Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes
暂无分享,去创建一个
G. Mufti | P. Fenaux | U. Germing | A. Giagounidis | A. List | K. Macbeth
[1] A. Karsan,et al. Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34+ cells from patients with del(5q) myelodysplastic syndrome , 2013, Haematologica.
[2] G. Mufti,et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis , 2013, British journal of haematology.
[3] J. Clark,et al. Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion , 2013, Oncogene.
[4] A. Glasmacher,et al. Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis , 2012, Leukemia.
[5] J. Gribben,et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. , 2012, Blood.
[6] A. List,et al. Lenalidomide for treatment of myelodysplastic syndromes. , 2012, Current pharmaceutical design.
[7] A. Jankowska,et al. Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] S. Chevret,et al. Treatment with lenalidomide does not appear to increase the risk of progression in lower risk myelodysplastic syndromes with 5q deletion. A comparative analysis by the Groupe Francophone des Myelodysplasies , 2012, Haematologica.
[9] R. Schlenk,et al. Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study , 2012, Leukemia.
[10] M. Cazzola,et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q. , 2011, Blood.
[11] D. Neuberg,et al. Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis , 2011, Blood.
[12] Eva Hellström-Lindberg,et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[13] P. Fenaux,et al. 58 Interaction of karyotype complexity and response on overall survival and AML progression in lenalidomide-treated Low/INT-1 risk del (5q) MDS patients , 2011 .
[14] J. Kutok,et al. Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. , 2011, Blood.
[15] E. Padron,et al. Biology and treatment of the 5q- syndrome , 2011, Expert review of hematology.
[16] P. Fenaux,et al. Cytogenetic follow-up by karyotyping and fluorescence in situ hybridization: implications for monitoring patients with myelodysplastic syndrome and deletion 5q treated with lenalidomide , 2011, Haematologica.
[17] C. Steidl,et al. Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q , 2011, Leukemia.
[18] A. McKenzie,et al. Advances in the 5q- syndrome. , 2010, Blood.
[19] R. Latagliata,et al. Increases In Mirna-145 and Mirna-146a Expression In Patients with IPSS Lower-Risk Myelodysplastic Syndromes and Del(5q) Treated with Lenalidomide. , 2010 .
[20] R. Chopra,et al. Pleiotropic mechanisms of action of lenalidomide efficacy in del(5q) myelodysplastic syndromes , 2010, Expert review of anticancer therapy.
[21] L. Trümper,et al. FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: verification of the method and application to 27 MDS patients. , 2010, Leukemia research.
[22] P. Woll,et al. Persistent malignant stem cells in del(5q) myelodysplasia in remission. , 2010, The New England journal of medicine.
[23] R. Latagliata,et al. Changes in RPS14 expression levels during lenalidomide treatment in Low‐ and Intermediate‐1‐risk myelodysplastic syndromes with chromosome 5q deletion , 2010, European journal of haematology.
[24] M. Laouri,et al. Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] A. Tefferi,et al. WHO-defined ‘myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations , 2010, Leukemia.
[26] M. L. Le Beau,et al. Haploinsufficiency of Apc leads to ineffective hematopoiesis. , 2010, Blood.
[27] David A. Williams,et al. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. , 2010, Blood.
[28] B. Ebert,et al. Ribosomopathies: human disorders of ribosome dysfunction. , 2010, Blood.
[29] S. Pileri,et al. Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome. , 2010, Blood.
[30] P. Korkolopoulou,et al. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion , 2010, Haematologica.
[31] M. Jädersten. Pathophysiology and treatment of the myelodysplastic syndrome with isolated 5q deletion , 2010, Haematologica.
[32] Y. Tohyama,et al. Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis , 2010, Leukemia.
[33] A. Warren,et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q− syndrome , 2009, Nature Medicine.
[34] Ryan D. Morin,et al. Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype , 2010, Nature Medicine.
[35] E. Hellström-Lindberg,et al. Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression , 2010, Annals of Hematology.
