T-cell development and the CD4–CD8 lineage decision

[1]  A. McMichael,et al.  Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment , 2001, Nature Immunology.

[2]  Pamela S. Ohashi,et al.  Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection1 , 2001, The Journal of Immunology.

[3]  J. Pongrácz,et al.  Notch ligand‐bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling , 2001, European journal of immunology.

[4]  D. Littman,et al.  Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage , 2001, Nature Genetics.

[5]  H. Macdonald,et al.  Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus , 2001, The Journal of experimental medicine.

[6]  R. Germain.  The T Cell Receptor for Antigen: Signaling and Ligand Discrimination* , 2001, The Journal of Biological Chemistry.

[7]  C. Murre,et al.  Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity , 2001, The Journal of experimental medicine.

[8]  C Benoist,et al.  A molecular chart of thymocyte positive selection , 2001, European journal of immunology.

[9]  S. Egan,et al.  Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. , 2001, Immunity.

[10]  J. Kaye,et al.  Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model. , 2001, Cellular immunology.

[11]  B. Sefton,et al.  Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase* , 2001, The Journal of Biological Chemistry.

[12]  G. Weinmaster,et al.  Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1 , 2001, The Journal of Immunology.

[13]  W. Pear,et al.  Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. , 2001, Immunity.

[14]  H. Macdonald,et al.  Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development , 2001, Nature Immunology.

[15]  C. Murre,et al.  Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade , 2001, Nature Immunology.

[16]  P. Ohashi,et al.  The Quantity of TCR Signal Determines Positive Selection and Lineage Commitment of T Cells1 , 2000, The Journal of Immunology.

[17]  M. Freeman.  Feedback control of intercellular signalling in development , 2000, Nature.

[18]  Bruno Lucas,et al.  TCR Signaling for Initiation and Completion of Thymocyte Positive Selection Has Distinct Requirements for Ligand Quality and Presenting Cell Type , 2000, The Journal of Immunology.

[19]  E. Rothenberg.  Stepwise specification of lymphocyte developmental lineages. , 2000, Current opinion in genetics & development.

[20]  M. Bevan,et al.  Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. , 2000, Immunity.

[21]  A. Singer,et al.  Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. , 2000, Immunity.

[22]  A. Weiss,et al.  Signal transduction by the TCR for antigen. , 2000, Current opinion in immunology.

[23]  D. Kioussis,et al.  Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. , 2000, Immunity.

[24]  E. Robey,et al.  Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment. , 2000, Immunity.

[25]  P. Ohashi,et al.  Degree of ERK activation influences both positive and negative thymocyte selection , 2000, European journal of immunology.

[26]  R. Germain,et al.  The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate , 2000, Nature.

[27]  J. Alberola-Ila,et al.  Lck activity controls CD4/CD8 T cell lineage commitment. , 2000, Immunity.

[28]  Thomas M. Schmitt,et al.  Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus1 , 2000, The Journal of Immunology.

[29]  U. Lorenz,et al.  The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. , 1999, International immunology.

[30]  B. Osborne,et al.  Notch and the immune system. , 1999, Immunity.

[31]  A. Singer,et al.  Association of the Adaptor Molecule Lat with Cd4 and Cd8 Coreceptors Identifies a New Coreceptor Function in T Cell Receptor Signal Transduction , 1999, The Journal of experimental medicine.

[32]  J. Pouysségur,et al.  Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. , 1999, Science.

[33]  K. Siminovitch,et al.  Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. , 1999, Journal of immunology.

[34]  J. Aster,et al.  Notch1 expression in early lymphopoiesis influences B versus T lineage determination. , 1999, Immunity.

[35]  J. Kaye,et al.  Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression. , 1999, Journal of immunology.

[36]  M. A. Basson,et al.  Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus. , 1999, Journal of immunology.

[37]  H. Fehling,et al.  Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex , 1999, The Journal of experimental medicine.

[38]  A Gulino,et al.  Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. , 1999, International immunology.

[39]  P. Allen,et al.  Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. , 1999, Journal of immunology.

[40]  H. Macdonald,et al.  Deficient T cell fate specification in mice with an induced inactivation of Notch1. , 1999, Immunity.

[41]  L. Borysiewicz,et al.  TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. , 1999, Journal of immunology.

[42]  R. Germain,et al.  Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. , 1999, Immunity.

[43]  C. Benoist,et al.  Visualization of CD4/CD8 T Cell Commitment , 1998, The Journal of experimental medicine.

[44]  H. Kim,et al.  The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression , 1998, Molecular and Cellular Biology.

[45]  S. Jameson,et al.  Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells , 1998, The Journal of experimental medicine.

[46]  D. Kioussis,et al.  Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. , 1998, Immunity.

[47]  C. Benoist,et al.  CD4/CD8 lineage commitment: matching fate with competence , 1998, Immunological reviews.

