Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study

Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T‐antigens) have been correlated with MCC tumor burden. The present study assesses the clinical utility of MCPyV‐oncoprotein antibody titers for MCC prognostication and surveillance.

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