Dihydrolipoyl dehydrogenase as a potential UVB target in skin epidermis; using an integrated approach of label-free quantitative proteomics and targeted metabolite analysis.

[1]  M. Oh,et al.  Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. , 2014, Journal of medicinal food.

[2]  M. Do,et al.  Dietary fermented soybean suppresses UVB-induced skin inflammation in hairless mice via regulation of the MAPK signaling pathway. , 2014, Journal of agricultural and food chemistry.

[3]  Jeong Kee Kim,et al.  MS-based metabolite profiling reveals time-dependent skin biomarkers in UVB-irradiated mice , 2014, Metabolomics.

[4]  Li-wen Ma,et al.  The Protective Effect of Baicalin against UVB Irradiation Induced Photoaging: An In Vitro and In Vivo Study , 2014, PloS one.

[5]  V. Titorenko,et al.  A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology☆ , 2014, Redox biology.

[6]  C. Lee,et al.  A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB‐Induced Skin Photoaging in vitro , 2013, Phytotherapy research : PTR.

[7]  Ho-Yeon Song,et al.  Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway. , 2013, Biological & pharmaceutical bulletin.

[8]  L. Hazrati,et al.  Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer’s disease and age-matched control brains , 2013, Clinical Proteomics.

[9]  D. Rabier,et al.  Dihydrolipoamide dehydrogenase deficiency: a still overlooked cause of recurrent acute liver failure and Reye-like syndrome. , 2013, Molecular genetics and metabolism.

[10]  L. Tretter,et al.  The role of mitochondrial dehydrogenases in the generation of oxidative stress , 2013, Neurochemistry International.

[11]  C. Milikowski,et al.  Comparative analysis of volatile metabolomics signals from melanoma and benign skin: a pilot study , 2013, Metabolomics.

[12]  T. Chou,et al.  The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1 , 2013, Evidence-based complementary and alternative medicine : eCAM.

[13]  D. Maria,et al.  Prognostic relationship of metabolic profile obtained of melanoma B16F10. , 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  Liang-Jun Yan,et al.  Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide , 2013, Free radical research.

[15]  Ishita Guha Thakurta,et al.  Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain , 2012, Biogerontology.

[16]  T. Metz,et al.  Metabolomic response of human skin tissue to low dose ionizing radiation. , 2012, Molecular bioSystems.

[17]  M. Verschoore,et al.  Cutaneous solar ultraviolet exposure and clinical aspects of photodamage. , 2012, Indian journal of dermatology, venereology and leprology.

[18]  A. Kimball A new era in skin care: the omics revolution , 2012, The British journal of dermatology.

[19]  A. Suhrbier,et al.  Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches. , 2012, The Journal of investigative dermatology.

[20]  P. Pinton,et al.  Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging , 2011, Journal of signal transduction.

[21]  J. Chung,et al.  Intrinsic aging- and photoaging-dependent level changes of glycosaminoglycans and their correlation with water content in human skin. , 2011, Journal of dermatological science.

[22]  Baoxi Wang,et al.  Proteome analysis of ultraviolet‐B‐induced protein expression in vitro human dermal fibroblasts , 2010, Photodermatology, photoimmunology & photomedicine.

[23]  G. Wondrak,et al.  Proteomic Identification of Cathepsin B and Nucleophosmin as Novel UVA‐Targets in Human Skin Fibroblasts , 2010, Photochemistry and photobiology.

[24]  A. Trifunovic,et al.  Mitochondrial energy metabolism and ageing. , 2010, Biochimica et biophysica acta.

[25]  B. Friguet,et al.  Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A , 2010, Biogerontology.

[26]  P. Schroeder,et al.  Role of mitochondria in photoaging of human skin: the defective powerhouse model. , 2009, The journal of investigative dermatology. Symposium proceedings.

[27]  H. Park,et al.  Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. , 2009, Journal of ethnopharmacology.

[28]  M. Mann,et al.  Universal sample preparation method for proteome analysis , 2009, Nature Methods.

