The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.

[1]  M. Griswold,et al.  Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. , 2011, Journal of andrology.

[2]  Patrick W. Lee,et al.  Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis , 2011, Stem cells.

[3]  L. Nicholson,et al.  Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? , 2010, The Journal of pathology.

[4]  K. Barth,et al.  Disulfiram: an old therapeutic with new applications. , 2010, CNS & neurological disorders drug targets.

[5]  S. Choe,et al.  Maternal and Zygotic aldh1a2 Activity Is Required for Pancreas Development in Zebrafish , 2009, PloS one.

[6]  D. Overstreet,et al.  A selective ALDH-2 inhibitor reduces anxiety in rats , 2009, Pharmacology Biochemistry and Behavior.

[7]  A. Bairoch,et al.  Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature , 2009, Pharmacogenetics and genomics.

[8]  S. Yin,et al.  Substrate specificity of human and yeast aldehyde dehydrogenases. , 2009, Chemico-biological interactions.

[9]  Gregg Duester,et al.  Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. , 2009, Blood.

[10]  J. Moreb Aldehyde dehydrogenase as a marker for stem cells. , 2008, Current stem cell research & therapy.

[11]  H. Baker,et al.  ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells , 2008, Molecular Cancer.

[12]  C. Brocker,et al.  Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily , 2008, Expert opinion on drug metabolism & toxicology.

[13]  Henry V. Baker,et al.  ALDH isozymes downregulation effects on cell growth and gene expression in lung cancer cell lines , 2007 .

[14]  J. Moreb,et al.  Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry‐based assay , 2007, Cytometry. Part B, Clinical cytometry.

[15]  J. Moreb,et al.  RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide , 2006, Cancer Chemotherapy and Pharmacology.

[16]  Y. Koutalos,et al.  Human Aldehyde Dehydrogenase 3A1 Inhibits Proliferation and Promotes Survival of Human Corneal Epithelial Cells* , 2005, Journal of Biological Chemistry.

[17]  D. Niedzwiecki,et al.  Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. , 2005, Blood.

[18]  Vasilis Vasiliou,et al.  Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family , 2005, Human Genomics.

[19]  T. Lister,et al.  Characterization of Cells with a High Aldehyde Dehydrogenase Activity from Cord Blood and Acute Myeloid Leukemia Samples , 2005, Stem cells.

[20]  N. Kröger,et al.  Aldehyde dehydrogenase activity as a marker for the quality of hematopoietic stem cell transplants , 2005, Bone Marrow Transplantation.

[21]  D. Mohuczy,et al.  Retinoic Acid Down-Regulates Aldehyde Dehydrogenase and Increases Cytotoxicity of 4-Hydroperoxycyclophosphamide and Acetaldehyde , 2005, Journal of Pharmacology and Experimental Therapeutics.

[22]  M. Stojkovic,et al.  Phenotypic Characterization of Murine Primitive Hematopoietic Progenitor Cells Isolated on Basis of Aldehyde Dehydrogenase Activity , 2004, Stem cells.

[23]  J. Nolta,et al.  Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. , 2004, Blood.

[24]  V. Vasiliou,et al.  Role of Human Aldehyde Dehydrogenases in Endobiotic and Xenobiotic Metabolism , 2004, Drug metabolism reviews.

[25]  P. Chambon,et al.  A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  V. Vasiliou,et al.  Aldehyde dehydrogenase gene superfamily: the 2002 update. , 2003, Chemico-biological interactions.

[27]  U. Reichert,et al.  The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death. , 2001, Chemico-biological interactions.

[28]  N. Sládek,et al.  Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues. , 2001, Chemico-biological interactions.

[29]  V. Vasiliou,et al.  Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. , 2000, Chemico-biological interactions.

[30]  V. Vasiliou,et al.  Polymorphisms of Human Aldehyde Dehydrogenases , 2000, Pharmacology.

[31]  M. Schweder,et al.  Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro. , 2000, The Journal of pharmacology and experimental therapeutics.

[32]  O. Colvin,et al.  Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[33]  N. Sládek Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines. , 1999, Current pharmaceutical design.

[34]  A. Bairoch,et al.  Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. , 1999, Pharmacogenetics.

[35]  P. Chambon,et al.  Embryonic retinoic acid synthesis is essential for early mouse post-implantation development , 1999, Nature Genetics.

[36]  A Yoshida,et al.  Human aldehyde dehydrogenase gene family. , 1998, European journal of biochemistry.

[37]  U. Dräger,et al.  Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development , 1997, Mechanisms of Development.

[38]  A. Townsend,et al.  Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme. , 1996, The Journal of biological chemistry.

[39]  A. Klyosov Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes. , 1996, Biochemistry.

[40]  Richard J. Jones,et al.  Assessment of aldehyde dehydrogenase in viable cells. , 1995, Blood.

[41]  V. Vasiliou,et al.  Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a , 1993, Annals of the New York Academy of Sciences.

[42]  B. Johansson A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites , 1992, Acta psychiatrica Scandinavica. Supplementum.

[43]  J. Russo,et al.  Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells. , 1988, Cancer research.

[44]  N. Sládek Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact , 2003, Journal of biochemical and molecular toxicology.

[45]  V. Vasiliou,et al.  Aldehyde Dehydrogenase Gene Superfamily , 1999 .

[46]  R. Lindahl,et al.  Aldehyde dehydrogenases and their role in carcinogenesis. , 1992, Critical reviews in biochemistry and molecular biology.

[47]  D. Agarwal,et al.  Pharmacogenetics of aldehyde dehydrogenase (ALDH). , 1990, Pharmacology & therapeutics.

[48]  P. A. Maki,et al.  Xenobiotic oxidation catalyzed by aldehyde dehydrogenases. , 1989, Drug metabolism reviews.

[49]  Agarwal Dp,et al.  Human aldehyde dehydrogenase isozymes and alcohol sensitivity. , 1987 .

[50]  R. Pietruszko Aldehyde dehydrogenase isozymes. , 1983, Isozymes.

[51]  G. S. Whitt,et al.  Isozymes : current topics in biological and medical research , 1977 .