[48]  M. A. Basson,et al.  Molecular requirements for lineage commitment in the thymus – antibody‐mediated receptor engagements reveal a central role for lck in lineage decisions , 1998, Immunological reviews.

[49]  C. Janeway,et al.  A molecular map of T cell development. , 1998, Immunity.

[50]  S. Eliason,et al.  Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. , 1998, Science.

[51]  U. Bommhardt,et al.  CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of  T Cell Receptor Specificity , 1998, The Journal of experimental medicine.

[52]  J. Riberdy,et al.  Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[53]  L. Samelson,et al.  LAT The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation , 1998, Cell.

[54]  E. Rubin,et al.  A role for Ras signaling in coreceptor regulation during differentiation of a double-positive thymocyte cell line. , 1997, Journal of immunology.

[55]  C. Marshall,et al.  The influence of the MAPK pathway on T cell lineage commitment. , 1997, Immunity.

[56]  A. Berns,et al.  Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules , 1997, The Journal of experimental medicine.

[57]  A. Fisher,et al.  How Many Thymocytes Audition for Selection? , 1997, The Journal of experimental medicine.

[58]  D. Kioussis,et al.  A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. , 1997, Immunity.

[59]  K. Losos,et al.  An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. , 1997, Immunity.

[60]  Y. Chien,et al.  CD4 augments the response of a T cell to agonist but not to antagonist ligands. , 1997, Immunity.

[61]  E. Robey.  Notch in vertebrates. , 1997, Current opinion in genetics & development.

[62]  H. Pircher,et al.  Differentiation of CD4highCD8low coreceptor‐skewed thymocytes into mature CD8 single‐positive cells independent of MHC class I recognition , 1997, European journal of immunology.

[63]  Y. Zhao,et al.  Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity. , 1997, Journal of immunology.

[64]  D. D. Duncan,et al.  Positive selection induces CD4 promoter and enhancer function. , 1997, International immunology.

[65]  W. Fung-Leung,et al.  Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. , 1997, Immunity.

[66]  U. Bommhardt,et al.  Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus , 1997, European journal of immunology.

[67]  M. Bevan,et al.  CD8 lineage commitment in the absence of CD8. , 1997, Immunity.

[68]  D. Kioussis,et al.  A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. , 1997, Journal of immunology.

[69]  J. Zerrahn,et al.  The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection , 1997, Cell.

[70]  R. Germain,et al.  The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands , 1997, The Journal of experimental medicine.

[71]  G. Weinmaster,et al.  An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages , 1996, Cell.

[72]  R. Germain,et al.  Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. , 1996, Immunity.

[73]  A. Weiss,et al.  αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases , 1996 .

[74]  A. Hayday,et al.  Raf regulates positive selection , 1996, European journal of immunology.

[75]  K. Ravichandran,et al.  Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[76]  K. Siminovitch,et al.  Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase , 1996, The Journal of experimental medicine.

[77]  R. Perlmutter,et al.  Positive and negative selection invoke distinct signaling pathways , 1996, The Journal of experimental medicine.

[78]  D. Plas,et al.  Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling , 1996, Science.

[79]  N. Killeen,et al.  MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. , 1996, Immunity.

[80]  D. Kioussis,et al.  The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells , 1996, The Journal of experimental medicine.

[81]  H. Boehmer.  CD4/CD8 lineage commitment: back to instruction? , 1996 .

[82]  H. von Boehmer,et al.  CD4/CD8 lineage commitment: back to instruction? , 1996, The Journal of experimental medicine.

[83]  R W Wilkinson,et al.  Positive selection of thymocytes involves sustained interactions with the thymic microenvironment. , 1995, Journal of immunology.

[84]  A. Weiss,et al.  The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit , 1995, The Journal of experimental medicine.

[85]  K. Nakayama,et al.  Essential role for ZAP-70 in both positive and negative selection of thymocytes , 1995, Nature.

[86]  R. Germain,et al.  Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. , 1995, Journal of immunology.

[87]  P. Kisielow,et al.  Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor , 1995, The Journal of experimental medicine.

[88]  W. Heath,et al.  Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes , 1995, The Journal of experimental medicine.

[89]  A. Singer,et al.  Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. , 1995, Immunity.

[90]  E. Krebs,et al.  Selective requirement for MAP kinase activation in thymocyte differentiation , 1995, Nature.

[91]  S. Hedrick,et al.  Role of TCR specificity in CD4 versus CD8 lineage commitment. , 1995, Journal of immunology.

[92]  H. Pircher,et al.  Evidence for a selective and multi‐step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules , 1994, European journal of immunology.

[93]  C. Benoist,et al.  In favor of the selective model of positive selection. , 1994, Seminars in immunology.

[94]  F. Chan,et al.  A role for the cytoplasmic tail of the β chain of CD8 in thymic selection , 1994 .