[29]  M. Detmar,et al.  Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. , 2008, The American journal of pathology.

[30]  J. Tu,et al.  Effects of aloesin on melanogenesis in pigmented skin equivalents , 2008, International journal of cosmetic science.

[31]  A. Tiengo,et al.  Abnormal cytoskeletal protein expression in cultured skin fibroblasts from type 1 diabetes mellitus patients with nephropathy: A proteomic approach , 2008, Proteomics. Clinical applications.

[32]  J. Hwang,et al.  Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice. , 2007, Biological & pharmaceutical bulletin.

[33]  V. Appanna,et al.  The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist , 2007, PloS one.

[34]  J. Rocha,et al.  Antioxidant properties of Krebs cycle intermediates against malonate pro-oxidant activity in vitro: a comparative study using the colorimetric method and HPLC analysis to determine malondialdehyde in rat brain homogenates. , 2007, Life sciences.

[35]  J. Kopchick,et al.  Analysis of mouse skin reveals proteins that are altered in a diet‐induced diabetic state: A new method for detection of type 2 diabetes , 2007, Proteomics.

[36]  A. Mamelak,et al.  Photoaging: mechanisms and repair. , 2006, Journal of the American Academy of Dermatology.

[37]  L. Tretter,et al.  Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

[38]  M. O'Connell,et al.  α-Lipoic Acid-Induced Heme Oxygenase-1 Expression Is Mediated by Nuclear Factor Erythroid 2-Related Factor 2 and p38 Mitogen-Activated Protein Kinase in Human Monocytic Cells , 2005 .

[39]  Stephen Barnes,et al.  Prospective highlights of functional skin proteomics. , 2005, Mass spectrometry reviews.

[40]  J. Chung,et al.  Topical Application of 17β-Estradiol Increases Extracellular Matrix Protein Synthesis by Stimulating TGF-β Signaling in Aged Human Skin In Vivo , 2005 .

[41]  N. Gibbs,et al.  An action spectrum for the production of cis-urocanic acid in human skin in vivo. , 2005, The Journal of investigative dermatology.

[42]  M. Ponec,et al.  Proteomic profiling identifies an UV-induced activation of cofilin-1 and destrin in human epidermis. , 2005, The Journal of investigative dermatology.

[43]  R. S. Sohal,et al.  In the Aging Housefly Aconitase Is the Only Citric Acid Cycle Enzyme to Decline Significantly , 2005, Journal of bioenergetics and biomembranes.

[44]  J. Westpheling,et al.  The bkdR Gene of Streptomyces coelicolor Is Required for Morphogenesis and Antibiotic Production and Encodes a Transcriptional Regulator of a Branched-Chain Amino Acid Dehydrogenase Complex , 2005, Journal of bacteriology.

[45]  K. J. Krishnan,et al.  The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin. , 2004, The Journal of investigative dermatology.

[46]  M. Beal,et al.  Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species , 2004, The Journal of Neuroscience.

[47]  L. Tretter,et al.  Generation of Reactive Oxygen Species in the Reaction Catalyzed by α-Ketoglutarate Dehydrogenase , 2004, The Journal of Neuroscience.

[48]  G. Shukla,et al.  Serum prolactin levels for differentiation of nonepileptic versus true seizures: limited utility , 2004, Epilepsy & Behavior.

[49]  F. Bernerd,et al.  Matrix Metalloproteinase‐1 Production Observed After Solar‐Simulated Radiation Exposure is Assumed by Dermal Fibroblasts but Involves a Paracrine Activation Through Epidermal Keratinocytes ¶ , 2004, Photochemistry and photobiology.

[50]  E. Stadtman Role of oxidant species in aging. , 2004, Current medicinal chemistry.

[51]  T. Hagen,et al.  Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Jiankang Liu,et al.  (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. , 2004, Archives of biochemistry and biophysics.

[53]  N. Bresolin,et al.  Marked aging‐related decline in efficiency of oxidative phosphorylation in human skin fibroblasts , 2003, The FASEB Journal.