[36] H. Kreipe,et al. Anti-Angiogenic in-Vivo Effect of Lenalidomide and Its Impact On Neoplastic and Non-Neoplastic Hematopoiesis in MDS with Del(5q) Chromosome Abnormality. , 2009 .
[37] J. Issa,et al. The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities , 2009, Cancer.
[38] Karl J. Dykema,et al. 5q– myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics , 2009, Oncogene.
[39] G. Prendergast,et al. Loss of RhoB Expression Enhances the Myelodysplastic Phenotype of Mammalian Diaphanous-Related Formin mDia1 Knockout Mice , 2009, PloS one.
[40] J. Byrd,et al. A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide , 2009, Proceedings of the National Academy of Sciences.
[41] Lei Wu,et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. , 2009, Microvascular research.
[42] J. Maciejewski,et al. Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[43] P. Schafer,et al. Direct Inhibitory Effects of Lenalidomide on the Proliferation and VEGF Production of Non-Hodgkin Lymphoma Cells Are Associated with Increased SPARC Expression , 2008 .
[44] S. Nimer,et al. Myelodysplastic syndromes: diagnosis and staging. , 2008, Cancer control : journal of the Moffitt Cancer Center.
[45] H. Dombret,et al. Treatment of myelodysplastic syndromes with 5q deletion before the lenalidomide era; the GFM experience with EPO and thalidomide. , 2008, Leukemia research.
[46] J. Clohessy,et al. Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse. , 2008, Blood.
[47] T. Golub,et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen , 2007, Nature.
[48] Thomas H Müller,et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. , 2007, Blood.
[49] M. Cazzola,et al. Gene expression profiling of CD34+ cells in patients with the 5q− syndrome , 2007, British journal of haematology.
[50] K. Eisenmann,et al. Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1. , 2007, Cancer research.
[51] S. Lehmann,et al. Common deleted genes in the 5q− syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice , 2007, Leukemia.
[52] B. Sander,et al. Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q− syndrome patients , 2007, Proceedings of the National Academy of Sciences.
[53] A. Beggs,et al. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. , 2006, American journal of human genetics.
[54] S. Green,et al. Lenalidomide: targeted anemia therapy for myelodysplastic syndromes. , 2006, Cancer control : journal of the Moffitt Cancer Center.
[55] P. Greenberg,et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. , 2006, The New England journal of medicine.
[56] M. Cazzola,et al. Predicting survival and leukemic evolution in patients with myelodysplastic syndrome. , 2006, Haematologica.
[57] J. Bennett,et al. Anti-Angiogenic In Vivo Effect of Lenalidomide (CC-5013) in Myelodysplastic Syndrome with del(5q) Chromosome Abnormality and Its Relation to the Course of Disease. , 2005 .
[58] Luca Malcovati,et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[59] B. Dimitrov,et al. Hemoglobin level threshold for cardiac remodeling and quality of life in myelodysplastic syndrome. , 2005, Leukemia research.
[60] L. Rimsza,et al. Efficacy of lenalidomide in myelodysplastic syndromes. , 2005, The New England journal of medicine.
[61] A. Dalgleish,et al. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects , 2002, British Journal of Cancer.
[62] N. Harris,et al. The World Health Organization (WHO) classification of the myeloid neoplasms. , 2002, Blood.
[63] A. Kasprzyk,et al. Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome. , 2002, Blood.
[64] M. Taniwaki,et al. International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome , 2001, British journal of haematology.
[65] D. Christiansen,et al. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[66] S. E. Jacobsen,et al. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. , 2000, Blood.
[67] P. Haslett,et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. , 1999, Journal of immunology.
[68] R. D'Agostino. Adjustment Methods: Propensity Score Methods for Bias Reduction in the Comparison of a Treatment to a Non‐Randomized Control Group , 2005 .
[69] R. Larson,et al. Polymerase chain reaction-based diagnosis of del (5q) in acute myeloid leukemia and myelodysplastic syndrome identifies a minimal deletion interval. , 1996, Blood.
[70] H. Kaneko,et al. TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities. , 1995, Blood.