The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia

[1]  S. Heatley,et al.  Exploring the oncogenic and therapeutic target potential of the MYB-TYK2 fusion gene in B-cell acute lymphoblastic leukemia , 2022, Cancer Gene Therapy.

[2]  Yuan Gao,et al.  MAD2L1 Functions As a Novel Diagnostic and Predictive Biomarker in Cholangiocarcinoma. , 2021, Genetic testing and molecular biomarkers.

[3]  Yusheng Chen,et al.  Bioinformatics study on genes related to a high-risk postoperative recurrence of lung adenocarcinoma , 2021, Science progress.

[4]  Xu-Qing Tang,et al.  Bioinformatics screening of biomarkers related to liver cancer , 2021, BMC Bioinformatics.

[5]  Xiaona Lu,et al.  Identification of novel hub genes associated with gastric cancer using integrated bioinformatics analysis , 2020, BMC Cancer.

[6]  C. Mullighan,et al.  Pediatric acute lymphoblastic leukemia , 2020, Haematologica.

[7]  R. Perona,et al.  Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines , 2020, Theranostics.

[8]  X. Xi,et al.  Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis , 2019, The journal of obstetrics and gynaecology research.

[9]  M. Galibert,et al.  Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues. , 2019, Blood reviews.

[10]  Ju-Han Lee,et al.  Spindle assembly checkpoint MAD2 and CDC20 overexpressions and cell-in-cell formation in gastric cancer and its precursor lesions. , 2019, Human pathology.

[11]  B. Groner,et al.  Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition , 2017, Molecular and Cellular Endocrinology.

[12]  Kuen-Feng Chen,et al.  Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis , 2017, Scientific Reports.

[13]  Kuen-Feng Chen,et al.  Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. , 2017, Oncotarget.

[14]  C. V. D. Schoot,et al.  Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences , 2017, Leukemia.

[15]  Damian Szklarczyk,et al.  The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible , 2016, Nucleic Acids Res..

[16]  Xia Gao,et al.  Identification of genes involved in Epstein-Barr virus-associated nasopharyngeal carcinoma , 2016, Oncology letters.

[17]  Yinghong Tian,et al.  Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway , 2016, Neuroscience Letters.

[18]  R. Pieters,et al.  New cellular markers at diagnosis are associated with isolated central nervous system relapse in paediatric B‐cell precursor acute lymphoblastic leukaemia , 2016, British journal of haematology.

[19]  R. Buettner,et al.  Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation. , 2016, Journal of molecular biology.

[20]  M. Kelsh,et al.  Acute lymphoblastic leukemia: an assessment of international incidence, survival, and disease burden , 2015, Cancer Causes & Control.

[21]  Hua Yu,et al.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions , 2014, Nature Reviews Cancer.

[22]  Ahmedin Jemal,et al.  Childhood and adolescent cancer statistics, 2014 , 2014, CA: a cancer journal for clinicians.

[23]  H. Sîrbu,et al.  Establishing the role of tyrosine kinase 2 in cancer , 2013, Oncoimmunology.

[24]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[25]  O. Sheils,et al.  Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer , 2012, The Journal of pathology.

[26]  F. Staal,et al.  Genome-wide expression analysis of paired diagnosis–relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype , 2010, Leukemia.

[27]  Nicholas D. Socci,et al.  Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal , 2010, Nature.

[28]  P. Gaynon.  Childhood acute lymphoblastic leukaemia and relapse , 2005, British journal of haematology.

[29]  Geert J. P. L. Kops,et al.  On the road to cancer: aneuploidy and the mitotic checkpoint , 2005, Nature Reviews Cancer.

[30]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Artwohl,et al.  TYK2 is a key regulator of the surveillance of B lymphoid tumors. , 2004, The Journal of clinical investigation.

[32]  E. Dı́az-Rodrı́guez,et al.  Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Hua Yu,et al.  The STATs of cancer — new molecular targets come of age , 2004, Nature Reviews Cancer.

[34]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[35]  J. Darnell.  STATs and gene regulation. , 1997, Science.

[36]  Mathias Müller,et al.  Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. , 2017, Cytokine.

[37]  S. Lowe,et al.  Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. , 2007, Cancer cell.

[38]  Hua Yu,et al.  Tumour immunology: Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment , 2007, Nature Reviews Immunology.