This letter reports observations of the 51.8-micron fine-structure transition p2: 3P(2) - 3P(1) for doubly ionized oxygen. The observed line strength in the Orion Nebula is (5 + or - 3) by 10 to the -15th power W/sq cm, in good agreement with the theoretical predictions of Simpson (1975). The observations are also consistent with the predicted line position, 51.8 microns. The line lies close to an atmospheric water-vapor feature at 51.7 microns but is sufficiently distant so that corrections for this feature are straightforward. Observations of the 51.8-micron forbidden O III line are particularly important, since the previously discovered 88-micron line from the same ion also is strong. This pair of lines should therefore yield new data about densities in observed H II regions; or else, if density data already are available from radio or other observations, the lines can be used to determine the differential dust absorption between 52 and 88 microns in front of heavily obscured regions.