[54]  S. Takeo,et al.  [Anti-inflammatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinon VI in Salvia miltiorrhiza on heart]. , 2003, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[55]  S. Lowe,et al.  Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence , 2003, Cell.

[56]  A. Chiralt,et al.  Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. , 2002, Planta medica.

[57]  Sun-Lim Choi,et al.  Aloesin inhibits hyperpigmentation induced by UV radiation , 2002, Clinical and experimental dermatology.

[58]  B. Armstrong,et al.  The epidemiology of UV induced skin cancer. , 2001, Journal of photochemistry and photobiology. B, Biology.

[59]  P. Giacomoni Sun Protection in Man , 2001 .

[60]  Y. P. Lu,et al.  Time course for early adaptive responses to ultraviolet B light in the epidermis of SKH-1 mice. , 1999, Cancer research.

[61]  H. Mandel,et al.  Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews. , 1999, American journal of medical genetics.

[62]  J. Rees,et al.  Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging. , 1998, The Journal of investigative dermatology.

[63]  R. Eckert,et al.  Epidermal keratinocytes - genes and their regulation. , 1996, Cell death and differentiation.

[64]  S. Fleming,et al.  The TCA cycle as an oxidative and synthetic pathway is suppressed with aging in jejunal epithelial cells. , 1994, Canadian journal of physiology and pharmacology.

[65]  B. Robinson,et al.  The structure of the human dihydrolipoamide dehydrogenase gene (DLD) and its upstream elements. , 1993, Genomics.

[66]  G. Pons,et al.  Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases. , 1989, Archives of biochemistry and biophysics.

[67]  M. Danson Dihydrolipoamide dehydrogenase: a 'new' function for an old enzyme? , 1988, Biochemical Society transactions.

[68]  S. Goldstein,et al.  Energy metabolism in cultured human fibroblasts during aging in vitro , 1982, Journal of cellular physiology.

[69]  B. Robinson,et al.  Lactic acidemia, neurologic deterioration and carbohydrate dependence in a girl with dihydrolipoyl dehydrogenase deficiency , 1981, European Journal of Pediatrics.

[70]  B. Robinson,et al.  Deficiency of Dihydrolipoyl Dehydrogenase (a Component of the Pyruvate and α-Ketoglutarate Dehydrogenase Complexes): A Cause of Congenital Chronic Lactic Acidosis in Infancy , 1977, Pediatric Research.

[71]  Reed Lj,et al.  The multienzyme alpha-keto acid dehydrogenase complexes. , 1968 .

[72]  Donna M. Martin,et al.  Leigh syndrome in a girl with a novel DLD mutation causing E3 deficiency. , 2013, Pediatric neurology.

[73]  Xiao-yi Hu,et al.  [The effect of aloesin on melanocytes in the pigmented skin equivalent model]. , 2008, Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery.

[74]  M. O'Connell,et al.  Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[75]  J. Chung,et al.  Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. , 2005, The Journal of investigative dermatology.

[76]  M. Beal,et al.  Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[77]  L. Tretter,et al.  Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[78]  J. Schalkwijk,et al.  Transcriptomics and proteomics of human skin. , 2003, Briefings in functional genomics & proteomics.

[79]  F. Bernerd,et al.  Direct role of human dermal fibroblasts and indirect participation of epidermal keratinocytes in MMP-1 production after UV-B irradiation , 2001, Archives of Dermatological Research.

[80]  M. Patel,et al.  Lipoic acid as an antioxidant. The role of dihydrolipoamide dehydrogenase. , 1998, Methods in molecular biology.

[81]  Young-Soo Hong,et al.  Lipoic Acid as an Antioxidant , 1998 .

[82]  R. Wolfe,et al.  Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. , 1991, Surgery.

[83]  R. M. Oliver,et al.  The multienzyme alpha-keto acid dehydrogenase complexes. , 1968, Brookhaven symposia in biology.