[20]  M. Hernán,et al.  Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiology. , 2002, American journal of epidemiology.

[21]  E. Schouten,et al.  Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes. , 2001, International journal of epidemiology.

[22]  D. Levy,et al.  Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. , 2001, The American journal of cardiology.

[23]  O. Landt,et al.  Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects , 2000, Hepatology.

[24]  G. Plotnick,et al.  A comparison of brachial artery row‐mediated vasodilation using upper and lower arm arterial occlusion in subjects with and without coronary risk factors , 2000, Clinical cardiology.

[25]  H. Schwertner,et al.  Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease. , 2000, Atherosclerosis.

[26]  P. Valensi,et al.  Impairment of skin vasoconstrictive response to sympathetic activation in obese patients: influence of rheological disorders. , 2000, Metabolism: clinical and experimental.

[27]  E. Beutler,et al.  Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[28]  H. Schwertner.  Association of smoking and low serum bilirubin antioxidant concentrations. , 1998, Atherosclerosis.

[29]  M. Jensen-Urstad,et al.  Vascular function correlates with risk factors for cardiovascular disease in a healthy population of 35‐year‐old subjects , 1997, Journal of internal medicine.

[30]  S. Raja,et al.  alpha-Adrenoceptor mechanisms of thermoregulation during cold challenge in humans. , 1996, Clinical science.

[31]  B. Burchell,et al.  Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome , 1996, The Lancet.

[32]  D Lindhout,et al.  The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. , 1995, The New England journal of medicine.

[33]  G. Plotnick,et al.  Technical aspects of evaluating brachial artery vasodilatation using high-frequency ultrasound. , 1995, The American journal of physiology.

[34]  S. Greenland,et al.  Simulation study of confounder-selection strategies. , 1993, American journal of epidemiology.

[35]  P. Whelton,et al.  Vascular reactivity in young adults and cardiovascular disease. A prospective study. , 1992, Hypertension.

[36]  William J. Kostuk,et al.  Large Artery Function in Patients With Chronic Heart Failure: Studies of Brachial Artery Diameter and Hemodynamics , 1991, Circulation.

[37]  E. Simonson,et al.  Mortality and coronary heart disease among men studied for 23 years. , 1971, Archives of internal medicine.

[38]  D. Thijssen,et al.  Does arterial shear explain the magnitude of flow-mediated dilation?: a comparison between young and older humans. , 2009, American journal of physiology. Heart and circulatory physiology.

[39]  Z. Mareček,et al.  Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels , 1998 .

[40]  H. Schwertner,et al.  Association of low serum concentration of bilirubin with increased risk of coronary artery disease. , 1994, Clinical chemistry.

[41]  D A Grayson,et al.  Confounding confounding. , 1987, American journal of epidemiology.