Evidence of recurrent gene fusions in common epithelial tumors.
暂无分享,去创建一个
[1] F. Mertens,et al. Successful treatment of a child with t(15;19)‐positive tumor , 2007, Pediatric blood & cancer.
[2] I. Panagopoulos,et al. Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer , 2006 .
[3] A. Evans,et al. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. , 2006, Neoplasia.
[4] David E. Misek,et al. Delineation, Functional Validation, and Bioinformatic Evaluation of Gene Expression in Thyroid Follicular Carcinomas with the PAX8-PPARG Translocation , 2006, Clinical Cancer Research.
[5] Arul M Chinnaiyan,et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. , 2006, Cancer research.
[6] M. Dictor,et al. Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy , 2006, BMC Cancer.
[7] J. Tchinda,et al. Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer , 2005, Science.
[8] J. Minna,et al. Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro , 2005, Journal of Medical Genetics.
[9] G. Stenman. Fusion oncogenes and tumor type specificity--insights from salivary gland tumors. , 2005, Seminars in cancer biology.
[10] L. Manuelidis,et al. Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes , 1988, Human Genetics.
[11] C. Antonescu,et al. Midline carcinoma of children and young adults with NUT rearrangement. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] N. Eberhardt,et al. The PAX8/PPAR gamma fusion oncogene as a potential therapeutic target in follicular thyroid carcinoma. , 2004, Current drug targets. Immune, endocrine and metabolic disorders.
[13] B. Johansson,et al. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer , 2004, Nature Genetics.
[14] T. Hubbard,et al. A census of human cancer genes , 2004, Nature Reviews Cancer.
[15] J. Harbott,et al. Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia. , 2004, Blood.
[16] T. Kroll. Molecular events in follicular thyroid tumors. , 2004, Cancer treatment and research.
[17] T. Barrette,et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. , 2004, Neoplasia.
[18] Toshiyuki Yamada,et al. Molecular biology of the Ets family of transcription factors. , 2003, Gene.
[19] J. Fletcher,et al. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. , 2003, Cancer research.
[20] P. Sorensen,et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. , 2002, Cancer cell.
[21] Pier Paolo Pandolfi,et al. The Role of PML in Tumor Suppression , 2002, Cell.
[22] Y. Nikiforov. RET/PTC rearrangement in thyroid tumors , 2002, Endocrine pathology.
[23] P. Sorensen,et al. The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation. , 2001, Cancer research.
[24] J. Rowley,et al. Chromosome translocations: dangerous liaisons revisited , 2001, Nature Reviews Cancer.
[25] O. Monni,et al. New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays. , 2001, Cancer research.
[26] M. Pierotti. Chromosomal rearrangements in thyroid carcinomas: a recombination or death dilemma. , 2001, Cancer letters.
[27] K. Albertine,et al. Cloning and characterization of the cDNA and gene for human epitheliasin. , 2001, European journal of biochemistry.
[28] C. Sawyers,et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.
[29] C. Sawyers,et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. , 2001, The New England journal of medicine.
[30] R. Hubert,et al. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. , 2001, Cancer research.
[31] F. Mitelman,et al. Recurrent chromosome aberrations in cancer. , 2000, Mutation research.
[32] P. Sorensen,et al. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells , 2000, Oncogene.
[33] L. Hood,et al. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. , 1999, Cancer research.
[34] Johnson M Liu,et al. Chromatin remodeling and leukemia: new therapeutic paradigms. , 1999, Blood.
[35] K. Tanaka,et al. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). , 1999, Blood.
[36] J. Fletcher,et al. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. , 1998, The American journal of pathology.
[37] A. Andrén-sandberg,et al. Cytogenetic analysis of pancreatic carcinomas: Intratumor heterogeneity and nonrandom pattern of chromosome aberrations , 1998, Genes, chromosomes & cancer.
[38] T. Hoshino,et al. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[39] S. Inoue,et al. Role of the histone deacetylase complex in acute promyelocytic leukaemia , 1998, Nature.
[40] S. Minucci,et al. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia , 1998, Nature.
[41] M. Pierotti,et al. Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene , 1998, Oncogene.
[42] P. Sorensen,et al. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma , 1998, Nature Genetics.
[43] H. Rabes,et al. Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. , 1998, Cancer research.
[44] L. Mariani,et al. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.
[45] G. Cimino,et al. ALL1 gene alterations in acute leukemia: biological and clinical aspects. , 1998, Haematologica.
[46] M. Pierotti,et al. Chromosome I rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid‐specific TRK oncogenes , 1997, Genes, chromosomes & cancer.
[47] A. G. Kessel,et al. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[48] M. Pierotti,et al. Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. , 1996, Oncogene.
[49] S Gill,et al. The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. , 1996, Human molecular genetics.
[50] D. Ledbetter,et al. Multicolor Spectral Karyotyping of Human Chromosomes , 1996, Science.
[51] B. Johansson,et al. Primary vs. secondary neoplasia‐associated chromosomal abnormalities—balanced rearrangements vs. genomic imbalances? , 1996, Genes, chromosomes & cancer.
[52] M. Borrello,et al. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma , 1996, Molecular and cellular biology.
[53] D. Ward,et al. Karyotyping human chromosomes by combinatorial multi-fluor FISH , 1996, Nature Genetics.
[54] D Tripathy,et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[55] J. Downing,et al. Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO. , 1996, Current topics in microbiology and immunology.
[56] J. Downing,et al. MLL fusion genes in the 11q23 acute leukemias. , 1996, Cancer treatment and research.
[57] J. Zhang,et al. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. , 1995, Oncogene.
[58] A. Lupas,et al. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain , 1995, Molecular and cellular biology.
[59] T. Rabbitts,et al. Chromosomal translocations in human cancer , 1994, Nature.
[60] J. Rowley,et al. Detection of Fusion Transcripts Generated by the Inversion 16 Chromosome in Acute Myelogenous Leukemia , 1994 .
[61] M. Borrello,et al. A t( 10; 17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma , 1994, Genes, chromosomes & cancer.
[62] M. Santoro,et al. Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. , 1994, Oncogene.
[63] Myriam Alcalay,et al. The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells , 1993, Cell.
[64] A. Sandberg,et al. Translocation (X;1) in papillary renal cell carcinoma. A new cytogenetic subtype. , 1993, Cancer genetics and cytogenetics.
[65] J W Gray,et al. Molecular cytogenetics in human cancer diagnosis , 1992, Cancer.
[66] M. Santoro,et al. Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[67] M. Pierotti,et al. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. , 1992, Oncogene.
[68] P. Freemont,et al. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. , 1991, Science.
[69] O. Witte,et al. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. , 1990, Science.
[70] M. Santoro,et al. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas , 1990, Cell.
[71] G. Daley,et al. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. , 1990, Science.
[72] G. Canellos,et al. Chronic granulocytic leukemia. , 1976, The Medical clinics of North America.
[73] Rowley Jd. Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia. , 1973 .
[74] J. Rowley. A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining , 1973, Nature.
[75] T. Caspersson,et al. Differential binding of alkylating fluorochromes in human chromosomes. , 1970, Experimental cell research.
[76] A M PARFITT,et al. A.T. 10. , 1964, Lancet.
[77] P. Nowell,et al. Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. , 1961, Journal of the National Cancer Institute.
[78] P. Nowell,et al. A minute chromosome in human chronic granulocytic leukemia , 1960 .
[79] P. Jacobs,et al. Chromosome studies in human leukaemia. , 1959, Lancet.