[95]  D. Littman,et al.  A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development , 1994, Cell.

[96]  G. Linette,et al.  Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. , 1994, Immunity.

[97]  W. Fanslow,et al.  Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice , 1994, The Journal of experimental medicine.

[98]  D. Littman,et al.  Thymocyte lineage commitment: is it instructed or stochastic? , 1994, Current opinion in immunology.

[99]  Dan R. Littman,et al.  Signal transduction by lymphocyte antigen receptors , 1994, Cell.

[100]  Ronald N. Germain,et al.  MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation , 1994, Cell.

[101]  D. Kioussis,et al.  Stochastic component to development of class I major histocompatibility complex-specific T cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[102]  L. Glimcher,et al.  Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[103]  R. Klausner,et al.  Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules , 1993, The Journal of experimental medicine.

[104]  A. Hayday,et al.  A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein , 1993, Cell.

[105]  R. Germain,et al.  Development of mature CD8+ thymocytes: selection rather than instruction? , 1993, Science.

[106]  A. Zlotnik,et al.  A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. , 1993, Journal of immunology.

[107]  C. Benoist,et al.  Another view of the selective model of thymocyte selection , 1993, Cell.

[108]  D. Littman,et al.  Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes , 1993, Cell.

[109]  H. Boehmer,et al.  Lymphocyte lineage commitment: Instruction versus selection , 1993, Cell.

[110]  G. Anderson,et al.  MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus , 1993, Nature.

[111]  F. Alt,et al.  Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. , 1993, Science.

[112]  W. Swat,et al.  Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes , 1992, European journal of immunology.

[113]  R. Seong,et al.  Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail , 1992, Nature.

[114]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[115]  W. Paul,et al.  Activation events during thymic selection , 1992, The Journal of experimental medicine.

[116]  D. Littman,et al.  Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. , 1991, Molecular and cellular biology.

[117]  H. Kishi,et al.  Development of the CD4 and CD8 lineage of T cells: instruction versus selection. , 1991, The EMBO journal.

[118]  D. Kioussis,et al.  Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage , 1991, Cell.

[119]  I. Weissman,et al.  T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages , 1990, The Journal of experimental medicine.

[120]  J. Bolen,et al.  Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways , 1989, The Journal of experimental medicine.

[121]  S. Jameson,et al.  Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor , 1989, Nature.

[122]  D. Longo,et al.  Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selection , 1989, The Journal of experimental medicine.

[123]  Polly Matzinger,et al.  Does T-cell tolerance require a dedicated antigen-presenting cell? , 1989, Nature.

[124]  H. von Boehmer,et al.  The thymus selects the useful, neglects the useless and destroys the harmful. , 1989, Immunology today.

[125]  Y. Uematsu,et al.  Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells , 1988, Nature.

[126]  Mark M. Davis,et al.  T-cell antigen receptor genes and T-cell recognition , 1988, Nature.

[127]  H. Boehmer,et al.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.

[128]  B. Fowlkes,et al.  Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A- bearing antigen-presenting cell function , 1985, The Journal of experimental medicine.

[129]  S. Swain.  T Cell Subsets and the Recognition of MHC Class , 1983, Immunological reviews.

[130]  W. Biddison,et al.  Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens , 1982, The Journal of experimental medicine.

[131]  T. Pawson,et al.  Disruption of T cell signaling networks and development by Grb2 haploid insufficiency , 2001, Nature Immunology.

[132]  H. Macdonald,et al.  Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. , 2001, Nature immunology.

[133]  D. Littman,et al.  The regulation of CD4 and CD8 coreceptor gene expression during T cell development. , 1999, Annual review of immunology.

[134]  J. Leiden,et al.  Transcriptional regulation of T lymphocyte development and function. , 1999, Annual review of immunology.

[135]  R. Germain,et al.  The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. , 1999, Annual review of immunology.

[136]  A. F. Campese,et al.  Expression pattern of Notch 1 , 2 and 3 and Jagged 1 and 2 in lymphoid and stromal thymus components : distinct ligand – receptor interactions in intrathymic T cell development , 1999 .

[137]  H. Fehling,et al.  Structure and function of the pre-T cell receptor. , 1997, Annual review of immunology.

[138]  A. Weiss,et al.  The PreT Cell Receptor ( TCR ) Complex is Functionally Coupled to the TCR-~ Subunit , 1995 .

[139]  R. Perlmutter,et al.  Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. , 1994, Advances in immunology.

[140]  B. Fowlkes,et al.  Selective events in T cell development. , 1994, Annual review of immunology.

[141]  C. Janeway.  The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. , 1992, Annual review of immunology.

[142]  D. Pardoll,et al.  Molecular mechanisms for lineage commitment in T cell development. , 1990, Seminars in Immunology.

[143]  Paul Waltman,et al.  A Threshold Model , 1974 .