论文信息 - Long-range repression in the Drosophila embryo.

Long-range repression in the Drosophila embryo.

Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.

M. Levine | D. Arnosti | H. Cai

[1] Jun Ma,et al. An HMG-like protein that can switch a transcriptional activator to a repressor , 1994, Nature.

[2] M. Levine,et al. Spacing ensures autonomous expression of different stripe enhancers in the even-skipped promoter. , 1993, Development.

[3] C. Nüsslein-Volhard,et al. Genes affecting the segmental subdivision of the Drosophila embryo. , 1985, Cold Spring Harbor symposia on quantitative biology.